MCF2L-AS1

Summary

MCF2L-AS1 (MCF2L antisense RNA 1, HGNC:39825) is a long non-coding RNA gene on chromosome 13q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39825
Approved symbol	MCF2L-AS1
Name	MCF2L antisense RNA 1
Location	13q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235280
Ensembl biotype	lncRNA
Entrez	100289410
RNAcentral	URS000075B876 — lncRNA, 1173 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000446789

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000446789 — 2 exons

Exon	Start	End
ENSE00001623442	112968619	112968824
ENSE00001705172	112967484	112967989

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 82.02.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0010 / max 31.1688, expressed in 503 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138316	0.9734	500
138315	0.0275	9

Top tissues by expression

273 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	82.02	gold quality
adenohypophysis	UBERON:0002196	80.84	gold quality
pituitary gland	UBERON:0000007	80.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	77.86	gold quality
cortical plate	UBERON:0005343	77.85	gold quality
islet of Langerhans	UBERON:0000006	77.71	gold quality
cerebellar hemisphere	UBERON:0002245	77.32	gold quality
cerebellar cortex	UBERON:0002129	77.20	gold quality
right uterine tube	UBERON:0001302	76.36	gold quality
right lobe of liver	UBERON:0001114	76.08	gold quality
body of pancreas	UBERON:0001150	75.88	gold quality
lower esophagus mucosa	UBERON:0035834	75.17	gold quality
pancreas	UBERON:0001264	75.03	gold quality
cerebellum	UBERON:0002037	74.93	gold quality
apex of heart	UBERON:0002098	73.75	gold quality
rectum	UBERON:0001052	73.67	gold quality
metanephros cortex	UBERON:0010533	72.80	gold quality
ganglionic eminence	UBERON:0004023	72.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.00	gold quality
right frontal lobe	UBERON:0002810	71.62	gold quality
anterior cingulate cortex	UBERON:0009835	71.46	gold quality
body of stomach	UBERON:0001161	71.44	gold quality
minor salivary gland	UBERON:0001830	71.41	gold quality
cingulate cortex	UBERON:0003027	71.38	gold quality
left lobe of thyroid gland	UBERON:0001120	71.11	gold quality
saliva-secreting gland	UBERON:0001044	70.39	gold quality
right lobe of thyroid gland	UBERON:0001119	70.28	gold quality
transverse colon	UBERON:0001157	69.93	gold quality
thyroid gland	UBERON:0002046	69.90	gold quality
prefrontal cortex	UBERON:0000451	69.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.69

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• The lncRNA MCF2L-AS1 controls osteogenic differentiation by regulating miR-33a. (PMID:32255731)
• LncRNA MCF2L-AS1 aggravates proliferation, invasion and glycolysis of colorectal cancer cells via the crosstalk with miR-874-3p/FOXM1 signaling axis. (PMID:32860508)
• Long non-coding RNA MCF2L-AS1 promotes the aggressiveness of colorectal cancer by sponging miR-874-3p and thereby up-regulating CCNE1. (PMID:33037865)
• Long noncoding RNA MCF2L-AS1 promotes the cancer stem cell-like traits in non-small cell lung cancer cells through regulating miR-873-5p level. (PMID:33783940)
• E2F1-induced long non-coding RNA MCF2L-AS1 modulates Cyclin D1 mRNA stability through ELAVL1 to induce Gefitinib resistance in non-small cell lung cancer. (PMID:36257058)
• A high level of the long non-coding RNA MCF2L-AS1 is associated with poor prognosis in breast cancer and MCF2L-AS1 activates YAP transcriptional activity to enhance breast cancer proliferation and metastasis. (PMID:36700469)
• MCF2L-AS1 promotes the biological behaviors of hepatocellular carcinoma cells by regulating the miR-33a-5p/FGF2 axis. (PMID:37432067)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.