MCUR1

Summary

MCUR1 (mitochondrial calcium uniporter regulator 1, HGNC:21097) is a protein-coding gene on chromosome 6p23, encoding Mitochondrial calcium uniporter regulator 1 (Q96AQ8). Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion.

Involved in calcium import into the mitochondrion; calcium ion import; and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane.

Source: NCBI Gene 63933 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 35 total — 1 pathogenic
• Phenotypes (HPO): 1
• MANE Select transcript: NM_001031713

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21097
Approved symbol	MCUR1
Name	mitochondrial calcium uniporter regulator 1
Location	6p23
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20958
Ensembl gene	ENSG00000050393
Ensembl biotype	protein_coding
OMIM	616952
Entrez	63933

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 protein_coding, 1 nonsense_mediated_decay

ENST00000379170, ENST00000488770, ENST00000607303, ENST00000886881, ENST00000886882, ENST00000886883, ENST00000886884, ENST00000886885, ENST00000886886

RefSeq mRNA: 1 — MANE Select: NM_001031713 NM_001031713

CCDS: CCDS35495

Canonical transcript exons

ENST00000379170 — 9 exons

Exon	Start	End
ENSE00003484981	13791878	13791992
ENSE00003580365	13800341	13800382
ENSE00003617901	13793894	13793947
ENSE00003628356	13802243	13802346
ENSE00003661803	13786557	13790864
ENSE00003680024	13801288	13801389
ENSE00003686775	13798833	13798904
ENSE00003701487	13806925	13807044
ENSE00003934180	13814015	13814557

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 97.26.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.7681 / max 217.6384, expressed in 1819 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71854	16.1859	1810
71855	11.5823	1793

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	97.26	gold quality
decidua	UBERON:0002450	96.21	gold quality
amniotic fluid	UBERON:0000173	95.80	gold quality
nephron tubule	UBERON:0001231	95.15	gold quality
mammalian vulva	UBERON:0000997	95.08	gold quality
penis	UBERON:0000989	94.92	gold quality
heart right ventricle	UBERON:0002080	94.85	gold quality
upper arm skin	UBERON:0004263	94.33	gold quality
jejunum	UBERON:0002115	94.03	gold quality
upper leg skin	UBERON:0004262	93.86	gold quality
pigmented layer of retina	UBERON:0001782	93.67	gold quality
body of tongue	UBERON:0011876	93.42	gold quality
kidney epithelium	UBERON:0004819	93.37	gold quality
seminal vesicle	UBERON:0000998	92.76	gold quality
gluteal muscle	UBERON:0002000	92.64	gold quality
diaphragm	UBERON:0001103	92.60	gold quality
duodenum	UBERON:0002114	92.60	gold quality
adult organism	UBERON:0007023	92.49	gold quality
biceps brachii	UBERON:0001507	92.41	gold quality
cranial nerve II	UBERON:0000941	92.38	gold quality
renal medulla	UBERON:0000362	92.31	gold quality
renal glomerulus	UBERON:0000074	92.26	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	92.24	gold quality
tongue	UBERON:0001723	92.16	gold quality
metanephric glomerulus	UBERON:0004736	91.98	gold quality
oral cavity	UBERON:0000167	91.89	gold quality
cortical plate	UBERON:0005343	91.68	gold quality
medial globus pallidus	UBERON:0002477	91.21	gold quality
substantia nigra pars reticulata	UBERON:0001966	91.20	gold quality
superior surface of tongue	UBERON:0007371	91.08	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7316	yes	39.41
E-MTAB-7606	no	972.68
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• CCDC90A is not directly implicated in MCU function, and that the Ca2+ uptake defect associated with loss of CCDC90A function is likely secondary to the respiratory chain deficiency. (PMID:25565209)
• MCUR1 regulates the calcium threshold for the mitochondrial permeability transition. (PMID:26976564)
• Data suggest that MCU regulator (EMRE) might be a structural factor for opening of the mitochondrial calcium uniporter (MCU)-forming pore. (PMID:27001609)
• The survival advantage conferred by MCUR1-mediated mitochondrial Ca(2+) uptake was majorly caused by elevated production of mitochondrial reactive oxygen species and subsequent AKT/MDM2- induced P53 degradation. (PMID:28938844)
• Results found MCUR1 expression significantly higher in HCC with metastasis and associated with tumor progression. The essential role of MCUR1 in promoting epithelial-mesenchymal transition, invasion and migration was found through the activation of ROS/Nrf2/Notch signaling by inducing mitochondrial Ca2+ uptake. (PMID:30909929)
• Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. (PMID:32978391)
• MCUR1 is a prognostic biomarker for ovarian cancer patients. (PMID:34459387)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mcur1	ENSDARG00000016964
mus_musculus	Mcur1	ENSMUSG00000021371
rattus_norvegicus	Mcur1	ENSRNOG00000017988

