MCRIP2

Summary

MCRIP2 (MAPK regulated corepressor interacting protein 2, HGNC:14142) is a protein-coding gene on chromosome 16p13.3, encoding MAPK regulated corepressor interacting protein 2 (Q9BUT9).

Located in cytoplasmic stress granule and nucleus.

Source: NCBI Gene 84331 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 6 total
• MANE Select transcript: NM_138418

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14142
Approved symbol	MCRIP2
Name	MAPK regulated corepressor interacting protein 2
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC15416
Ensembl gene	ENSG00000172366
Ensembl biotype	protein_coding
Entrez	84331

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 7 protein_coding, 4 protein_coding_CDS_not_defined, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000307650, ENST00000474840, ENST00000491999, ENST00000575894, ENST00000611328, ENST00000615744, ENST00000619114, ENST00000619377, ENST00000619674, ENST00000620462, ENST00000629534, ENST00000906955, ENST00000914243, ENST00000914244, ENST00000914245, ENST00000914246

RefSeq mRNA: 3 — MANE Select: NM_138418 NM_001331229, NM_001331230, NM_138418

CCDS: CCDS10415

Canonical transcript exons

ENST00000307650 — 5 exons

Exon	Start	End
ENSE00001142260	642120	642249
ENSE00001830427	641828	642043
ENSE00003470891	648120	648474
ENSE00003533098	647783	647884
ENSE00003604381	647417	647544

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 98.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.4686 / max 75.2944, expressed in 1802 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
151956	8.3143	1758
151957	4.7475	1611
151958	0.8671	454
151960	0.3414	135
151959	0.1983	115

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	98.59	gold quality
apex of heart	UBERON:0002098	97.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.49	gold quality
right adrenal gland	UBERON:0001233	96.61	gold quality
right lobe of liver	UBERON:0001114	96.58	gold quality
right adrenal gland cortex	UBERON:0035827	96.37	gold quality
heart left ventricle	UBERON:0002084	96.33	gold quality
cardiac ventricle	UBERON:0002082	96.13	gold quality
ileal mucosa	UBERON:0000331	95.93	gold quality
left adrenal gland cortex	UBERON:0035825	95.83	gold quality
gastrocnemius	UBERON:0001388	95.82	gold quality
left adrenal gland	UBERON:0001234	95.76	gold quality
adrenal cortex	UBERON:0001235	95.72	gold quality
left testis	UBERON:0004533	95.38	gold quality
right testis	UBERON:0004534	95.29	gold quality
right atrium auricular region	UBERON:0006631	95.24	gold quality
metanephros cortex	UBERON:0010533	95.12	gold quality
transverse colon	UBERON:0001157	94.92	gold quality
muscle of leg	UBERON:0001383	94.90	gold quality
adult mammalian kidney	UBERON:0000082	94.72	gold quality
cardiac atrium	UBERON:0002081	94.66	gold quality
cortex of kidney	UBERON:0001225	94.55	gold quality
adrenal gland	UBERON:0002369	94.40	gold quality
tibialis anterior	UBERON:0001385	94.26	gold quality
heart	UBERON:0000948	93.80	gold quality
body of stomach	UBERON:0001161	93.50	gold quality
liver	UBERON:0002107	93.22	gold quality
kidney epithelium	UBERON:0004819	93.06	gold quality
adenohypophysis	UBERON:0002196	92.98	gold quality
skeletal muscle tissue	UBERON:0001134	92.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting MCRIP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-18A-5P	99.29	71.05	806
HSA-MIR-18B-5P	99.29	71.05	806
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4735-3P	99.14	69.85	777
HSA-MIR-92A-1-5P	98.28	64.51	631
HSA-MIR-1302	97.92	67.27	844
HSA-MIR-4298	97.26	66.59	765
HSA-MIR-3194-5P	96.80	64.90	1027

Literature-anchored findings (GeneRIF, showing 1)

• Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling. (PMID:29453251)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mcrip2	ENSDARG00000061256
mus_musculus	Mcrip2	ENSMUSG00000025732
rattus_norvegicus	Mcrip2	ENSRNOG00000020029

Paralogs (2): FGFRL1 (ENSG00000127418), MCRIP1 (ENSG00000225663)

Protein

Protein identifiers

MAPK regulated corepressor interacting protein 2 — Q9BUT9 (reviewed: Q9BUT9)

Alternative names: Protein FAM195A

All UniProt accessions (2): Q9BUT9, I3L172

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Interacts with DDX6. Interacts with MCRIP1.

