MED10

Summary

MED10 (mediator complex subunit 10, HGNC:28760) is a protein-coding gene on chromosome 5p15.31, encoding Mediator of RNA polymerase II transcription subunit 10 (Q9BTT4). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. It is a selective cancer dependency (DepMap: 46.4% of cell lines).

MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).

Source: NCBI Gene 84246 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 26 total
• Cancer dependency (DepMap): dependent in 46.4% of screened cell lines
• MANE Select transcript: NM_032286

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28760
Approved symbol	MED10
Name	mediator complex subunit 10
Location	5p15.31
Locus type	gene with protein product
Status	Approved
Aliases	TRG20, L6, MGC5309, NUT2
Ensembl gene	ENSG00000133398
Ensembl biotype	protein_coding
OMIM	612382
Entrez	84246

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 2 protein_coding, 2 retained_intron

ENST00000255764, ENST00000503112, ENST00000504058, ENST00000924358

RefSeq mRNA: 1 — MANE Select: NM_032286 NM_032286

CCDS: CCDS34134

Canonical transcript exons

ENST00000255764 — 4 exons

Exon	Start	End
ENSE00000909238	6374324	6374426
ENSE00001166330	6377166	6377249
ENSE00001223115	6371874	6372601
ENSE00002051051	6378362	6378547

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 94.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.0005 / max 132.9588, expressed in 1817 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60855	23.0505	1817
60854	0.6216	301
60856	0.3284	155

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	94.61	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.59	gold quality
leukocyte	CL:0000738	94.38	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.23	gold quality
prefrontal cortex	UBERON:0000451	94.18	gold quality
tibial artery	UBERON:0007610	94.08	gold quality
popliteal artery	UBERON:0002250	94.07	gold quality
oocyte	CL:0000023	94.06	gold quality
anterior cingulate cortex	UBERON:0009835	93.70	gold quality
aorta	UBERON:0000947	93.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	93.53	gold quality
lower esophagus	UBERON:0013473	93.51	gold quality
thoracic aorta	UBERON:0001515	93.35	gold quality
ascending aorta	UBERON:0001496	93.34	gold quality
descending thoracic aorta	UBERON:0002345	93.32	gold quality
hypothalamus	UBERON:0001898	93.29	gold quality
left coronary artery	UBERON:0001626	93.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.21	gold quality
tibial nerve	UBERON:0001323	93.00	gold quality
right frontal lobe	UBERON:0002810	93.00	gold quality
lymph node	UBERON:0000029	92.98	gold quality
skin of abdomen	UBERON:0001416	92.91	gold quality
right coronary artery	UBERON:0001625	92.89	gold quality
body of uterus	UBERON:0009853	92.83	gold quality
omental fat pad	UBERON:0010414	92.67	gold quality
peritoneum	UBERON:0002358	92.65	gold quality
spinal cord	UBERON:0002240	92.58	gold quality
coronary artery	UBERON:0001621	92.48	gold quality
secondary oocyte	CL:0000655	92.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

29 targeting MED10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-567	99.63	68.57	1219
HSA-MIR-543	99.52	69.03	2595
HSA-MIR-449B-3P	99.20	67.24	1047
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-491-3P	98.88	68.86	1224
HSA-MIR-935	98.82	69.36	1072
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-1-5P	98.70	68.66	1017
HSA-MIR-423-5P	98.69	67.48	1522
HSA-MIR-3184-5P	98.56	67.13	1491
HSA-MIR-4773	98.35	67.30	1710
HSA-MIR-6831-5P	98.26	67.20	990
HSA-MIR-1255B-2-3P	97.80	67.04	880
HSA-MIR-3927-3P	97.68	66.76	892
HSA-MIR-5194	96.77	63.91	1021
HSA-MIR-5591-3P	96.23	67.03	489
HSA-MIR-1914-3P	95.07	63.37	762
HSA-MIR-7975	95.04	66.76	516
HSA-MIR-4746-5P	94.32	69.49	70

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 46.4% of screened cell lines.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	med10	ENSDARG00000070623
mus_musculus	Med10	ENSMUSG00000021598
rattus_norvegicus	Med10	ENSRNOG00000017150

Protein

Protein identifiers

Mediator of RNA polymerase II transcription subunit 10 — Q9BTT4 (reviewed: Q9BTT4)

Alternative names: Mediator complex subunit 10, Transformation-related gene 17 protein, Transformation-related gene 20 protein

All UniProt accessions (1): Q9BTT4

UniProt curated annotations — full annotation on UniProt →

Function. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subunit / interactions. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Subcellular location. Nucleus.