Paralogs (1): CCDC90B (ENSG00000137500)

Protein

Protein identifiers

Mitochondrial calcium uniporter regulator 1 — Q96AQ8 (reviewed: Q96AQ8)

Alternative names: Coiled-coil domain-containing protein 90A, mitochondrial

All UniProt accessions (3): A0A384NPW7, Q96AQ8, U3KQP8

UniProt curated annotations — full annotation on UniProt →

Function. Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).

Subunit / interactions. Interacts (via coiled coil regions) with MCU; the interaction is direct. Interacts with SMDT1/EMRE; the interaction is direct. Interacts with PPIF.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Ubiquitously expressed.

Similarity. Belongs to the CCDC90 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96AQ8-1	1	yes
Q96AQ8-2	2

RefSeq proteins (1): NP_001026883* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024461	CCDC90-like	Family

Pfam: PF07798

UniProt features (13 total): topological domain 3, sequence variant 2, sequence conflict 2, transmembrane region 2, splice variant 2, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96AQ8-F1	70.82	0.43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 184 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, RNGTGGGC_UNKNOWN, GNF2_MCM5, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_CALCIUM_ION_IMPORT, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN, GOCC_MITOCHONDRIAL_ENVELOPE, PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_UP, TTGGAGA_MIR5155P_MIR519E, GOBP_MONOATOMIC_ION_HOMEOSTASIS, GOBP_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT

GO Biological Process (12): generation of precursor metabolites and energy (GO:0006091), mitochondrial calcium ion transmembrane transport (GO:0006851), cell population proliferation (GO:0008283), cell migration (GO:0016477), calcium import into the mitochondrion (GO:0036444), protein heterooligomerization (GO:0051291), positive regulation of mitochondrial calcium ion concentration (GO:0051561), establishment of localization in cell (GO:0051649), calcium ion import (GO:0070509), monoatomic ion transport (GO:0006811), calcium ion transport (GO:0006816), calcium ion transmembrane transport (GO:0070588)

GO Molecular Function (3): protein-macromolecule adaptor activity (GO:0030674), protein-containing complex binding (GO:0044877), protein binding (GO:0005515)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020), mitochondrial membrane (GO:0031966)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
calcium ion transport	2
binding	2
metabolic process	1
calcium ion transmembrane transport	1
cellular process	1
cell motility	1
mitochondrial calcium ion transmembrane transport	1
intercellular transport	1
protein complex oligomerization	1
mitochondrial calcium ion homeostasis	1
establishment of localization	1
cellular localization	1
transport	1
metal ion transport	1
monoatomic cation transmembrane transport	1
protein binding	1
molecular adaptor activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1

Protein interactions and networks

STRING

714 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MCUR1	MICU2	Q8IYU8	998
MCUR1	MICU1	Q9BPX6	997
MCUR1	MCUB	Q9NWR8	997
MCUR1	SMDT1	Q9H4I9	995
MCUR1	MICU3	Q86XE3	992
MCUR1	SLC25A23	Q9BV35	959
MCUR1	MCU	Q8NE86	910
MCUR1	LETM1	O95202	708
MCUR1	SLC8B1	Q6J4K2	706
MCUR1	SLC25A3	Q00325	515
MCUR1	PPIF	P30405	450
MCUR1	ITPR3	Q14573	447
MCUR1	VDAC1	P21796	442
MCUR1	ITPR1	Q14643	432
MCUR1	UCP2	P55851	408

