MEIOB

Summary

MEIOB (meiosis specific with OB-fold, HGNC:28569) is a protein-coding gene on chromosome 16p13.3, encoding Meiosis-specific with OB domain-containing protein (Q8N635). Single-stranded DNA-binding protein required for homologous recombination in meiosis I.

Predicted to enable chromatin binding activity; single-stranded DNA 3’-5’ DNA exonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Located in nucleus. Implicated in primary ovarian insufficiency and spermatogenic failure 22.

Source: NCBI Gene 254528 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spermatogenic failure 22 (Strong, GenCC) — +2 more curated relationships
• Clinical variants (ClinVar): 75 total — 7 pathogenic
• Phenotypes (HPO): 17
• MANE Select transcript: NM_001163560

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28569
Approved symbol	MEIOB
Name	meiosis specific with OB-fold
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC35212
Ensembl gene	ENSG00000162039
Ensembl biotype	protein_coding
OMIM	617670
Entrez	254528

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000325962, ENST00000397344, ENST00000460494, ENST00000470044, ENST00000490154, ENST00000496541

RefSeq mRNA: 2 — MANE Select: NM_001163560 NM_001163560, NM_152764

CCDS: CCDS10449, CCDS53983

Canonical transcript exons

ENST00000325962 — 14 exons

Exon	Start	End
ENSE00001720077	1865778	1865835
ENSE00002580569	1868107	1868184
ENSE00003502950	1860403	1860475
ENSE00003507198	1854100	1854200
ENSE00003555382	1857735	1857930
ENSE00003692541	1861985	1862116
ENSE00003775899	1853219	1853271
ENSE00003776654	1844862	1844963
ENSE00003776967	1853039	1853134
ENSE00003779199	1839255	1839438
ENSE00003780017	1841820	1841973
ENSE00003783583	1837784	1837870
ENSE00003904058	1833986	1834366
ENSE00003904279	1871993	1872164

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 93.50.

FANTOM5 (CAGE): breadth broad, TPM avg 4.0929 / max 172.4691, expressed in 274 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155876	4.0929	274

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	93.50	gold quality
left testis	UBERON:0004533	92.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.30	gold quality
testis	UBERON:0000473	90.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.52	gold quality
cartilage tissue	UBERON:0002418	69.88	gold quality
adult organism	UBERON:0007023	67.49	gold quality
sperm	CL:0000019	65.40	silver quality
tibia	UBERON:0000979	61.89	gold quality
right lobe of liver	UBERON:0001114	61.83	gold quality
lower esophagus mucosa	UBERON:0035834	61.03	gold quality
mucosa of transverse colon	UBERON:0004991	60.60	gold quality
secondary oocyte	CL:0000655	59.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.73	gold quality
prefrontal cortex	UBERON:0000451	57.99	gold quality
anterior cingulate cortex	UBERON:0009835	57.67	gold quality
amygdala	UBERON:0001876	57.59	gold quality
islet of Langerhans	UBERON:0000006	57.41	gold quality
lower lobe of lung	UBERON:0008949	57.31	silver quality
hypothalamus	UBERON:0001898	56.53	gold quality
nucleus accumbens	UBERON:0001882	56.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.24	gold quality
right frontal lobe	UBERON:0002810	56.08	gold quality
right coronary artery	UBERON:0001625	55.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.07	gold quality
adult mammalian kidney	UBERON:0000082	54.99	gold quality
spinal cord	UBERON:0002240	54.76	gold quality
skin of abdomen	UBERON:0001416	54.56	gold quality
skin of leg	UBERON:0001511	54.45	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	742.87
E-ANND-3	yes	4.05

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

39 targeting MEIOB, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6516-3P	99.65	68.57	1238

Literature-anchored findings (GeneRIF, showing 9)

