MCPH1-AS1

Summary

MCPH1-AS1 (MCPH1 antisense RNA 1, HGNC:51655) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51655
Approved symbol	MCPH1-AS1
Name	MCPH1 antisense RNA 1
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249898
Ensembl biotype	lncRNA
Entrez	100507530
RNAcentral	URS00007E3E96 — lncRNA, 4132 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000515608, ENST00000522897, ENST00000525186, ENST00000527490, ENST00000655775, ENST00000659007, ENST00000659223, ENST00000661193, ENST00000662128, ENST00000662747, ENST00000670222, ENST00000671468, ENST00000692160, ENST00000702576, ENST00000749477, ENST00000749478, ENST00000749479, ENST00000749480, ENST00000749481, ENST00000749482, ENST00000749483, ENST00000749484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000515608 — 5 exons

Exon	Start	End
ENSE00002041672	6648283	6648807
ENSE00002054376	6618475	6619202
ENSE00002073754	6620135	6620224
ENSE00002079509	6620992	6621635
ENSE00002086617	6627151	6627310

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 95.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.1299 / max 108.5483, expressed in 1210 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91706	2.9706	1171
91707	0.1257	48
91704	0.0336	19

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.58	gold quality
oocyte	CL:0000023	94.61	gold quality
secondary oocyte	CL:0000655	94.39	gold quality
oviduct epithelium	UBERON:0004804	83.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.44	gold quality
monocyte	CL:0000576	77.61	gold quality
leukocyte	CL:0000738	76.73	gold quality
cortical plate	UBERON:0005343	75.64	gold quality
ventricular zone	UBERON:0003053	74.67	gold quality
ganglionic eminence	UBERON:0004023	74.65	gold quality
sural nerve	UBERON:0015488	72.53	gold quality
pancreatic ductal cell	CL:0002079	72.32	silver quality
bone marrow cell	CL:0002092	72.24	silver quality
colonic epithelium	UBERON:0000397	71.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.88	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.78	gold quality
amniotic fluid	UBERON:0000173	69.81	gold quality
prefrontal cortex	UBERON:0000451	69.47	gold quality
islet of Langerhans	UBERON:0000006	69.39	gold quality
stromal cell of endometrium	CL:0002255	68.63	gold quality
nucleus accumbens	UBERON:0001882	68.60	gold quality
spinal cord	UBERON:0002240	68.12	gold quality
anterior cingulate cortex	UBERON:0009835	68.06	gold quality
caudate nucleus	UBERON:0001873	67.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.61	gold quality
fallopian tube	UBERON:0003889	67.11	gold quality
right frontal lobe	UBERON:0002810	66.99	gold quality
putamen	UBERON:0001874	66.94	gold quality
hypothalamus	UBERON:0001898	66.22	gold quality
neocortex	UBERON:0001950	66.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.72

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.