IntAct

16 interactions, top by confidence:

A	B	Type	Score
FAF2	UBB	psi-mi:“MI:0914”(association)	0.640
MCUR1	CPT2	psi-mi:“MI:0915”(physical association)	0.590
CCDC90B	MCUR1	psi-mi:“MI:0915”(physical association)	0.560
MCUR1	CCDC90B	psi-mi:“MI:0915”(physical association)	0.560
MCUR1	MCU	psi-mi:“MI:0915”(physical association)	0.400
PB2	SEC15L3	psi-mi:“MI:0914”(association)	0.350
CCDC90B	ACTBL2	psi-mi:“MI:0914”(association)	0.350
NTSR1	GPR89A	psi-mi:“MI:0914”(association)	0.350
MCUR1	NCR3LG1	psi-mi:“MI:0914”(association)	0.350
SLC6A7	ABCB1	psi-mi:“MI:0914”(association)	0.350

BioGRID (202): MCUR1 (Affinity Capture-MS), MCUR1 (Affinity Capture-MS), MCUR1 (Affinity Capture-MS), MCUR1 (Affinity Capture-MS), CPT2 (Affinity Capture-MS), MCUR1 (Affinity Capture-MS), AARS2 (Proximity Label-MS), ABCB7 (Proximity Label-MS), ACAD9 (Proximity Label-MS), ACADM (Proximity Label-MS), ACADVL (Proximity Label-MS), ACAT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT2 (Proximity Label-MS), AFG3L2 (Proximity Label-MS)

ESM2 similar proteins: A4Q9F3, A8IHN8, D3YYI7, M0R7T9, O09112, O60347, O88751, P51509, Q09YL6, Q0IHH1, Q13202, Q13505, Q14190, Q147X3, Q17QD9, Q3TZ87, Q3UPL5, Q3V1H9, Q5TGI4, Q5VUJ9, Q5VV17, Q5XI57, Q61079, Q6A039, Q6PDS0, Q6ZVT0, Q7Z7K6, Q80UW0, Q86YJ5, Q8C4U2, Q8CES0, Q8N554, Q8N8J7, Q8TC41, Q8TDR2, Q8WWW0, Q96AQ8, Q96ET8, Q96KN8, Q96MM7

Diamond homologs: Q0P4J6, Q4V897, Q6DJ87, Q8C3X2, Q96AQ8, Q9CXD6, Q9GZT6, Q10073

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	28
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4075385	NM_001031713.4(MCUR1):c.802C>T (p.Arg268Ter)	Pathogenic

SpliceAI

1347 predictions. Top by Δscore:

Variant	Effect	Δscore
6:13791996:T:C	acceptor_gain	1.0000
6:13791996:T:TC	acceptor_gain	1.0000
6:13793946:TA:T	acceptor_gain	1.0000
6:13793948:C:CC	acceptor_gain	1.0000
6:13798826:AACGT:A	donor_loss	1.0000
6:13798827:ACGT:A	donor_loss	1.0000
6:13798828:CGT:C	donor_loss	1.0000
6:13798829:GTA:G	donor_loss	1.0000
6:13798830:TA:T	donor_loss	1.0000
6:13798831:A:AC	donor_gain	1.0000
6:13798831:A:AG	donor_loss	1.0000
6:13798832:C:CC	donor_gain	1.0000
6:13798832:C:CT	donor_loss	1.0000
6:13798832:CCAA:C	donor_gain	1.0000
6:13798903:TC:T	acceptor_gain	1.0000
6:13798904:CC:C	acceptor_gain	1.0000
6:13798904:CCTA:C	acceptor_loss	1.0000
6:13798905:C:CC	acceptor_gain	1.0000
6:13798906:T:C	acceptor_loss	1.0000
6:13798917:C:CT	acceptor_gain	1.0000
6:13798918:A:T	acceptor_gain	1.0000
6:13798922:A:T	acceptor_gain	1.0000
6:13800336:CTTA:C	donor_loss	1.0000
6:13800337:TTAC:T	donor_loss	1.0000
6:13800339:A:AC	donor_gain	1.0000
6:13800339:A:T	donor_loss	1.0000
6:13800340:C:CC	donor_gain	1.0000
6:13800378:ATTTT:A	acceptor_gain	1.0000
6:13800379:TTTT:T	acceptor_gain	1.0000
6:13800380:TTT:T	acceptor_gain	1.0000

