MEF2C-AS1

Summary

MEF2C-AS1 (MEF2C antisense RNA 1, HGNC:48908) is a long non-coding RNA gene on chromosome 5q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48908
Approved symbol	MEF2C-AS1
Name	MEF2C antisense RNA 1
Location	5q14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248309
Ensembl biotype	lncRNA
Entrez	101929423
RNAcentral	URS000075BB0E — lncRNA, 1797 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 221 — 221 lncRNA

ENST00000506665, ENST00000508521, ENST00000508718, ENST00000508742, ENST00000509179, ENST00000511100, ENST00000511876, ENST00000512585, ENST00000513704, ENST00000514011, ENST00000514092, ENST00000514158, ENST00000514571, ENST00000514794, ENST00000639552, ENST00000684854, ENST00000684894, ENST00000685027, ENST00000685645, ENST00000686604, ENST00000687485, ENST00000688169, ENST00000688814, ENST00000689963, ENST00000690169, ENST00000691164, ENST00000691685, ENST00000692315, ENST00000700807, ENST00000700959, ENST00000701379, ENST00000701413, ENST00000701972, ENST00000702018, ENST00000702026, ENST00000702112, ENST00000702120, ENST00000786612, ENST00000786613, ENST00000786614, ENST00000786615, ENST00000786616, ENST00000786617, ENST00000786618, ENST00000786619, ENST00000786620, ENST00000786621, ENST00000786622, ENST00000786623, ENST00000786624, ENST00000786625, ENST00000786626, ENST00000786627, ENST00000786628, ENST00000786629, ENST00000786630, ENST00000786631, ENST00000786632, ENST00000786633, ENST00000786634, ENST00000786635, ENST00000786636, ENST00000786637, ENST00000786638, ENST00000786639, ENST00000786640, ENST00000786641, ENST00000786642, ENST00000786643, ENST00000786644, ENST00000786645, ENST00000786646, ENST00000786647, ENST00000786648, ENST00000786649, ENST00000786650, ENST00000786651, ENST00000786652, ENST00000786653, ENST00000786654, ENST00000786655, ENST00000786656, ENST00000786657, ENST00000786658, ENST00000786659, ENST00000786660, ENST00000786661, ENST00000786662, ENST00000786663, ENST00000786664, ENST00000786665, ENST00000786666, ENST00000786667, ENST00000786668, ENST00000786669, ENST00000786670, ENST00000786671, ENST00000786672, ENST00000786673, ENST00000786674, ENST00000786675, ENST00000786676, ENST00000786677, ENST00000786678, ENST00000786679, ENST00000786680, ENST00000786681, ENST00000786682, ENST00000786683, ENST00000786684, ENST00000786685, ENST00000786686, ENST00000786687, ENST00000786688, ENST00000786689, ENST00000786690, ENST00000786691, ENST00000786692, ENST00000786693, ENST00000786694, ENST00000786695, ENST00000786696, ENST00000786697, ENST00000786698, ENST00000786699, ENST00000786700, ENST00000786701, ENST00000786702, ENST00000786703, ENST00000786704, ENST00000786705, ENST00000786706, ENST00000786707, ENST00000786708, ENST00000786709, ENST00000786710, ENST00000786711, ENST00000786712, ENST00000786713, ENST00000786714, ENST00000786715, ENST00000786716, ENST00000786717, ENST00000786718, ENST00000786719, ENST00000786720, ENST00000786721, ENST00000786722, ENST00000786724, ENST00000786725, ENST00000786726, ENST00000786727, ENST00000786728, ENST00000786729, ENST00000786730, ENST00000786731, ENST00000786732, ENST00000786733, ENST00000786734, ENST00000786735, ENST00000786736, ENST00000786737, ENST00000786738, ENST00000786739, ENST00000786740, ENST00000786741, ENST00000786742, ENST00000786743, ENST00000786744, ENST00000786745, ENST00000786746, ENST00000786747, ENST00000786748, ENST00000786749, ENST00000786750, ENST00000786751, ENST00000786752, ENST00000786753, ENST00000786754, ENST00000786755, ENST00000786756, ENST00000786757, ENST00000786758, ENST00000786759, ENST00000786760, ENST00000786761, ENST00000786762, ENST00000786763, ENST00000786764, ENST00000786765, ENST00000786766, ENST00000786767, ENST00000786768, ENST00000786769, ENST00000786770, ENST00000786771, ENST00000786772, ENST00000786773, ENST00000786774, ENST00000786775, ENST00000786776, ENST00000786777, ENST00000786778, ENST00000786779, ENST00000786780, ENST00000786781, ENST00000786782, ENST00000786783, ENST00000786784, ENST00000786785, ENST00000786786, ENST00000786787, ENST00000786788, ENST00000786789, ENST00000786790, ENST00000786791, ENST00000786792, ENST00000786793, ENST00000786794, ENST00000786795, ENST00000786796

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000506665 — 4 exons

Exon	Start	End
ENSE00002034714	88965841	88965896
ENSE00002046014	88892257	88892277
ENSE00002234851	88905209	88905270
ENSE00002315750	88903938	88904160

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 89.19.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4325 / max 41.2517, expressed in 426 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57503	0.7361	302
57502	0.4680	211
57501	0.1864	101
203624	0.0420	11

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	89.19	gold quality
left ovary	UBERON:0002119	87.00	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.44	gold quality
right ovary	UBERON:0002118	85.44	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.85	gold quality
adrenal tissue	UBERON:0018303	83.59	gold quality
tendon	UBERON:0000043	83.40	gold quality
cortical plate	UBERON:0005343	83.40	gold quality
muscle of leg	UBERON:0001383	83.37	gold quality
body of uterus	UBERON:0009853	82.85	gold quality
gastrocnemius	UBERON:0001388	82.83	gold quality
popliteal artery	UBERON:0002250	82.20	gold quality
tibial artery	UBERON:0007610	82.18	gold quality
colonic epithelium	UBERON:0000397	81.96	gold quality
anterior cingulate cortex	UBERON:0009835	81.77	gold quality
right coronary artery	UBERON:0001625	81.51	gold quality
bone marrow cell	CL:0002092	81.46	gold quality
aorta	UBERON:0000947	81.39	gold quality
endocervix	UBERON:0000458	81.26	gold quality
left testis	UBERON:0004533	81.05	gold quality
ascending aorta	UBERON:0001496	80.96	gold quality
thoracic aorta	UBERON:0001515	80.82	gold quality
descending thoracic aorta	UBERON:0002345	80.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.50	gold quality
right lobe of thyroid gland	UBERON:0001119	80.41	gold quality
right testis	UBERON:0004534	80.31	gold quality
muscle layer of sigmoid colon	UBERON:0035805	80.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	80.15	gold quality
smooth muscle tissue	UBERON:0001135	80.11	gold quality
right frontal lobe	UBERON:0002810	80.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MEF2C-AS1 regulates its nearby gene MEF2C to mediate cervical cancer cell malignant phenotypes in vitro. (PMID:36198203)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.