Similarity. Belongs to the Mediator complex subunit 10 family.

RefSeq proteins (1): NP_115662* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019145	Mediator_Med10	Family

Pfam: PF09748

UniProt features (6 total): helix 5, chain 1

Structure

Experimental structures (PDB)

11 structures.

PDB	Method	Resolution (Å)
7EMF	ELECTRON MICROSCOPY	3.5
8TRH	ELECTRON MICROSCOPY	3.7
7ENA	ELECTRON MICROSCOPY	4.07
7ENC	ELECTRON MICROSCOPY	4.13
8GXS	ELECTRON MICROSCOPY	4.16
7ENJ	ELECTRON MICROSCOPY	4.4
7NVR	ELECTRON MICROSCOPY	4.5
8T9D	ELECTRON MICROSCOPY	4.66
7LBM	ELECTRON MICROSCOPY	4.8
8GXQ	ELECTRON MICROSCOPY	5.04
8TQW	ELECTRON MICROSCOPY	8.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BTT4-F1	92.87	0.87

Function

Pathways and Gene Ontology

Reactome pathways

20 pathways

ID	Pathway
R-HSA-1989781	PPARA activates gene expression
R-HSA-212436	Generic Transcription Pathway
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
R-HSA-9833110	RSV-host interactions
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
R-HSA-1266738	Developmental Biology
R-HSA-1430728	Metabolism
R-HSA-1643685	Disease
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-400206	Regulation of lipid metabolism by PPARalpha
R-HSA-556833	Metabolism of lipids
R-HSA-5663205	Infectious disease
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway
R-HSA-9824446	Viral Infection Pathways
R-HSA-9843745	Adipogenesis
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes

MSigDB gene sets: 135 (showing top): REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, WEI_MYCN_TARGETS_WITH_E_BOX, WANG_LMO4_TARGETS_DN, GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_MAINTENANCE_OF_CELL_NUMBER, GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_II_PROMOTER, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS, GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION, GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION, GOCC_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATOR_COMPLEX, GOCC_TRANSFERASE_COMPLEX

GO Biological Process (7): protein ubiquitination (GO:0016567), positive regulation of transcription elongation by RNA polymerase II (GO:0032968), somatic stem cell population maintenance (GO:0035019), RNA polymerase II preinitiation complex assembly (GO:0051123), positive regulation of transcription initiation by RNA polymerase II (GO:0060261), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (3): transcription coregulator activity (GO:0003712), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515)

GO Cellular Component (5): ubiquitin ligase complex (GO:0000151), nucleus (GO:0005634), nucleoplasm (GO:0005654), mediator complex (GO:0016592), core mediator complex (GO:0070847)

Reactome top-level categories

Rollup of top-15 pathways:

Category	Pathways
Gene expression (Transcription)	2
Regulation of lipid metabolism by PPARalpha	1
RNA Polymerase II Transcription	1
Adipogenesis	1
Respiratory Syncytial Virus Infection Pathway	1
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	1
Metabolism of lipids	1
Metabolism	1
Disease	1
Epigenetic regulation by WDR5-containing histone modifying complexes	1
Viral Infection Pathways	1
Infectious disease	1
Developmental Biology	1
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	1
Epigenetic regulation of gene expression	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of transcription by RNA polymerase II	2
transcription initiation at RNA polymerase II promoter	2
transcription by RNA polymerase II	2
protein modification by small protein conjugation	1
transcription elongation by RNA polymerase II	1
positive regulation of DNA-templated transcription, elongation	1
regulation of transcription elongation by RNA polymerase II	1
stem cell population maintenance	1
transcription preinitiation complex assembly	1
regulation of transcription initiation by RNA polymerase II	1
positive regulation of DNA-templated transcription initiation	1
regulation of DNA-templated transcription	1
regulation of transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
transcription regulator activity	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
core mediator complex	1
nuclear protein-containing complex	1
RNA polymerase II transcription regulator complex	1