AlphaMissense

2302 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:13790831:C:T	G353E	0.998
6:13790850:A:G	C347R	0.998
6:13790864:C:T	G342E	0.997
6:13791880:G:T	A341E	0.997
6:13790832:C:G	G353R	0.996
6:13790832:C:T	G353R	0.996
6:13790852:G:T	T346K	0.996
6:13791878:C:G	G342R	0.996
6:13791878:C:T	G342R	0.996
6:13791911:A:G	S331P	0.996
6:13790843:G:T	T349K	0.995
6:13790846:A:G	L348P	0.995
6:13790858:A:T	I344K	0.995
6:13791886:T:C	Y339C	0.995
6:13791888:T:A	K338N	0.995
6:13791888:T:G	K338N	0.995
6:13791901:A:G	L334P	0.995
6:13791928:A:G	L325P	0.995
6:13791935:C:G	A323P	0.995
6:13790837:G:T	A351D	0.994
6:13790840:A:T	V350E	0.994
6:13791887:A:G	Y339H	0.994
6:13801312:A:C	F239L	0.994
6:13801312:A:T	F239L	0.994
6:13801314:A:G	F239L	0.994
6:13791878:C:A	G342W	0.993
6:13791889:T:A	K338I	0.993
6:13791890:T:C	K338E	0.993
6:13791903:C:A	K333N	0.993
6:13791903:C:G	K333N	0.993

dbSNP variants (sampled 300 via entrez): RS1000078417 (6:13814395 TG>T), RS1000247785 (6:13804696 A>G), RS1000349055 (6:13796408 C>G), RS1000453972 (6:13789981 G>A), RS1000502610 (6:13792556 G>C), RS1000595315 (6:13790234 A>G), RS1000649991 (6:13796172 G>A,C), RS1000663416 (6:13808351 T>C), RS1000736653 (6:13808745 C>T), RS1001070832 (6:13786965 T>C), RS1001160125 (6:13799185 C>T), RS1001183664 (6:13813595 G>A,C), RS1001282302 (6:13807733 C>G,T), RS1001313869 (6:13813936 G>C), RS1001438616 (6:13787163 T>C)

Disease associations

OMIM: gene MIM:616952 | disease phenotypes: MIM:194200

GenCC curated gene-disease

Mondo (3): muscular atrophy (MONDO:0004323), Wolff-Parkinson-White syndrome (MONDO:0008685), skeletal muscle disorder (MONDO:0020120)

Orphanet (2): Skeletal muscle disease (Orphanet:98472), NON RARE IN EUROPE: Wolff-Parkinson-White syndrome (Orphanet:907)

HPO phenotypes

1 total (1 of 1 shown, HPO-id order):

HPO	Term
HP:0001716	Wolff-Parkinson-White syndrome

GWAS associations

0 associations (top):

MeSH disease descriptors (2)

Descriptor	Name	Tree numbers
D009133	Muscular Atrophy	C10.597.613.612; C23.300.070.500; C23.888.592.608.612
D014927	Wolff-Parkinson-White Syndrome	C14.280.067.780.977; C14.280.123.750.977; C16.131.240.400.980

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	3
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation, increases expression	1
sodium arsenite	increases expression, affects cotreatment, increases abundance	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	increases expression	1
ICG 001	decreases expression	1
Zoledronic Acid	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Carbamazepine	affects expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Rotenone	increases expression	1
Tretinoin	decreases expression	1
Valproic Acid	affects expression	1
Isotretinoin	decreases expression	1
Aflatoxin B1	decreases methylation	1
Antirheumatic Agents	increases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XQ34	HAP1 MCUR1 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