• we propose that RPA and this new single-strand DNA binding protein MEIOB, are essential to ensure the proper stabilization of recombinases which is required for successful homology search and meiotic recombination. (PMID:24068956)
• MEIOB interacts with RPA and SPATA22. (PMID:24240703)
• MEIOB is the major, and most likely also the exclusive, contributor of the testicular pathology found in the seven non-obstructive azoospermia patients across two studies. (PMID:30838384)
• This truncating MEIOB variant is expected to provoke meiotic defects and a depleted follicular stock, as in Meiob(-/-) mice. This is the first molecular defect reported in a meiosis-specific single-stranded DNA-binding protein (SSB) responsible for POI. (PMID:31000419)
• The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination. (PMID:33166385)
• The cancer-testis gene, MEIOB, sensitizes triple-negative breast cancer to PARP1 inhibitors by inducing homologous recombination deficiency. (PMID:33628586)
• The meiosis-specific MEIOB-SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex. (PMID:33812231)
• Whole-exome sequencing of consanguineous families with infertile men and women identifies homologous mutations in SPATA22 and MEIOB. (PMID:34392356)
• Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22. (PMID:36331299)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	meiob	ENSDARG00000062442
mus_musculus	Meiob	ENSMUSG00000024155
rattus_norvegicus	Meiob	ENSRNOG00000014711
drosophila_melanogaster	hdm	FBGN0029977

Protein

Protein identifiers

Meiosis-specific with OB domain-containing protein — Q8N635 (reviewed: Q8N635)

All UniProt accessions (4): Q8N635, H3BSU6, H3BU10, H3BU18

UniProt curated annotations — full annotation on UniProt →

Function. Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity in vitro.

Subunit / interactions. Component of a multiprotein complex with RPA2 and SPATA22. Interacts with SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2.

Subcellular location. Cytoplasm. Nucleus. Chromosome.

Tissue specificity. In fetal gonads, specifically expressed in the ovary starting at the 14th weeks post fertilization. In the adult, restricted to testis.

Disease relevance. Spermatogenic failure 22 (SPGF22) [MIM:617706] An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia. The disease is caused by variants affecting the gene represented in this entry. Premature ovarian failure 23 (POF23) [MIM:620686] A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF23 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the MEIOB family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N635-1	1	yes
Q8N635-2	2

RefSeq proteins (2): NP_001157032, NP_689977 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR052469	MEIOB	Family
IPR056880	OB_MEIOB_N	Domain

Pfam: PF24903

UniProt features (9 total): sequence variant 6, chain 1, DNA-binding region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N635-F1	81.00	0.44

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 119 (showing top): GOBP_MEIOTIC_CHROMOSOME_SEGREGATION, GOBP_CHROMOSOME_ORGANIZATION, GOMF_NUCLEASE_ACTIVITY, GOBP_MALE_GAMETE_GENERATION, GOBP_ORGANELLE_FISSION, GOBP_DNA_DAMAGE_RESPONSE, GOBP_MALE_MEIOSIS_I, GOBP_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE, GOBP_FEMALE_GAMETE_GENERATION, GOBP_HOMOLOGOUS_CHROMOSOME_SEGREGATION, GOBP_MEIOTIC_CELL_CYCLE_PROCESS, GOBP_FERTILIZATION, GOBP_RECOMBINATIONAL_REPAIR, GOMF_EXONUCLEASE_ACTIVITY, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN

GO Biological Process (8): resolution of meiotic recombination intermediates (GO:0000712), double-strand break repair via homologous recombination (GO:0000724), homologous chromosome pairing at meiosis (GO:0007129), male meiotic nuclear division (GO:0007140), male meiosis I (GO:0007141), female meiosis I (GO:0007144), fertilization (GO:0009566), meiotic cell cycle (GO:0051321)

