MCPH1-DT

Summary

MCPH1-DT (MCPH1 divergent transcript, HGNC:55599) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55599
Approved symbol	MCPH1-DT
Name	MCPH1 divergent transcript
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246089
Ensembl biotype	lncRNA
Entrez	100287015
RNAcentral	URS000075E679 — lncRNA, 2408 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000500118, ENST00000523225, ENST00000606853, ENST00000749255, ENST00000749256, ENST00000749257, ENST00000749258, ENST00000749259, ENST00000749262, ENST00000749263, ENST00000749264, ENST00000749265, ENST00000749266

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500118 — 2 exons

Exon	Start	End
ENSE00004092787	6403551	6405120
ENSE00004092794	6405706	6406580

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 89.62.

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	89.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.90	gold quality
cortical plate	UBERON:0005343	75.16	gold quality
ganglionic eminence	UBERON:0004023	74.76	gold quality
stromal cell of endometrium	CL:0002255	74.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.78	silver quality
adenohypophysis	UBERON:0002196	73.60	gold quality
mucosa of transverse colon	UBERON:0004991	73.54	gold quality
right uterine tube	UBERON:0001302	72.94	gold quality
granulocyte	CL:0000094	72.81	gold quality
ventricular zone	UBERON:0003053	72.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.02	gold quality
mucosa of stomach	UBERON:0001199	71.81	gold quality
pituitary gland	UBERON:0000007	71.67	gold quality
apex of heart	UBERON:0002098	70.94	gold quality
colonic epithelium	UBERON:0000397	70.84	silver quality
lower esophagus mucosa	UBERON:0035834	70.72	gold quality
leukocyte	CL:0000738	70.67	gold quality
monocyte	CL:0000576	70.53	gold quality
right adrenal gland cortex	UBERON:0035827	70.52	gold quality
right coronary artery	UBERON:0001625	70.48	gold quality
gastrocnemius	UBERON:0001388	70.25	gold quality
left adrenal gland cortex	UBERON:0035825	70.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.05	gold quality
right adrenal gland	UBERON:0001233	69.93	gold quality
left adrenal gland	UBERON:0001234	69.90	gold quality
prefrontal cortex	UBERON:0000451	69.72	gold quality
muscle of leg	UBERON:0001383	69.72	gold quality
left coronary artery	UBERON:0001626	69.58	gold quality
anterior cingulate cortex	UBERON:0009835	69.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.25

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.