MDC1-AS1

Summary

MDC1-AS1 (MDC1 antisense RNA 1, HGNC:39764) is a long non-coding RNA gene on chromosome 6p21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39764
Approved symbol	MDC1-AS1
Name	MDC1 antisense RNA 1
Location	6p21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	MDC1-AS
Ensembl gene	ENSG00000224328
Ensembl biotype	lncRNA
Entrez	106478956
RNAcentral	URS0000050C72 — lncRNA, 738 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000442150

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442150 — 3 exons

Exon	Start	End
ENSE00001632548	30712688	30713184
ENSE00001721591	30712312	30712425
ENSE00001773219	30703067	30703193

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 76.99.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	76.99	gold quality
bone marrow cell	CL:0002092	74.19	gold quality
ventricular zone	UBERON:0003053	72.48	gold quality
stromal cell of endometrium	CL:0002255	66.92	gold quality
skeletal muscle tissue	UBERON:0001134	66.75	gold quality
bone marrow	UBERON:0002371	65.66	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.87	gold quality
calcaneal tendon	UBERON:0003701	60.56	gold quality
monocyte	CL:0000576	59.44	gold quality
leukocyte	CL:0000738	59.19	gold quality
placenta	UBERON:0001987	58.47	gold quality
muscle of leg	UBERON:0001383	56.68	gold quality
islet of Langerhans	UBERON:0000006	56.47	gold quality
kidney	UBERON:0002113	55.37	gold quality
adult mammalian kidney	UBERON:0000082	55.11	gold quality
gastrocnemius	UBERON:0001388	54.61	gold quality
liver	UBERON:0002107	54.57	silver quality
blood	UBERON:0000178	53.91	gold quality
urinary bladder	UBERON:0001255	53.87	gold quality
right adrenal gland cortex	UBERON:0035827	53.04	gold quality
tonsil	UBERON:0002372	52.91	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	52.21	gold quality
ectocervix	UBERON:0012249	52.21	gold quality
prefrontal cortex	UBERON:0000451	50.40	gold quality
right lobe of liver	UBERON:0001114	50.19	gold quality
smooth muscle tissue	UBERON:0001135	50.15	gold quality
cortex of kidney	UBERON:0001225	49.95	gold quality
heart left ventricle	UBERON:0002084	48.78	gold quality
uterine cervix	UBERON:0000002	48.63	gold quality
pancreas	UBERON:0001264	48.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MDC1-AS is a novel tumor suppressor through up-regulation of its antisense tumor-suppressing gene MDC1 in glioma. (PMID:27261595)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.