Protein interactions and networks

STRING

1412 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MED10	MED7	O43513	996
MED10	MED19	A0JLT2	987
MED10	MED31	Q9Y3C7	977
MED10	MED9	Q9NWA0	977
MED10	MED17	Q9NVC6	976
MED10	MED11	Q9P086	974
MED10	MED14	O60244	972
MED10	MED22	Q15528	971
MED10	MED6	O75586	964
MED10	MED18	Q9BUE0	959
MED10	MED21	Q13503	957
MED10	MED8	Q96G25	949
MED10	MED15	Q96RN5	911
MED10	MED30	Q96HR3	908
MED10	MED20	Q9H944	904

IntAct

133 interactions, top by confidence:

A	B	Type	Score
MED10	MED7	psi-mi:“MI:0915”(physical association)	0.920
MED10	MED19	psi-mi:“MI:0914”(association)	0.910
MED10	MED19	psi-mi:“MI:0915”(physical association)	0.910
MED10	MED8	psi-mi:“MI:0914”(association)	0.910
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
MED4	MED19	psi-mi:“MI:0914”(association)	0.900
MED29	MED19	psi-mi:“MI:0914”(association)	0.890
MED21	MED19	psi-mi:“MI:0914”(association)	0.880
MED10	MED24	psi-mi:“MI:0914”(association)	0.870
MED10	MED6	psi-mi:“MI:0914”(association)	0.870
CDK8	MED19	psi-mi:“MI:2364”(proximity)	0.850
CDK8	MED19	psi-mi:“MI:0914”(association)	0.850
MED20	MED19	psi-mi:“MI:0914”(association)	0.840
MED18	MED19	psi-mi:“MI:0914”(association)	0.840

BioGRID (374): MED10 (Affinity Capture-MS), MED10 (Affinity Capture-MS), MED10 (Affinity Capture-MS), MED10 (Affinity Capture-MS), MED10 (Affinity Capture-MS), MED10 (Affinity Capture-MS), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation), MED10 (Co-fractionation)

ESM2 similar proteins: A1ZBT5, O42958, P0C5E6, P38304, Q06213, Q08BU1, Q0U8U9, Q0VIA1, Q16RR7, Q16TJ7, Q177A7, Q17NH9, Q17P98, Q23679, Q294G7, Q3ZCF2, Q4R6W4, Q53HL2, Q54XB0, Q561X3, Q5HZZ6, Q5ISW3, Q5ISW5, Q5M8Y7, Q5R6P5, Q5RBS5, Q5XG48, Q61BU1, Q626S1, Q6CM22, Q6CVN3, Q6DD30, Q6DJ25, Q6FQ75, Q6NYT1, Q758L3, Q758M1, Q7KBL8, Q7PTL0, Q7Q6D6

Diamond homologs: A1CR70, A1D434, A3LPQ8, F4HPA7, P87310, Q0CTF3, Q0U8U9, Q0VIA1, Q16G71, Q1E0Q7, Q2H8S0, Q3ZCF2, Q4R6W4, Q4WJH6, Q5A3K2, Q5B5I6, Q5R6P5, Q6BWK1, Q6C5P0, Q6CVN3, Q6DJ25, Q6IP67, Q7Q5R5, Q7RXK7, Q9BTT4, Q9CXU0, Q9GYU7, Q54GE5, P45966, Q61Z20, Q758M1, Q9FHZ2, Q4PDA7, Q6FQ75, Q06213

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MED10	“form complex”	“Core mediator complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 63 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Respiratory Syncytial Virus Infection Pathway	27	110.8×	6e-50
RSV-host interactions	27	88.0×	6e-47
Adipogenesis	27	88.0×	6e-47
Regulation of lipid metabolism by PPARalpha	27	79.3×	1e-45
Transcriptional regulation of white adipocyte differentiation	27	73.0×	2e-44
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	16	71.8×	3e-25
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	16	65.6×	1e-24
Epigenetic regulation by WDR5-containing histone modifying complexes	17	54.7×	9e-25

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of transcription elongation by RNA polymerase II	23	125.8×	1e-42
positive regulation of transcription initiation by RNA polymerase II	25	123.5×	4e-46
RNA polymerase II preinitiation complex assembly	23	113.7×	1e-41
transcription initiation at RNA polymerase II promoter	7	47.7×	6e-09
somatic stem cell population maintenance	10	45.1×	9e-13
transcription by RNA polymerase II	7	9.0×	3e-04
protein ubiquitination	11	8.3×	3e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

26 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	17
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

761 predictions. Top by Δscore:

