MED22

Summary

MED22 (mediator complex subunit 22, HGNC:11477) is a protein-coding gene on chromosome 9q34.2, encoding Mediator of RNA polymerase II transcription subunit 22 (Q15528). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. It is a common-essential gene (DepMap: required in 98.9% of cancer cell lines).

This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed.

Source: NCBI Gene 6837 — RefSeq curated summary.

At a glance

• Gene–disease (curated): complex neurodevelopmental disorder (Moderate, GenCC)
• GWAS associations: 29
• Clinical variants (ClinVar): 195 total — 2 likely-pathogenic
• Cancer dependency (DepMap): dependent in 98.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_133640

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11477
Approved symbol	MED22
Name	mediator complex subunit 22
Location	9q34.2
Locus type	gene with protein product
Status	Approved
Aliases	Med24, SRB6
Ensembl gene	ENSG00000148297
Ensembl biotype	protein_coding
OMIM	185641
Entrez	6837

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 12 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000343730, ENST00000371999, ENST00000446777, ENST00000457204, ENST00000471524, ENST00000482295, ENST00000494177, ENST00000610672, ENST00000610888, ENST00000614493, ENST00000904047, ENST00000925577, ENST00000925578, ENST00000925579

RefSeq mRNA: 2 — MANE Select: NM_133640 NM_133640, NM_181491

CCDS: CCDS6963, CCDS6964

Canonical transcript exons

ENST00000343730 — 5 exons

Exon	Start	End
ENSE00001136284	133346540	133346700
ENSE00001386820	133338312	133341694
ENSE00003561732	133345172	133345252
ENSE00003786854	133344125	133344333
ENSE00003890317	133347922	133348131

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 88.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.3767 / max 73.3363, expressed in 1793 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102983	11.2020	1790
102982	0.1747	61

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	88.35	gold quality
granulocyte	CL:0000094	87.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	87.43	gold quality
lower esophagus	UBERON:0013473	87.42	gold quality
blood	UBERON:0000178	87.16	gold quality
sural nerve	UBERON:0015488	86.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	86.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	86.51	gold quality
right coronary artery	UBERON:0001625	86.49	gold quality
body of uterus	UBERON:0009853	86.37	gold quality
mucosa of stomach	UBERON:0001199	86.29	gold quality
prefrontal cortex	UBERON:0000451	86.26	gold quality
apex of heart	UBERON:0002098	85.88	gold quality
left uterine tube	UBERON:0001303	85.78	gold quality
stromal cell of endometrium	CL:0002255	85.64	gold quality
endocervix	UBERON:0000458	85.58	gold quality
myometrium	UBERON:0001296	85.51	gold quality
monocyte	CL:0000576	85.48	gold quality
ganglionic eminence	UBERON:0004023	85.39	gold quality
leukocyte	CL:0000738	85.38	gold quality
popliteal artery	UBERON:0002250	85.34	gold quality
tibial artery	UBERON:0007610	85.34	gold quality
frontal cortex	UBERON:0001870	85.11	gold quality
right ovary	UBERON:0002118	84.95	gold quality
ventricular zone	UBERON:0003053	84.71	gold quality
heart left ventricle	UBERON:0002084	84.70	gold quality
left adrenal gland cortex	UBERON:0035825	84.65	gold quality
thoracic aorta	UBERON:0001515	84.63	gold quality
ascending aorta	UBERON:0001496	84.57	gold quality
esophagus	UBERON:0001043	84.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.88

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT5A, STAT5B

miRNA regulators (miRDB)

5 targeting MED22, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-6814-5P	99.03	66.68	1273
HSA-MIR-6793-3P	97.66	65.78	1084
HSA-MIR-664B-5P	96.74	67.50	509

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 4)

