MECOM-AS1

Summary

MECOM-AS1 (MECOM antisense RNA 1, HGNC:40368) is a long non-coding RNA gene on chromosome 3q26.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40368
Approved symbol	MECOM-AS1
Name	MECOM antisense RNA 1
Location	3q26.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000241479
Ensembl biotype	lncRNA
Entrez	105374205
RNAcentral	URS00004CCCB9 — lncRNA, 535 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000480669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000480669 — 5 exons

Exon	Start	End
ENSE00001818790	169463944	169464122
ENSE00001920261	169467034	169467100
ENSE00001923568	169476886	169477052
ENSE00001934443	169470145	169470197
ENSE00001955496	169447867	169447935

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 83.60.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	83.60	gold quality
esophagus mucosa	UBERON:0002469	74.79	gold quality
calcaneal tendon	UBERON:0003701	66.01	gold quality
esophagus	UBERON:0001043	64.94	gold quality
fundus of stomach	UBERON:0001160	63.31	gold quality
body of pancreas	UBERON:0001150	63.01	gold quality
stomach	UBERON:0000945	61.83	gold quality
pancreas	UBERON:0001264	61.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.56	gold quality
vagina	UBERON:0000996	61.27	gold quality
body of stomach	UBERON:0001161	60.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.24	gold quality
skeletal muscle tissue	UBERON:0001134	59.80	gold quality
tonsil	UBERON:0002372	59.16	gold quality
kidney	UBERON:0002113	57.72	gold quality
gall bladder	UBERON:0002110	57.09	gold quality
islet of Langerhans	UBERON:0000006	56.70	gold quality
ectocervix	UBERON:0012249	55.92	gold quality
adult mammalian kidney	UBERON:0000082	55.58	gold quality
urinary bladder	UBERON:0001255	55.40	gold quality
right lung	UBERON:0002167	55.38	gold quality
endometrium	UBERON:0001295	55.26	gold quality
mucosa of stomach	UBERON:0001199	55.13	gold quality
ascending aorta	UBERON:0001496	54.75	gold quality
thoracic aorta	UBERON:0001515	54.50	gold quality
duodenum	UBERON:0002114	54.36	gold quality
lung	UBERON:0002048	53.16	gold quality
muscle of leg	UBERON:0001383	52.82	gold quality
vermiform appendix	UBERON:0001154	52.59	gold quality
subcutaneous adipose tissue	UBERON:0002190	52.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.68

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.