Variant	Effect	Δscore
5:6374318:TCTTA:T	donor_loss	1.0000
5:6374319:CTTAC:C	donor_loss	1.0000
5:6374320:TTA:T	donor_loss	1.0000
5:6374321:TAC:T	donor_loss	1.0000
5:6374322:ACCT:A	donor_loss	1.0000
5:6374422:TATAT:T	acceptor_gain	1.0000
5:6374423:ATAT:A	acceptor_gain	1.0000
5:6374424:TAT:T	acceptor_gain	1.0000
5:6374425:AT:A	acceptor_gain	1.0000
5:6374427:C:CC	acceptor_gain	1.0000
5:6377164:A:AC	donor_gain	1.0000
5:6377165:C:CA	donor_gain	1.0000
5:6377165:CT:C	donor_gain	1.0000
5:6378357:CTCA:C	donor_loss	1.0000
5:6378358:TCACA:T	donor_loss	1.0000
5:6378359:CAC:C	donor_loss	1.0000
5:6378360:A:AC	donor_gain	1.0000
5:6378360:ACAG:A	donor_gain	1.0000
5:6378361:C:CA	donor_gain	1.0000
5:6378361:CA:C	donor_gain	1.0000
5:6378361:CAG:C	donor_gain	1.0000
5:6378361:CAGC:C	donor_gain	1.0000
5:6378361:CAGCT:C	donor_gain	1.0000
5:6372599:TTT:T	acceptor_gain	0.9900
5:6372602:C:CC	acceptor_gain	0.9900
5:6374317:GTCTT:G	donor_loss	0.9900
5:6374322:A:AC	donor_gain	0.9900
5:6374323:C:CC	donor_gain	0.9900
5:6377157:GTTAC:G	donor_loss	0.9900
5:6377158:TTAC:T	donor_loss	0.9900

AlphaMissense

906 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:6374403:G:T	P77H	1.000
5:6374404:G:A	P77S	1.000
5:6378449:A:G	L12P	1.000
5:6372573:A:G	L113P	0.999
5:6374343:C:T	G97D	0.999
5:6374344:C:G	G97R	0.999
5:6374357:A:C	N92K	0.999
5:6374357:A:T	N92K	0.999
5:6374370:G:T	A88D	0.999
5:6374371:C:G	A88P	0.999
5:6374379:A:G	L85P	0.999
5:6374387:T:A	K82N	0.999
5:6374387:T:G	K82N	0.999
5:6374395:A:C	Y80D	0.999
5:6374403:G:C	P77R	0.999
5:6374404:G:T	P77T	0.999
5:6374405:A:C	N76K	0.999
5:6374405:A:T	N76K	0.999
5:6374418:T:A	D72V	0.999
5:6374421:A:T	I71K	0.999
5:6377172:A:T	V67D	0.999
5:6377181:G:C	P64R	0.999
5:6377181:G:T	P64Q	0.999
5:6377182:G:T	P64T	0.999
5:6377184:A:T	V63E	0.999
5:6378362:A:G	L41P	0.999
5:6378374:A:G	L37P	0.999
5:6378397:G:C	F29L	0.999
5:6378397:G:T	F29L	0.999
5:6378399:A:G	F29L	0.999

dbSNP variants (sampled 300 via entrez): RS1000038424 (5:6379736 A>C), RS1000560919 (5:6378458 T>C), RS1001226019 (5:6378263 G>A,T), RS1001276581 (5:6378027 G>A), RS1002225424 (5:6375024 G>A), RS1002485189 (5:6378058 G>A,T), RS1002694203 (5:6372299 C>A,G), RS1002789390 (5:6371756 G>A,C), RS1003046721 (5:6372134 A>G), RS1003437781 (5:6376523 T>C), RS1003565968 (5:6376986 T>G), RS1003618014 (5:6376746 C>A,T), RS1003919727 (5:6371530 A>G), RS1004064045 (5:6373626 G>A), RS1004112841 (5:6373510 G>A,C)

Disease associations

OMIM: gene MIM:612382 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects expression	3
Carbamazepine	affects expression	2
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
Cadmium Chloride	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
lead acetate	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
methylparaben	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
nickel sulfate	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
K 7174	increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, decreases expression	1
Diclofenac	affects expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Lead	affects splicing	1
Methyl Methanesulfonate	increases expression	1
Phenobarbital	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.