• Hu-Surf5 encodes three different transcripts, Surf-5a, Surf-5b, and Surf-5c, which result from alternative splicing. (PMID:11891058)
• functional communications between the MED1 subunit and the MED24-containing submodule that mediate estrogen receptor functions and growth of both normal mammary epithelial cells and breast carcinoma cells. (PMID:22331469)
• Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death. (PMID:33208756)
• This publication also contains human sequence. (PMID:8586415)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	med22	ENSDARG00000014148
mus_musculus	Med22	ENSMUSG00000015776
rattus_norvegicus	Med22	ENSRNOG00000005059
drosophila_melanogaster	MED22	FBGN0040339
drosophila_melanogaster	CG32971	FBGN0052971
caenorhabditis_elegans		WBGENE00007022

Protein

Protein identifiers

Mediator of RNA polymerase II transcription subunit 22 — Q15528 (reviewed: Q15528)

Alternative names: Mediator complex subunit 22, Surfeit locus protein 5

All UniProt accessions (5): Q15528, E7EN96, E9PGW7, Q5T8T7, Q5T8T8

UniProt curated annotations — full annotation on UniProt →

Function. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subunit / interactions. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Subcellular location. Nucleus.

Similarity. Belongs to the Mediator complex subunit 22 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q15528-1	Surf5B	yes
Q15528-2	Surf5A

RefSeq proteins (2): NP_598395, NP_852468 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009332	Med22	Family

Pfam: PF06179

UniProt features (8 total): helix 3, chain 1, region of interest 1, coiled-coil region 1, splice variant 1, strand 1

Structure

Experimental structures (PDB)

11 structures.

PDB	Method	Resolution (Å)
7EMF	ELECTRON MICROSCOPY	3.5
8TRH	ELECTRON MICROSCOPY	3.7
7ENA	ELECTRON MICROSCOPY	4.07
7ENC	ELECTRON MICROSCOPY	4.13
8GXS	ELECTRON MICROSCOPY	4.16
7ENJ	ELECTRON MICROSCOPY	4.4
7NVR	ELECTRON MICROSCOPY	4.5
8T9D	ELECTRON MICROSCOPY	4.66
7LBM	ELECTRON MICROSCOPY	4.8
8GXQ	ELECTRON MICROSCOPY	5.04
8TQW	ELECTRON MICROSCOPY	8.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15528-F1	79.78	0.52

Function

Pathways and Gene Ontology

Reactome pathways

12 pathways

ID	Pathway
R-HSA-1989781	PPARA activates gene expression
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
R-HSA-9833110	RSV-host interactions
R-HSA-1266738	Developmental Biology
R-HSA-1430728	Metabolism
R-HSA-1643685	Disease
R-HSA-400206	Regulation of lipid metabolism by PPARalpha
R-HSA-556833	Metabolism of lipids
R-HSA-5663205	Infectious disease
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway
R-HSA-9824446	Viral Infection Pathways
R-HSA-9843745	Adipogenesis

MSigDB gene sets: 299 (showing top): REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN, AACYNNNNTTCCS_UNKNOWN, CHX10_01, PUJANA_CHEK2_PCC_NETWORK, BROWNE_HCMV_INFECTION_24HR_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, OCT1_03, GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6, GOBP_MAINTENANCE_OF_CELL_NUMBER, GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION

GO Biological Process (4): positive regulation of transcription elongation by RNA polymerase II (GO:0032968), RNA polymerase II preinitiation complex assembly (GO:0051123), positive regulation of transcription initiation by RNA polymerase II (GO:0060261), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (2): transcription coregulator activity (GO:0003712), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), mediator complex (GO:0016592), core mediator complex (GO:0070847)

Reactome top-level categories

Rollup of top-9 pathways:

Category	Pathways
Regulation of lipid metabolism by PPARalpha	1
Adipogenesis	1
Respiratory Syncytial Virus Infection Pathway	1
Metabolism of lipids	1
Metabolism	1
Disease	1
Viral Infection Pathways	1
Infectious disease	1
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of transcription by RNA polymerase II	2
transcription initiation at RNA polymerase II promoter	2
cellular anatomical structure	2
transcription elongation by RNA polymerase II	1
positive regulation of DNA-templated transcription, elongation	1
regulation of transcription elongation by RNA polymerase II	1
transcription preinitiation complex assembly	1
regulation of transcription initiation by RNA polymerase II	1
positive regulation of DNA-templated transcription initiation	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
transcription regulator activity	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
core mediator complex	1
nuclear protein-containing complex	1
RNA polymerase II transcription regulator complex	1