GO Molecular Function (8): chromatin binding (GO:0003682), single-stranded DNA binding (GO:0003697), single-stranded DNA 3’-5’ DNA exonuclease activity (GO:0008310), DNA binding (GO:0003677), nuclease activity (GO:0004518), exonuclease activity (GO:0004527), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (3): nucleus (GO:0005634), chromosome (GO:0005694), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
meiotic cell cycle	3
male gamete generation	2
meiotic nuclear division	2
meiosis I	2
sexual reproduction	2
reproductive process	2
binding	2
reciprocal meiotic recombination	1
meiosis I cell cycle process	1
recombinational repair	1
double-strand break repair	1
homologous chromosome segregation	1
chromosome organization involved in meiotic cell cycle	1
male meiotic nuclear division	1
female meiotic nuclear division	1
female gamete generation	1
cell cycle	1
DNA binding	1
3’-5’-DNA exonuclease activity	1
single-stranded DNA exodeoxyribonuclease activity	1
nucleic acid binding	1
catalytic activity, acting on a nucleic acid	1
nuclease activity	1
hydrolase activity, acting on ester bonds	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2058 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MEIOB	SPATA22	Q8NHS9	968
MEIOB	SPO11	Q9Y5K1	706
MEIOB	SYCE1	Q8N0S2	700
MEIOB	HSF2BP	O75031	689
MEIOB	SYCP3	Q8IZU3	688
MEIOB	TEX11	Q8IYF3	684
MEIOB	TEX15	Q9BXT5	653
MEIOB	SYCE3	A1L190	646
MEIOB	SWSAP1	Q6NVH7	642
MEIOB	HFM1	A2PYH4	636
MEIOB	HORMAD1	Q86X24	636
MEIOB	MSH4	O15457	627
MEIOB	STAG3	Q9UJ98	620
MEIOB	HORMAD2	Q8N7B1	613
MEIOB	BRME1	Q0VDD7	609

IntAct

4 interactions, top by confidence:

A	B	Type	Score
MEIOB	GAPDHS	psi-mi:“MI:0915”(physical association)	0.590
CFTR	MEIOB	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (8): GAPDHS (Affinity Capture-MS), GAPDHS (Affinity Capture-MS), MEIOB (Two-hybrid), GAPDHS (Affinity Capture-MS), MEIOB (Negative Genetic), MEIOB (PCA), MEIOB (Affinity Capture-RNA), MEIOB (Affinity Capture-MS)

ESM2 similar proteins: A1KXW8, A6QL50, E1BGQ2, H0Y354, O94955, P47224, Q08326, Q0IIH8, Q1JQA1, Q1RMS8, Q1RMZ1, Q2TBU5, Q3T1H6, Q4R372, Q4R528, Q4R9C4, Q5F480, Q5F4A1, Q5I0G3, Q5RCQ0, Q5RFG8, Q5TFE4, Q5TYM5, Q641X7, Q6L9T8, Q6PIP5, Q7L622, Q7Z6J8, Q7ZX59, Q86X60, Q8BFZ8, Q8BKW4, Q8BM85, Q8BX13, Q8CEL2, Q8N5C7, Q8N635, Q8NHU2, Q8TCF1, Q8TCJ0

Diamond homologs: B0BMX9, Q4R8G6, Q8N635, Q9D513

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

75 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	7
Likely pathogenic	0
Uncertain significance	51
Likely benign	3
Benign	6

Top pathogenic / likely-pathogenic (7)

Variant ID	HGVS	Classification
1328958	NM_001163560.3(MEIOB):c.1118_1121del (p.Phe373fs)	Pathogenic
2045761	NM_001163560.3(MEIOB):c.814C>T (p.Arg272Ter)	Pathogenic
2691778	NM_001163560.3(MEIOB):c.976G>A (p.Ala326Thr)	Pathogenic
2691780	NM_001163560.3(MEIOB):c.683-1G>A	Pathogenic
2691783	NM_001163560.3(MEIOB):c.528+3A>C	Pathogenic
440759	NM_001163560.3(MEIOB):c.191A>T (p.Asn64Ile)	Pathogenic
4849218	NM_001163560.3(MEIOB):c.673C>T (p.Arg225Ter)	Pathogenic

