MCM3AP-AS1

Summary

MCM3AP-AS1 (MCM3AP antisense RNA 1, HGNC:16417) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16417
Approved symbol	MCM3AP-AS1
Name	MCM3AP antisense RNA 1
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ10508, NCRNA00031
Ensembl gene	ENSG00000215424
Ensembl biotype	lncRNA
Entrez	114044
RNAcentral	URS000075BD4C — lncRNA, 2338 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000414659, ENST00000420074, ENST00000421927, ENST00000432735, ENST00000444998, ENST00000455567, ENST00000588753, ENST00000590829, ENST00000591223, ENST00000654493, ENST00000656253, ENST00000662666, ENST00000664725, ENST00000669476, ENST00000670190, ENST00000748152, ENST00000748153, ENST00000748154, ENST00000748155, ENST00000748156, ENST00000748157, ENST00000748158

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414659 — 4 exons

Exon	Start	End
ENSE00001312905	46240834	46241019
ENSE00001344241	46229231	46229266
ENSE00001483121	46230327	46230527
ENSE00001667261	46249586	46251701

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 95.16.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.2177 / max 25.0367, expressed in 1005 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189698	2.2177	1005

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.16	gold quality
cortical plate	UBERON:0005343	86.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.88	gold quality
cerebellar hemisphere	UBERON:0002245	82.78	gold quality
cerebellar cortex	UBERON:0002129	82.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.98	gold quality
ventricular zone	UBERON:0003053	81.95	gold quality
ganglionic eminence	UBERON:0004023	81.71	gold quality
cerebellum	UBERON:0002037	81.06	gold quality
sural nerve	UBERON:0015488	80.00	gold quality
apex of heart	UBERON:0002098	78.57	gold quality
right ovary	UBERON:0002118	78.50	gold quality
granulocyte	CL:0000094	77.85	gold quality
left ovary	UBERON:0002119	77.26	gold quality
adrenal tissue	UBERON:0018303	76.89	gold quality
pituitary gland	UBERON:0000007	76.49	gold quality
body of uterus	UBERON:0009853	76.45	gold quality
sperm	CL:0000019	76.43	silver quality
right uterine tube	UBERON:0001302	76.16	gold quality
adenohypophysis	UBERON:0002196	76.12	gold quality
body of pancreas	UBERON:0001150	76.07	gold quality
right adrenal gland	UBERON:0001233	75.95	gold quality
colonic epithelium	UBERON:0000397	75.82	gold quality
mucosa of stomach	UBERON:0001199	75.75	gold quality
ectocervix	UBERON:0012249	75.75	gold quality
transverse colon	UBERON:0001157	75.73	gold quality
metanephros cortex	UBERON:0010533	75.64	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.63	gold quality
ovary	UBERON:0000992	75.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 28)

• MCM3AP antisense RNA 1 (MCM3AP-AS) and miR-17-92 (MIR17HG) acted synergistically to regulate mRNAs in a network module of the long non-coding RNA (lncRNA)-mediated competitive endogenous RNA network (LMCN). (PMID:27229531)
• Circular RNA MCM3AP-AS1 directly bound to miR-194-5p and acted as competing endogenous RNA while subsequently facilitating miR-194-5p target gene FOXA1 expression in hepatocellular carcinoma cells. (PMID:30782188)
• promotes papillary thyroid cancer by regulating the MCM3AP-AS1/miR-211-5p/SPARC axis (PMID:31030335)
• MCM3AP-AS1 regulates EGFR expression.MiR-455 directly targets and regulates LncRNA MCM3AP-AS1 in the hepatocellular carcinoma.MCM3AP-AS1 was significantly upregulated in the hepatocellular carcinoma tissues. (PMID:31237446)
• Investigated the role between MCM3AP antisense RNA 1 (MCM3AP-AS1) and miR-138-5p, and between microRNA 138-5p and forkhead box K1 (FOXK1), in pancreatic cancer. (PMID:31830901)
• up-regulated in osteoarthritis; may regulate miR-142-3p/HMGB1 to promote LPS-induced chondrocyte apoptosis (PMID:31836002)
• LncRNA MCM3AP-AS1 inhibits cell proliferation in cervical squamous cell carcinoma by down-regulating miRNA-93. (PMID:31985002)
• LncRNA MCM3AP-AS1 promotes breast cancer progression via modulating miR-28-5p/CENPF axis. (PMID:32485570)
• Overexpression of long non-coding RNA MCM3AP-AS1 in breast cancer tissues compared to adjacent non-tumour tissues. (PMID:32678686)
• LncRNA MCM3AP-AS1 promotes proliferation, migration and invasion of oral squamous cell carcinoma cells via regulating miR-204-5p/FOXC1. (PMID:32690597)
• lncRNA MCM3AP-AS1 inhibits the progression of colorectal cancer via the miR-19a-3p/FOXF2 axis. (PMID:33450091)
• Identification of HCG18 and MCM3AP-AS1 That Associate With Bone Metastasis, Poor Prognosis and Increased Abundance of M2 Macrophage Infiltration in Prostate Cancer. (PMID:33596783)
• Long noncoding RNA MCM3AP-AS1 enhances cell proliferation and metastasis in colorectal cancer by regulating miR-193a-5p/SENP1. (PMID:33686713)
• Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1beta-induced inflammation via regulating miR-138-5p/SIRT1. (PMID:33942704)
• The MCM3AP-AS1/miR-126/VEGF axis regulates cancer cell invasion and migration in endometrioid carcinoma. (PMID:34256796)
• LncRNA MCM3AP-AS1 sponges miR-148a to enhance cell invasion and migration in small cell lung cancer. (PMID:34271873)
• Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p. (PMID:34346845)
• LncRNA MCM3AP-AS1 Downregulates LncRNA MEG3 in Triple Negative Breast Cancer to Inhibit the Proliferation of Cancer Cells. (PMID:34587438)
• Overexpression of long noncoding RNA MCM3AP-AS1 promotes osteogenic differentiation of dental pulp stem cells via miR-143-3p/IGFBP5 axis. (PMID:34822133)
• MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways. (PMID:35156580)
• SOX4-activated lncRNA MCM3AP-AS1 aggravates osteoarthritis progression by modulating miR-149-5p/Notch1 signaling. (PMID:35202986)
• LncRNA MCM3AP-AS1 Regulates miR-21/PTEN Axis to Affect Cervical Squamous Cell Carcinoma Cell Proliferation and Apoptosis. (PMID:35695665)
• Long Non-Coding RNA MCM3AP-AS1: A Crucial Role in Human Malignancies. (PMID:35783356)
• LncRNA MCM3AP-AS1 serves as a competing endogenous RNA of miR-218 to upregulate GLUT1 in papillary thyroid carcinoma. (PMID:35929906)
• The role of LncRNA MCM3AP-AS1 in human cancer. (PMID:36002764)
• Prognostic Analysis of LncRNA MCM3AP-AS1 in Colorectal Cancer and the Mechanism of Its Effect on Tumor Cell Activity. (PMID:36172487)
• Extracellular vesicles derived from cervical cancer cells carrying MCM3AP-AS1 promote angiogenesis and tumor growth in cervical cancer via the miR-93/p21 axis. (PMID:37137462)
• LncRNA MCM3AP-AS1 is downregulated in atherosclerosis and sponges miR-448 to suppress vascular smooth muscle cell proliferation. (PMID:37266599)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.