Protein interactions and networks

STRING

1181 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MED22	MED11	Q9P086	999
MED22	MED8	Q96G25	996
MED22	MED6	O75586	996
MED22	MED17	Q9NVC6	994
MED22	MED18	Q9BUE0	991
MED22	MED20	Q9H944	984
MED22	MED30	Q96HR3	983
MED22	MED10	Q9BTT4	971
MED22	MED27	Q6P2C8	946
MED22	SURF6	O75683	918
MED22	MED14	O60244	906
MED22	MED7	O43513	896
MED22	RPL7A	P11518	893
MED22	MED15	Q96RN5	878
MED22	MED16	Q9Y2X0	866

IntAct

125 interactions, top by confidence:

A	B	Type	Score
MED10	MED19	psi-mi:“MI:0914”(association)	0.910
MED10	MED19	psi-mi:“MI:0915”(physical association)	0.910
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
MED4	MED19	psi-mi:“MI:0914”(association)	0.900
CDK8	MED14	psi-mi:“MI:0914”(association)	0.900
MED29	MED19	psi-mi:“MI:0914”(association)	0.890
MED21	MED19	psi-mi:“MI:0914”(association)	0.880
MED17	MED22	psi-mi:“MI:0914”(association)	0.860
MED17	MED22	psi-mi:“MI:0915”(physical association)	0.860
MED22	MED17	psi-mi:“MI:0915”(physical association)	0.860
CDK8	MED19	psi-mi:“MI:2364”(proximity)	0.850
CDK8	MED19	psi-mi:“MI:0914”(association)	0.850

BioGRID (228): MED22 (Affinity Capture-MS), MED22 (Affinity Capture-MS), MED22 (Affinity Capture-MS), MED22 (Affinity Capture-MS), MED22 (Affinity Capture-MS), MED22 (Affinity Capture-MS), MED22 (Co-fractionation), MED22 (Co-fractionation), MED22 (Co-fractionation), MED22 (Co-fractionation), MED22 (Co-fractionation), MED22 (Affinity Capture-Western), MED22 (Synthetic Growth Defect), MED22 (Proximity Label-MS), MED22 (Proximity Label-MS)

ESM2 similar proteins: A0A5F9C6I2, A0JPN6, A4IIZ9, A5WUL3, D3ZUQ0, D3ZXK7, F1R7R1, O43513, O57595, O75916, P51593, P53349, P68943, P85299, Q08DY8, Q13233, Q15528, Q17QG3, Q2F7Z4, Q2TBN4, Q2YDF2, Q3B8I4, Q3T123, Q5BJ48, Q5E9K2, Q5EBL4, Q5FVG6, Q5RKN3, Q5XIX8, Q5XPI3, Q5XPI4, Q62276, Q62739, Q6GQ95, Q6QB00, Q6ZUS6, Q7TMY8, Q7ZV35, Q800L3, Q80U62

Diamond homologs: A0JPN6, A5WUL3, O57595, Q15528, Q178E6, Q23679, Q54XB0, Q5E9K2, Q62276, Q626S1, Q6GQ95, Q7QB45, Q800L3, Q8LCH5, Q9SA42, Q9V439

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MED22	“form complex”	“Core mediator complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 55 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Respiratory Syncytial Virus Infection Pathway	26	121.9×	2e-49
RSV-host interactions	26	96.8×	1e-46
Adipogenesis	26	96.8×	1e-46
Regulation of lipid metabolism by PPARalpha	26	87.3×	2e-45
Transcriptional regulation of white adipocyte differentiation	26	80.3×	2e-44
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	15	77.0×	3e-24
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	15	70.3×	1e-23
PPARA activates gene expression	26	58.4×	2e-40

