MCHR2-AS1

Summary

MCHR2-AS1 (MCHR2 antisense RNA 1, HGNC:48980) is a long non-coding RNA gene on chromosome 6q16.2-q16.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48980
Approved symbol	MCHR2-AS1
Name	MCHR2 antisense RNA 1
Location	6q16.2-q16.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229315
Ensembl biotype	lncRNA
Entrez	728012
RNAcentral	URS000075C87A — lncRNA, 548 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 37 lncRNA

ENST00000430122, ENST00000443234, ENST00000451220, ENST00000452482, ENST00000655249, ENST00000661108, ENST00000663719, ENST00000664329, ENST00000670152, ENST00000735332, ENST00000735333, ENST00000735334, ENST00000735335, ENST00000735336, ENST00000735337, ENST00000735338, ENST00000735339, ENST00000735340, ENST00000735341, ENST00000735342, ENST00000735343, ENST00000735344, ENST00000735345, ENST00000735346, ENST00000735347, ENST00000735348, ENST00000735349, ENST00000735350, ENST00000735351, ENST00000735352, ENST00000735353, ENST00000735354, ENST00000735355, ENST00000735356, ENST00000735357, ENST00000735358, ENST00000735359

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430122 — 3 exons

Exon	Start	End
ENSE00001755318	100000794	100000996
ENSE00004067944	100076242	100076780
ENSE00004067957	99993938	99994204

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 95.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1563 / max 156.0754, expressed in 4 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
68993	0.0982	3
68994	0.0396	3
68992	0.0149	4
68991	0.0036	2

Top tissues by expression

191 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.54	gold quality
right testis	UBERON:0004534	94.31	gold quality
kidney epithelium	UBERON:0004819	93.06	gold quality
testis	UBERON:0000473	92.58	gold quality
islet of Langerhans	UBERON:0000006	90.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.43	gold quality
sperm	CL:0000019	86.28	gold quality
epithelial cell of pancreas	CL:0000083	85.70	gold quality
left ventricle myocardium	UBERON:0006566	85.50	gold quality
adult organism	UBERON:0007023	85.43	gold quality
cardiac muscle of right atrium	UBERON:0003379	85.25	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	82.59	gold quality
myocardium	UBERON:0002349	80.84	gold quality
cerebellar vermis	UBERON:0004720	77.15	gold quality
upper arm skin	UBERON:0004263	77.08	gold quality
vastus lateralis	UBERON:0001379	76.54	gold quality
nasal cavity epithelium	UBERON:0005384	76.35	gold quality
medial globus pallidus	UBERON:0002477	74.76	gold quality
globus pallidus	UBERON:0001875	73.35	gold quality
bone marrow	UBERON:0002371	72.94	gold quality
skeletal muscle tissue	UBERON:0001134	71.85	gold quality
tendon of biceps brachii	UBERON:0008188	71.80	silver quality
vena cava	UBERON:0004087	71.76	silver quality
layer of synovial tissue	UBERON:0007616	70.14	gold quality
pancreatic ductal cell	CL:0002079	70.13	silver quality
deltoid	UBERON:0001476	69.99	gold quality
heart right ventricle	UBERON:0002080	69.54	gold quality
caecum	UBERON:0001153	69.28	gold quality
lateral nuclear group of thalamus	UBERON:0002736	69.14	gold quality
subthalamic nucleus	UBERON:0001906	68.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression. (PMID:26461262)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.