MDS2

Summary

MDS2 (myelodysplastic syndrome 2 translocation associated, HGNC:29633) is a long non-coding RNA gene on chromosome 1p36.

Located in extracellular space.

Source: NCBI Gene 259283 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29633
Approved symbol	MDS2
Name	myelodysplastic syndrome 2 translocation associated
Location	1p36
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000197880
Ensembl biotype	lncRNA
OMIM	607305
Entrez	259283
RNAcentral	URS0000D64BA3 — lncRNA, 1029 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000374555, ENST00000477916, ENST00000686180, ENST00000686679, ENST00000795854, ENST00000795855, ENST00000795856

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000374555 — 7 exons

Exon	Start	End
ENSE00001271337	23639109	23639251
ENSE00001463815	23627781	23627998
ENSE00001463817	23627334	23627537
ENSE00001801608	23628507	23628597
ENSE00003518371	23640389	23640568
ENSE00003524312	23639680	23639795
ENSE00003820340	23629481	23629557

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 74.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3726 / max 71.7291, expressed in 72 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1351	0.2558	63
1350	0.1168	46

Top tissues by expression

216 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.34	silver quality
sural nerve	UBERON:0015488	68.67	silver quality
lymph node	UBERON:0000029	68.23	gold quality
blood	UBERON:0000178	66.37	gold quality
granulocyte	CL:0000094	66.35	gold quality
bone marrow cell	CL:0002092	64.01	silver quality
epithelium of nasopharynx	UBERON:0001951	63.11	gold quality
cortical plate	UBERON:0005343	62.73	silver quality
vermiform appendix	UBERON:0001154	62.41	gold quality
leukocyte	CL:0000738	61.61	gold quality
caecum	UBERON:0001153	61.08	gold quality
left lobe of thyroid gland	UBERON:0001120	60.95	gold quality
tonsil	UBERON:0002372	60.56	gold quality
thyroid gland	UBERON:0002046	60.46	gold quality
right lobe of thyroid gland	UBERON:0001119	60.33	gold quality
spleen	UBERON:0002106	60.08	gold quality
ventricular zone	UBERON:0003053	59.65	gold quality
ganglionic eminence	UBERON:0004023	58.98	silver quality
small intestine Peyer’s patch	UBERON:0003454	56.58	gold quality
bone marrow	UBERON:0002371	56.57	silver quality
mucosa of transverse colon	UBERON:0004991	56.18	gold quality
vena cava	UBERON:0004087	55.42	gold quality
superficial temporal artery	UBERON:0001614	55.28	gold quality
small intestine	UBERON:0002108	54.85	gold quality
stromal cell of endometrium	CL:0002255	54.50	gold quality
nasal cavity mucosa	UBERON:0001826	54.29	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.06	silver quality
tendon	UBERON:0000043	54.04	gold quality
skin of hip	UBERON:0001554	53.94	silver quality
gingival epithelium	UBERON:0001949	53.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The product of the ETV6-MDS2 fusion transcript in a patient with myelodysplastic syndrome predicts a short ETV6 protein containing the first 54 amino acids of ETV6 plus four novel amino acids, lacking both the PTN and the DNA-binding domains. (PMID:12203785)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.