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of transcription elongation by RNA polymerase II	22	147.1×	2e-42
RNA polymerase II preinitiation complex assembly	22	132.9×	1e-41
positive regulation of transcription initiation by RNA polymerase II	22	132.9×	1e-41
somatic stem cell population maintenance	11	60.6×	1e-15
transcription initiation at RNA polymerase II promoter	7	58.2×	1e-09
protein ubiquitination	11	10.1×	3e-07
transcription by RNA polymerase II	5	7.8×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

195 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	2
Uncertain significance	146
Likely benign	6
Benign	5

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
599495	NM_014815.4(MED24):c.1247C>G (p.Thr416Ser)	Likely pathogenic
599496	NM_014815.4(MED24):c.2288G>A (p.Arg763Gln)	Likely pathogenic

SpliceAI

4973 predictions. Top by Δscore:

Variant	Effect	Δscore
17:40019776:GGTAC:G	donor_loss	1.0000
17:40019777:GTACT:G	donor_loss	1.0000
17:40019778:TAC:T	donor_loss	1.0000
17:40019779:ACTC:A	donor_loss	1.0000
17:40019780:CTC:C	donor_loss	1.0000
17:40019781:T:TG	donor_loss	1.0000
17:40019782:CACG:C	donor_loss	1.0000
17:40019783:A:AC	donor_gain	1.0000
17:40019784:C:CA	donor_gain	1.0000
17:40019784:C:T	donor_loss	1.0000
17:40019784:CG:C	donor_gain	1.0000
17:40019784:CGG:C	donor_gain	1.0000
17:40019784:CGGT:C	donor_gain	1.0000
17:40019784:CGGTG:C	donor_gain	1.0000
17:40019934:C:CC	acceptor_gain	1.0000
17:40019943:G:GC	acceptor_gain	1.0000
17:40021949:A:AC	donor_gain	1.0000
17:40021950:C:CC	donor_gain	1.0000
17:40021950:CTCA:C	donor_gain	1.0000
17:40021953:A:AC	donor_gain	1.0000
17:40021954:C:CG	donor_gain	1.0000
17:40021954:CTG:C	donor_gain	1.0000
17:40021981:T:TA	donor_gain	1.0000
17:40022050:TAATC:T	acceptor_gain	1.0000
17:40022051:AATC:A	acceptor_gain	1.0000
17:40022052:ATC:A	acceptor_gain	1.0000
17:40022053:TC:T	acceptor_gain	1.0000
17:40022054:CC:C	acceptor_gain	1.0000
17:40022055:C:CC	acceptor_gain	1.0000
17:40022388:GCCTA:G	donor_loss	1.0000

AlphaMissense

1297 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:133344293:A:G	L82P	0.999
9:133345183:C:G	A65P	0.999
9:133346598:A:G	L22P	0.999
9:133344281:A:G	L86P	0.998
9:133344314:A:G	L75P	0.998
9:133344318:A:G	S74P	0.998
9:133344327:C:G	A71P	0.998
9:133344329:C:G	R70P	0.998
9:133345180:C:G	A66P	0.998
9:133345182:G:T	A65D	0.998
9:133345185:C:G	R64P	0.998
9:133346567:G:C	N32K	0.998
9:133346567:G:T	N32K	0.998
9:133344158:A:G	L127P	0.997
9:133344275:A:G	L88P	0.997
9:133344289:C:A	K83N	0.997
9:133344289:C:G	K83N	0.997
9:133344305:A:G	L78P	0.997
9:133344149:A:G	L130P	0.996
9:133344332:A:T	V69D	0.996
9:133346601:C:G	R21P	0.996
9:133344191:A:G	L116P	0.995
9:133344266:A:C	F91C	0.995
9:133344275:A:T	L88H	0.995
9:133344278:A:T	I87N	0.995
9:133344323:C:T	G72D	0.995
9:133344179:C:G	R120P	0.994
9:133344326:G:T	A71D	0.994
9:133345188:A:T	V63E	0.994
9:133346544:G:T	A40D	0.994