Subcellular location. Cytoplasm. Stress granule. Nucleus.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the MCRIP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BUT9-1	1	yes
Q9BUT9-2	2

RefSeq proteins (3): NP_001318158, NP_001318159, NP_612427* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029428	MCRIP	Family

Pfam: PF14799

UniProt features (9 total): modified residue 5, chain 1, region of interest 1, compositionally biased region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BUT9-F1	65.56	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 1, 35, 61, 65, 82

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 151 (showing top): GOBP_RESPONSE_TO_COLD, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, MCBRYAN_PUBERTAL_BREAST_4_5WK_DN, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, TTTGCAC_MIR19A_MIR19B, GOBP_TEMPERATURE_HOMEOSTASIS, GOCC_CYTOPLASMIC_STRESS_GRANULE, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP, GOCC_RIBONUCLEOPROTEIN_GRANULE, GOBP_HOMEOSTATIC_PROCESS, GOBP_FATTY_ACID_METABOLIC_PROCESS, NIKOLSKY_BREAST_CANCER_16P13_AMPLICON

GO Biological Process (5): fatty acid metabolic process (GO:0006631), branched-chain amino acid metabolic process (GO:0009081), response to cold (GO:0009409), gene expression (GO:0010467), cold-induced thermogenesis (GO:0106106)

GO Molecular Function (3): RNA binding (GO:0003723), protein-containing complex binding (GO:0044877), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), cytoplasmic stress granule (GO:0010494)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cellular anatomical structure	2
lipid metabolic process	1
monocarboxylic acid metabolic process	1
amino acid metabolic process	1
carboxylic acid metabolic process	1
response to stress	1
response to temperature stimulus	1
macromolecule biosynthetic process	1
adaptive thermogenesis	1
nucleic acid binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
cytoplasmic ribonucleoprotein granule	1

Protein interactions and networks

STRING

448 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MCRIP2	FAM98A	Q8NCA5	442
MCRIP2	ZNF280D	Q6N043	419
MCRIP2	PGCKA1	Q8IY42	419
MCRIP2	COMTD1	Q86VU5	415
MCRIP2	ADGRD1	Q6QNK2	401
MCRIP2	H0YL38	H0YL38	374
MCRIP2	ZNF814	B7Z6K7	370
MCRIP2	MRPS24	P82668	370
MCRIP2	LSM14B	Q9BX40	366
MCRIP2	RTL8C	A6ZKI3	360
MCRIP2	ACBD6	Q9BR61	359
MCRIP2	TATDN1	Q6P1N9	348
MCRIP2	TFPT	P0C1Z6	348
MCRIP2	B4GAT1	O43505	347
MCRIP2	QSER1	Q2KHR3	347

IntAct

32 interactions, top by confidence:

A	B	Type	Score
ATXN2	PABPC1	psi-mi:“MI:0915”(physical association)	0.820
MCRIP2	DDX6	psi-mi:“MI:0403”(colocalization)	0.800
CCNDBP1	JUN	psi-mi:“MI:0914”(association)	0.530
MCRIP2	CASC3	psi-mi:“MI:0914”(association)	0.530
DDX6	MCRIP1	psi-mi:“MI:0914”(association)	0.510
MCRIP1	DDX6	psi-mi:“MI:0914”(association)	0.510
TNFAIP3	LRRIQ3	psi-mi:“MI:0914”(association)	0.420
EIF4ENIF1	PABPC1	psi-mi:“MI:0915”(physical association)	0.400
EIF4ENIF1	MCRIP1	psi-mi:“MI:0915”(physical association)	0.400
ACTA1	PABPC1	psi-mi:“MI:0915”(physical association)	0.400
MPHOSPH8	HCFC1	psi-mi:“MI:0914”(association)	0.350
DDX6	EIF3CL	psi-mi:“MI:0914”(association)	0.350
MCRIP2	RP2	psi-mi:“MI:0914”(association)	0.350
env	TOR1A	psi-mi:“MI:0914”(association)	0.350
PHC3	CBX4	psi-mi:“MI:0914”(association)	0.350
CPEB1	CNOT1	psi-mi:“MI:2364”(proximity)	0.270
SUPV3L1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
DDX6	RPSA2	psi-mi:“MI:2364”(proximity)	0.270
MCRIP2	EEF1G	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (61): FAM195A (Affinity Capture-RNA), FAM195A (Affinity Capture-MS), FAM195A (Affinity Capture-MS), FAM195A (Affinity Capture-MS), FAM195A (Affinity Capture-RNA), FAM195A (Affinity Capture-MS), FAM195A (Affinity Capture-MS), EEF1G (Two-hybrid), FAM195A (Proximity Label-MS), FAM195A (Proximity Label-MS), FAM195A (Proximity Label-MS), FAM195A (Proximity Label-MS), FAM195A (Proximity Label-MS), FAM195A (Proximity Label-MS), FAM195A (Proximity Label-MS)

ESM2 similar proteins: A0A7P0TBJ1, A4IG66, A8E4M4, A8E4X8, A9JSQ8, B0BN72, C9JLW8, O75182, P97578, Q02225, Q0P4B9, Q0P5A7, Q13541, Q1JPG0, Q3MHI4, Q3UGS4, Q3ULM0, Q4QQM5, Q4V8E4, Q504E7, Q5BLE2, Q5DTY9, Q5U465, Q5XJS0, Q5ZIU1, Q5ZKK0, Q60876, Q62141, Q62622, Q63068, Q68DU8, Q6GR21, Q6IEG0, Q6PCG6, Q6TYB5, Q7L4E1, Q7Z3D4, Q8AVJ1, Q8BK03, Q8C6E0