145 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT00018356	PHASE4	COMPLETED	Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly
NCT02568020	PHASE4	UNKNOWN	LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD
NCT01373697	PHASE3	UNKNOWN	Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel
NCT01595581	PHASE3	COMPLETED	Testosterone Administration and ACL Reconstruction in Men
NCT03054168	PHASE3	UNKNOWN	Systemic Hormones and Muscle Protein Synthesis
NCT05156320	PHASE3	COMPLETED	Efficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Treated With Nusinersen or Risdiplam
NCT05626855	PHASE3	ACTIVE_NOT_RECRUITING	Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab
NCT00475501	PHASE2	COMPLETED	5-Alpha Reductase and Anabolic Effects of Testosterone
NCT00787098	PHASE2	COMPLETED	Investigating Modes of Progressive Mobility
NCT01369511	PHASE2	COMPLETED	A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
NCT02145949	PHASE2	COMPLETED	Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults
NCT03332238	PHASE2	ACTIVE_NOT_RECRUITING	Stromal Vascular Fraction Cell Therapy to Improve the Repair of Rotator Cuff Tears
NCT03921528	PHASE2	COMPLETED	An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy
NCT04742010	PHASE2	UNKNOWN	Zoledronic Acid for Prevention of Bone Loss After BAriatric Surgery (ZABAS)
NCT05198466	PHASE2	COMPLETED	Electrical Stimulation for Critically Ill Post-Covid-19 Patients
NCT06050668	PHASE2	RECRUITING	Essential Amino Acid Supplementation for Femoral Fragility Fractures
NCT00952887	PHASE1	COMPLETED	A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women
NCT01524406	PHASE1	TERMINATED	Safety Study of HPP593 in Subjects During and After Limb Immobilization
NCT04685213	PHASE1	COMPLETED	Electrical Stimulation for Critically Ill Covid-19 Patients
NCT02773771	PHASE2/PHASE3	WITHDRAWN	Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit
NCT04456530	PHASE2/PHASE3	UNKNOWN	Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
NCT05211986	PHASE1/PHASE2	RECRUITING	Safety and Tolerability of IMM01-STEM in Patients With Muscle Atrophy Related to Knee Osteoarthritis.
NCT03069781	EARLY_PHASE1	WITHDRAWN	The Effects of 17β-estradiol on Skeletal Muscle
NCT03107884	EARLY_PHASE1	ACTIVE_NOT_RECRUITING	Role of Metformin on Muscle Health of Older Adults
NCT07179042	EARLY_PHASE1	ENROLLING_BY_INVITATION	Intertrochanteric Femur Fracture Patients Who Receive Metformin With a Placebo
NCT00006194	Not specified	COMPLETED	Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients
NCT00060970	Not specified	COMPLETED	Evaluating Muscle Function After Ankle Surgery
NCT00447044	Not specified	COMPLETED	Combined Effects of Nutritional and Exercise Countermeasures
NCT00635440	Not specified	COMPLETED	Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients
NCT00835601	Not specified	COMPLETED	Resistive/Cardiovascular Training Study
NCT01080196	Not specified	COMPLETED	Reducing Falls With RENEW in Older Adults Who Have Fallen
NCT01344135	Not specified	COMPLETED	Nutritional Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Muscle Atrophy
NCT01470950	Not specified	UNKNOWN	Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy
NCT01509456	Not specified	COMPLETED	The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation
NCT01788111	Not specified	COMPLETED	Occurrence, Diagnosis and Treatment of Neck and Back Pain in Helicopter Pilots.
NCT01791010	Not specified	COMPLETED	Effects of Inspiratory Muscle Training in Elders
NCT01812460	Not specified	WITHDRAWN	Progressive Resistance Training of the Extensor Muscle of the Thigh in COPD-patients Hospitalized With an Exacerbation
NCT01820702	Not specified	COMPLETED	Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation
NCT01821183	Not specified	COMPLETED	Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players
NCT01872741	Not specified	UNKNOWN	Minipterional Versus Pterional Craniotomy