SpliceAI

2186 predictions. Top by Δscore:

Variant	Effect	Δscore
16:1834363:CGAA:C	acceptor_gain	1.0000
16:1834367:C:CC	acceptor_gain	1.0000
16:1837782:A:AC	donor_gain	1.0000
16:1837783:C:CC	donor_gain	1.0000
16:1837806:T:A	donor_gain	1.0000
16:1839238:T:TA	donor_gain	1.0000
16:1839285:T:TA	donor_gain	1.0000
16:1841816:TTACC:T	donor_loss	1.0000
16:1841817:T:TG	donor_loss	1.0000
16:1841818:A:AC	donor_gain	1.0000
16:1841818:A:C	donor_loss	1.0000
16:1841819:C:CC	donor_gain	1.0000
16:1841819:CCAT:C	donor_gain	1.0000
16:1841970:CTTA:C	acceptor_gain	1.0000
16:1841971:TTA:T	acceptor_gain	1.0000
16:1841972:TA:T	acceptor_gain	1.0000
16:1841972:TACTA:T	acceptor_loss	1.0000
16:1841973:ACTAA:A	acceptor_loss	1.0000
16:1841974:C:CA	acceptor_loss	1.0000
16:1841974:C:CC	acceptor_gain	1.0000
16:1844855:CACT:C	donor_loss	1.0000
16:1844856:ACTT:A	donor_loss	1.0000
16:1844857:CTTA:C	donor_loss	1.0000
16:1844858:T:TC	donor_loss	1.0000
16:1844859:TA:T	donor_loss	1.0000
16:1844860:A:AC	donor_gain	1.0000
16:1844860:ACA:A	donor_loss	1.0000
16:1844861:C:CC	donor_gain	1.0000
16:1844861:C:T	donor_loss	1.0000
16:1844861:CA:C	donor_gain	1.0000

AlphaMissense

3124 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:1862077:C:G	R56P	0.997
16:1853268:C:A	W211C	0.995
16:1853268:C:G	W211C	0.995
16:1853270:A:G	W211R	0.994
16:1853270:A:T	W211R	0.994
16:1862042:A:G	W68R	0.993
16:1862042:A:T	W68R	0.993
16:1865819:A:T	V29D	0.993
16:1853237:A:G	W222R	0.992
16:1853237:A:T	W222R	0.992
16:1862040:C:A	W68C	0.992
16:1862040:C:G	W68C	0.992
16:1853131:A:T	I229K	0.990
16:1865791:A:C	F38L	0.990
16:1865791:A:T	F38L	0.990
16:1865793:A:G	F38L	0.990
16:1853077:G:T	A247E	0.989
16:1854136:A:G	L198P	0.989
16:1860420:G:C	F105L	0.988
16:1860420:G:T	F105L	0.988
16:1860422:A:G	F105L	0.988
16:1857748:G:T	A172E	0.987
16:1862086:A:G	F53S	0.987
16:1865825:C:T	G27D	0.986
16:1854142:A:T	V196D	0.985
16:1857749:C:G	A172P	0.985
16:1839323:C:G	D384H	0.983
16:1865826:C:G	G27R	0.982
16:1853131:A:C	I229R	0.981
16:1854101:A:G	C210R	0.981

dbSNP variants (sampled 300 via entrez): RS1000010350 (16:1854295 C>A), RS1000022022 (16:1836988 C>G), RS1000037678 (16:1854564 G>A), RS1000472736 (16:1838682 T>G), RS1000475237 (16:1870999 G>A), RS1000546544 (16:1849338 A>G), RS1000651136 (16:1848929 C>T), RS1000653945 (16:1837831 C>T), RS1000762555 (16:1843642 C>T), RS1000798782 (16:1843954 T>G), RS1000803527 (16:1868763 G>A,C), RS1000910237 (16:1867093 A>G,T), RS1000938271 (16:1849101 A>G), RS1001059099 (16:1858762 C>A), RS1001192388 (16:1854377 G>A)