Diamond homologs: A8E4M4, A9JSQ8, B0BN72, C9JLW8, Q0II70, Q0P4B9, Q3UGS4, Q5ZIU1, Q9BUT9, Q9CQB2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

864 predictions. Top by Δscore:

Variant	Effect	Δscore
16:642040:ACAGG:A	donor_loss	1.0000
16:642041:CAGGT:C	donor_loss	1.0000
16:642042:AGG:A	donor_loss	1.0000
16:642043:GGTG:G	donor_loss	1.0000
16:642044:G:T	donor_loss	1.0000
16:646602:GCT:G	donor_gain	1.0000
16:647415:A:AG	acceptor_gain	1.0000
16:647416:G:GA	acceptor_gain	1.0000
16:647416:GT:G	acceptor_gain	1.0000
16:647416:GTC:G	acceptor_gain	1.0000
16:647416:GTCC:G	acceptor_gain	1.0000
16:647416:GTCCA:G	acceptor_gain	1.0000
16:642045:T:A	donor_loss	0.9900
16:646470:A:AG	acceptor_gain	0.9900
16:646471:G:GA	acceptor_gain	0.9900
16:646471:GT:G	acceptor_gain	0.9900
16:646601:GGCT:G	donor_gain	0.9900
16:646602:GCTG:G	donor_gain	0.9900
16:646605:G:GG	donor_gain	0.9900
16:647412:T:A	acceptor_gain	0.9900
16:647542:AAG:A	donor_loss	0.9900
16:647543:AGGT:A	donor_loss	0.9900
16:647544:GGT:G	donor_loss	0.9900
16:647545:G:T	donor_loss	0.9900
16:647546:T:G	donor_loss	0.9900
16:647850:G:GG	donor_gain	0.9900
16:647883:GA:G	donor_gain	0.9900
16:647885:G:GG	donor_gain	0.9900
16:642044:G:GG	donor_gain	0.9800
16:642245:TCGAG:T	donor_loss	0.9800

AlphaMissense

1017 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:647785:T:A	W105R	0.999
16:647785:T:C	W105R	0.999
16:648122:T:C	F139L	0.999
16:648124:T:A	F139L	0.999
16:648124:T:G	F139L	0.999
16:648151:G:C	W148C	0.999
16:648151:G:T	W148C	0.999
16:647436:T:C	F68L	0.998
16:647438:C:A	F68L	0.998
16:647438:C:G	F68L	0.998
16:647527:T:A	V98D	0.998
16:647787:G:C	W105C	0.998
16:647787:G:T	W105C	0.998
16:648138:T:A	L144Q	0.998
16:648138:T:C	L144P	0.998
16:648161:T:C	F152L	0.998
16:648163:C:A	F152L	0.998
16:648163:C:G	F152L	0.998
16:642010:G:A	G7R	0.997
16:642010:G:C	G7R	0.997
16:647532:T:C	F100L	0.997
16:647534:T:A	F100L	0.997
16:647534:T:G	F100L	0.997
16:647536:T:A	V101E	0.997
16:648123:T:C	F139S	0.997
16:648123:T:G	F139C	0.997
16:648132:T:A	I142N	0.997
16:648148:G:C	W147C	0.997
16:648148:G:T	W147C	0.997
16:648162:T:C	F152S	0.997

dbSNP variants (sampled 300 via entrez): RS1000267668 (16:647113 G>A,T), RS1001151526 (16:644028 C>A,G), RS1001596801 (16:641780 G>A,T), RS1001870759 (16:645135 G>A), RS1001995676 (16:642450 C>T), RS1002093006 (16:641992 A>C,G,T), RS1002392553 (16:639913 C>G), RS1002459460 (16:648818 T>C), RS1002730818 (16:646008 C>G), RS1003739170 (16:645201 C>T), RS1003793093 (16:644997 A>C,T), RS1004301131 (16:645590 G>A), RS1004341585 (16:644810 G>A,T), RS1004677541 (16:643926 A>G), RS1004848065 (16:648493 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005951_12	Body mass index	5.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
entinostat	increases expression, affects cotreatment	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Cyclosporine	decreases expression, decreases methylation	2
dicrotophos	decreases expression	1
sodium arsenate	increases abundance, increases expression	1
arsenite	affects binding, increases reaction	1
coumarin	affects phosphorylation	1
perfluorooctane sulfonic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Catechin	decreases expression, affects cotreatment	1
Doxorubicin	increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Lead	affects expression	1
Methyl Methanesulfonate	decreases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SM91	HAP1 FAM195A (-) 1	Cancer cell line	Male
CVCL_SM92	HAP1 FAM195A (-) 2	Cancer cell line	Male
CVCL_SM93	HAP1 FAM195A (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.