dbSNP variants (sampled 300 via entrez): RS1000034576 (9:133342782 G>A,C), RS1000171207 (9:133346889 G>T), RS1000438055 (9:133347855 A>C,T), RS1000861174 (9:133347994 C>T), RS1001079473 (9:133347738 C>A), RS1001377200 (9:133338188 G>A), RS1001498251 (9:133338979 A>G), RS1002209863 (9:133343104 T>C), RS1002249886 (9:133348033 TC>T), RS1002265289 (9:133337850 G>A,C), RS1002356918 (9:133343026 C>T), RS1002598791 (9:133338995 G>A,C), RS1002652750 (9:133344927 T>C), RS1002726303 (9:133343375 C>G,T), RS1002764919 (9:133349121 T>C)

Disease associations

OMIM: gene MIM:185641 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
complex neurodevelopmental disorder	Moderate	Autosomal recessive

Mondo (1): complex neurodevelopmental disorder (MONDO:0100038)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

29 associations (top):

Study	Trait	p-value
GCST000589_4	White blood cell count	3.000000e-14
GCST001137_10	White blood cell count	9.000000e-35
GCST001137_8	White blood cell count	2.000000e-31
GCST001302_2	White blood cell count	2.000000e-12
GCST001302_4	White blood cell count	1.000000e-12
GCST001793_1	Coagulation factor levels	4.000000e-34
GCST001793_4	Coagulation factor levels	1.000000e-128
GCST002557_5	Neutrophil count	3.000000e-23
GCST002557_6	Neutrophil count	1.000000e-10
GCST004126_2	White blood cell count	9.000000e-11
GCST005024_87	Pursuit maintenance gain	2.000000e-06
GCST005974_6	Neutrophil count	4.000000e-56
GCST007235_9	Pancreatic ductal adenocarcinoma	7.000000e-06
GCST007395_3	Mitochondrial DNA copy number	7.000000e-07
GCST007399_2	Mitochondrial DNA copy number	2.000000e-07
GCST008058_268	Estimated glomerular filtration rate	5.000000e-08
GCST008059_214	Estimated glomerular filtration rate	7.000000e-08
GCST008103_61	Bipolar disorder	6.000000e-07
GCST008916_21	Asthma	2.000000e-62
GCST008916_36	Asthma	6.000000e-13
GCST008916_85	Asthma	2.000000e-12
GCST009731_5	Blood protein levels in cardiovascular risk	2.000000e-16
GCST010002_123	Refractive error	1.000000e-24
GCST010725_19	Malaria	9.000000e-11
GCST010725_31	Malaria	9.000000e-21
GCST010725_98	Malaria	1.000000e-19
GCST90002381_115	Eosinophil count	2.000000e-16
GCST90002399_237	Neutrophil percentage of white cells	3.000000e-53
GCST90002407_133	White blood cell count	7.000000e-54

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004833	neutrophil count
EFO:0008433	pursuit maintenance gain measurement
EFO:0006312	mitochondrial DNA measurement
EFO:0007774	thrombomodulin measurement
EFO:0004842	eosinophil count
EFO:0007990	neutrophil percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
pirinixic acid	decreases expression, increases activity, affects binding	1
sodium arsenite	increases expression	1
cobaltous chloride	decreases expression	1
nickel sulfate	increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
pyrimidifen	decreases expression	1
pyrachlostrobin	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
NSC 689534	affects binding, decreases expression	1
Leflunomide	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Cisplatin	affects cotreatment, increases expression	1
Copper	decreases expression, affects binding	1
Doxorubicin	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Rotenone	decreases expression	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Valproic Acid	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT06310681	Not specified	COMPLETED	Pilot Testing of a Co-adapted Group Programme for Parents/Carers of Children With Complex Neurodisability
NCT07303049	Not specified	NOT_YET_RECRUITING	Cognitive Benefit of Intensive Rehabilitation Using Rhythmic Music Training in Children With Complex Neurodevelopmental Disorder