Disease associations

OMIM: gene MIM:617670 | disease phenotypes: MIM:617706, MIM:620686

GenCC curated gene-disease

Disease	Classification	Inheritance
spermatogenic failure 22	Strong	Autosomal recessive
premature ovarian failure 23	Strong	Autosomal recessive
male infertility with azoospermia or oligozoospermia due to single gene mutation	Supportive	Autosomal dominant

Mondo (4): azoospermia (MONDO:0100459), spermatogenic failure 22 (MONDO:0054726), premature ovarian failure 23 (MONDO:0958035), (MONDO:0018393)

Orphanet (0):

HPO phenotypes

17 total (17 of 17 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000027	Azoospermia
HP:0000118	Phenotypic abnormality
HP:0000837	Increased circulating gonadotropin level
HP:0000869	Secondary amenorrhea
HP:0000876	Oligomenorrhea
HP:0003251	Male infertility
HP:0008222	Female infertility
HP:0008232	Elevated circulating follicle stimulating hormone level
HP:0008669	Abnormal spermatogenesis
HP:0008734	Decreased testicular size
HP:0011462	Young adult onset
HP:0011961	Non-obstructive azoospermia
HP:0011962	Obstructive azoospermia
HP:0030974	Cryptozoospermia
HP:0031103	Decreased circulating antimullerian hormone circulation
HP:0033085	Reduced antral follicle count

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D053713	Azoospermia	C12.100.500.430.380; C12.100.750.700.380; C12.200.294.430.380

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects expression, decreases expression	3
mercuric bromide	decreases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
fluorene-9-bisphenol	increases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
Decitabine	affects expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases expression	1
Cisplatin	affects expression	1
Tretinoin	decreases expression	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

27 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02307994	PHASE4	UNKNOWN	Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH
NCT02275169	PHASE3	UNKNOWN	FSH Treatment for Non-obstructive Azoospermic Patients
NCT02544191	PHASE2	UNKNOWN	GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
NCT03762967	PHASE2	UNKNOWN	Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility
NCT02041910	PHASE1/PHASE2	UNKNOWN	Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia
NCT00282477	Not specified	UNKNOWN	Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls
NCT00484081	Not specified	COMPLETED	Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
NCT00548977	Not specified	COMPLETED	Genetic Studies Spermatogenic Failure
NCT01375062	Not specified	COMPLETED	Obtaining Undifferentiated Cells From Testis Biopsy
NCT01509482	Not specified	COMPLETED	Insulin Resistance in Idiopathic Oligospermia and Azoospermia
NCT02008799	Not specified	UNKNOWN	Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia
NCT02339272	Not specified	COMPLETED	Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility
NCT02414295	Not specified	COMPLETED	Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection
NCT02418832	Not specified	RECRUITING	Testis Needle Aspiration of Sperm in Men With Azoospermia
NCT02617173	Not specified	UNKNOWN	The Effect of Low Electrical Current on Testicular Spermatocyte Count
NCT02773498	Not specified	TERMINATED	Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track
NCT03497728	Not specified	TERMINATED	Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients
NCT04675164	Not specified	COMPLETED	Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men
NCT05479474	Not specified	RECRUITING	Platelet Rich Plasma Testis Treatment for Infertile Men
NCT05628987	Not specified	RECRUITING	The Association of Gut Microbiota and Spermatogenic Dysfunction
NCT05866484	Not specified	COMPLETED	Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS)
NCT06524258	Not specified	COMPLETED	Testicular Elastography for Microscopic Testicular Sperm Extraction
NCT06841328	Not specified	RECRUITING	Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
NCT06941922	Not specified	RECRUITING	Testicular Evaluation of Azoospermia Using Micro-Ultrasound
NCT07074015	Not specified	RECRUITING	IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens
NCT07357701	Not specified	RECRUITING	Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
NCT07542626	Not specified	RECRUITING	Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue