MEG8

Summary

MEG8 (maternally expressed 8, small nucleolar RNA host gene, HGNC:14574) is a long non-coding RNA gene on chromosome 14q32.31.

This gene is located in a cluster of imprinted genes on chromosome 14q32.3. It encodes a a non-protein coding transcript that is preferentially expressed from the maternal allele in skeletal muscle, and appears to be coordinately regulated with other imprinted genes in this region.

Source: NCBI Gene 79104 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14574
Approved symbol	MEG8
Name	maternally expressed 8, small nucleolar RNA host gene
Location	14q32.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00024, Irm, Rian, Bsr, LINC00024, AL132709.8, lnc-MGC
Ensembl gene	ENSG00000225746
Ensembl biotype	lncRNA
OMIM	613648
Entrez	79104
RNAcentral	URS0000EEDA45 — lncRNA, 5564 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 65 — 65 lncRNA

ENST00000414488, ENST00000423708, ENST00000427085, ENST00000434716, ENST00000442197, ENST00000443252, ENST00000553421, ENST00000553465, ENST00000553584, ENST00000554323, ENST00000554369, ENST00000554485, ENST00000554693, ENST00000554852, ENST00000555354, ENST00000556475, ENST00000556637, ENST00000556720, ENST00000636052, ENST00000636391, ENST00000637332, ENST00000638012, ENST00000648818, ENST00000649300, ENST00000653102, ENST00000654340, ENST00000655773, ENST00000656987, ENST00000657772, ENST00000658511, ENST00000660698, ENST00000661496, ENST00000661815, ENST00000662228, ENST00000662832, ENST00000663218, ENST00000664819, ENST00000665015, ENST00000665480, ENST00000665787, ENST00000666001, ENST00000666972, ENST00000667813, ENST00000667814, ENST00000668102, ENST00000668545, ENST00000668595, ENST00000668725, ENST00000669238, ENST00000670454, ENST00000670680, ENST00000670877, ENST00000699458, ENST00000699459, ENST00000741820, ENST00000741821, ENST00000741822, ENST00000741823, ENST00000741824, ENST00000741825, ENST00000741826, ENST00000741827, ENST00000741828, ENST00000789029, ENST00000789030

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414488 — 8 exons

Exon	Start	End
ENSE00001602356	100958262	100958550
ENSE00003976622	100953964	100954046
ENSE00003976623	100954922	100955006
ENSE00003976626	100950402	100950472
ENSE00003976629	100951432	100951494
ENSE00003976631	100949515	100949596
ENSE00003976634	100948978	100949039
ENSE00004079349	100955885	100955949

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 99.63.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3559 / max 35.1756, expressed in 160 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141570	0.2328	103
141573	0.0987	32
141565	0.0244	10

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.63	gold quality
calcaneal tendon	UBERON:0003701	97.99	gold quality
adenohypophysis	UBERON:0002196	94.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.81	gold quality
pituitary gland	UBERON:0000007	93.00	gold quality
sural nerve	UBERON:0015488	92.05	gold quality
right adrenal gland	UBERON:0001233	90.26	gold quality
right adrenal gland cortex	UBERON:0035827	89.93	gold quality
left ovary	UBERON:0002119	89.92	gold quality
left adrenal gland cortex	UBERON:0035825	89.87	gold quality
left adrenal gland	UBERON:0001234	89.03	gold quality
adrenal cortex	UBERON:0001235	88.05	gold quality
adrenal gland	UBERON:0002369	88.05	gold quality
tendon	UBERON:0000043	87.90	gold quality
hypothalamus	UBERON:0001898	87.64	gold quality
right ovary	UBERON:0002118	87.55	gold quality
colonic epithelium	UBERON:0000397	86.92	gold quality
anterior cingulate cortex	UBERON:0009835	85.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.27	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.24	gold quality
cerebellar hemisphere	UBERON:0002245	84.36	gold quality
cerebellar cortex	UBERON:0002129	84.34	gold quality
right frontal lobe	UBERON:0002810	84.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.80	gold quality
nucleus accumbens	UBERON:0001882	83.22	gold quality
amygdala	UBERON:0001876	82.82	gold quality
ovary	UBERON:0000992	82.78	gold quality
cerebellum	UBERON:0002037	82.25	gold quality
stromal cell of endometrium	CL:0002255	81.74	gold quality
body of pancreas	UBERON:0001150	80.55	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	18.26
E-HCAD-25	yes	7.86

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NEUROG2

Literature-anchored findings (GeneRIF, showing 16)

• MEG8, located in a cluster of imprinted genes on chromosome 14q32.3, is preferentially expressed from the maternal allele. (PMID:11337479)
• MEG8-DMR is hypermethylated in each of 13 non-deletion Temple syndrome patients. (PMID:28635951)
• Endogenous MEG8 lncRNA is indispensable for TGF-beta-induced epithelial-mesenchymal transition in A549 lung cancer and Panc1 pancreatic cancer cells. (PMID:30262664)
• MEG8 regulates the proliferation and migration of VSMCs via the MEG8/miR-181a/PPARalpha axis. (PMID:30670309)
• Meg8 suppresses hepatic stellate cells activation and hepatocyte epithelial-mesenchymal transition through inhibiting the Notch pathway. (PMID:31711641)
• LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis. (PMID:32649368)
• LncRNA MEG8 plays an oncogenic role in hepatocellular carcinoma progression through miR-367-3p/14-3-3zeta/TGFbetaR1 axis. (PMID:33147050)
• LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury. (PMID:33189541)
• Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis. (PMID:33742531)
• Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis. (PMID:33839417)
• LncRNA MEG8 promotes TNF-alpha expression by sponging miR-454-3p in bone-invasive pituitary adenomas. (PMID:34016788)
• Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms’ Tumor Cells through Mediating miR-23a-3p/CRK Axis. (PMID:34518485)
• Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR203induced mediation of the Notch signaling pathway. (PMID:34713294)
• MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium. (PMID:35039572)
• MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers. (PMID:35578848)
• LncRNA MEG8 ameliorates Parkinson’s disease neuro-inflammation through miR-485-3p/FBXO45 axis. (PMID:37814093)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.