MEIOC

Summary

MEIOC (meiosis specific with coiled-coil domain, HGNC:26670) is a protein-coding gene on chromosome 17q21.31, encoding Meiosis-specific coiled-coil domain-containing protein MEIOC (A2RUB1). Is required for meiosis completion in both male and female germ cells.

Predicted to be involved in several processes, including germ cell development; germline cell cycle switching, mitotic to meiotic cell cycle; and meiosis I. Predicted to be active in cytoplasm and nucleus.

Source: NCBI Gene 284071 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 10 total
• MANE Select transcript: NM_001145080

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26670
Approved symbol	MEIOC
Name	meiosis specific with coiled-coil domain
Location	17q21.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ35848
Ensembl gene	ENSG00000180336
Ensembl biotype	protein_coding
OMIM	616934
Entrez	284071

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000409122, ENST00000409464, ENST00000425535, ENST00000432494, ENST00000456912, ENST00000472403, ENST00000588805, ENST00000856682

RefSeq mRNA: 1 — MANE Select: NM_001145080 NM_001145080

CCDS: CCDS45703

Canonical transcript exons

ENST00000409122 — 8 exons

Exon	Start	End
ENSE00001581856	44656468	44656682
ENSE00001586412	44673976	44675801
ENSE00001686325	44662317	44662471
ENSE00001757625	44657127	44657261
ENSE00002850517	44669383	44669517
ENSE00002893932	44673366	44673546
ENSE00003463175	44666376	44668233
ENSE00003535661	44665384	44665488

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 92.41.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9012 / max 121.3419, expressed in 186 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161183	0.5826	140
161181	0.2682	87
161182	0.0399	14
161185	0.0104	5

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	92.41	gold quality
right testis	UBERON:0004534	91.32	gold quality
left testis	UBERON:0004533	90.90	gold quality
testis	UBERON:0000473	88.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.60	gold quality
secondary oocyte	CL:0000655	82.16	gold quality
adult organism	UBERON:0007023	79.58	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.74	gold quality
sperm	CL:0000019	74.86	silver quality
cerebellar hemisphere	UBERON:0002245	72.23	gold quality
cerebellar cortex	UBERON:0002129	72.01	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.18	gold quality
gastrocnemius	UBERON:0001388	70.85	gold quality
muscle of leg	UBERON:0001383	70.29	gold quality
cerebellum	UBERON:0002037	69.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.49	gold quality
monocyte	CL:0000576	67.04	gold quality
leukocyte	CL:0000738	66.82	gold quality
cortical plate	UBERON:0005343	66.65	gold quality
right frontal lobe	UBERON:0002810	65.76	gold quality
anterior cingulate cortex	UBERON:0009835	65.70	gold quality
prefrontal cortex	UBERON:0000451	65.11	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.66	gold quality
metanephros cortex	UBERON:0010533	63.19	gold quality
ganglionic eminence	UBERON:0004023	63.02	gold quality
stromal cell of endometrium	CL:0002255	62.93	gold quality
oocyte	CL:0000023	62.78	gold quality
calcaneal tendon	UBERON:0003701	62.38	gold quality
nucleus accumbens	UBERON:0001882	62.24	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.38
E-MTAB-6142	no	40.20

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

149 targeting MEIOC, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877

Literature-anchored findings (GeneRIF, showing 1)

• Meioc is expressed in germ cells during meiotic prophase I. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs. (PMID:26742488)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	moto	ENSDARG00000090664
mus_musculus	Meioc	ENSMUSG00000051455
rattus_norvegicus	Meioc	ENSRNOG00000021953

Protein

Protein identifiers

Meiosis-specific coiled-coil domain-containing protein MEIOC — A2RUB1 (reviewed: A2RUB1)

Alternative names: Meiosis-specific with coiled-coil domain protein

All UniProt accessions (5): A2RUB1, C9J4A2, C9JC06, C9JYK8, K7EPA7

UniProt curated annotations — full annotation on UniProt →

Function. Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.

Subunit / interactions. Interacts with YTHDC2; binds transcript that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normally. Interacts with RBM46.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Expressed in fetal ovaries. Expressed in testis.

Isoforms (4)

UniProt ID	Names	Canonical?
A2RUB1-4	1	yes
A2RUB1-2	2
A2RUB1-1	3
A2RUB1-5	4

RefSeq proteins (1): NP_001138552* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027963	MEIOC	Family

Pfam: PF15189

UniProt features (14 total): region of interest 3, sequence conflict 3, splice variant 3, sequence variant 2, compositionally biased region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A2RUB1-F1	46.49	0.13

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 125 (showing top): GOBP_MEIOTIC_CHROMOSOME_SEGREGATION, GOBP_CHROMOSOME_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS, GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GOBP_CHROMOSOME_LOCALIZATION, GOBP_OOGENESIS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_MALE_GAMETE_GENERATION, GOBP_REGULATION_OF_MEIOTIC_CELL_CYCLE, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE, GOBP_SYNAPTONEMAL_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_FISSION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE

GO Biological Process (12): double-strand break repair (GO:0006302), synaptonemal complex assembly (GO:0007130), male meiosis I (GO:0007141), female meiosis I (GO:0007144), spermatid development (GO:0007286), mRNA stabilization (GO:0048255), oocyte development (GO:0048599), metaphase chromosome alignment (GO:0051310), germline cell cycle switching, mitotic to meiotic cell cycle (GO:0051729), chromosome organization involved in meiotic cell cycle (GO:0070192), spermatogenesis (GO:0007283), meiotic cell cycle (GO:0051321)

GO Molecular Function (0):

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
meiotic cell cycle	3
meiosis I	2
male gamete generation	2
germ cell development	2
DNA repair	1
homologous chromosome pairing at meiosis	1
cellular component assembly	1
chromosome organization involved in meiotic cell cycle	1
synaptonemal complex organization	1
male meiotic nuclear division	1
female meiotic nuclear division	1
female gamete generation	1
spermatid differentiation	1
regulation of mRNA stability	1
RNA stabilization	1
negative regulation of mRNA catabolic process	1
oocyte differentiation	1
chromosome localization	1
nuclear chromosome segregation	1
cell cycle switching, mitotic to meiotic cell cycle	1
chromosome organization	1
meiotic cell cycle process	1
developmental process involved in reproduction	1
cell cycle	1
sexual reproduction	1
reproductive process	1
meiotic nuclear division	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

492 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MEIOC	YTHDC2	Q9H6S0	963
MEIOC	HORMAD2	Q8N7B1	616
MEIOC	HORMAD1	Q86X24	609
MEIOC	STRA8	Q7Z7C7	577
MEIOC	M1AP	Q8TC57	558
MEIOC	YTHDC1	Q96MU7	546
MEIOC	SMC1B	Q8NDV3	541
MEIOC	MEI1	Q5TIA1	539
MEIOC	MEIOB	Q8N635	508
MEIOC	XRN1	Q8IZH2	499
MEIOC	YTHDF2	Q9Y5A9	496
MEIOC	YTHDF3	Q7Z739	492
MEIOC	MAIP1	Q8WWC4	491
MEIOC	SYCP3	Q8IZU3	490
MEIOC	YTHDF1	Q9BYJ9	464

IntAct

10 interactions, top by confidence:

A	B	Type	Score
IQCN	TARS3	psi-mi:“MI:0914”(association)	0.350
DUSP16	MEIOC	psi-mi:“MI:0914”(association)	0.350
NXF2B	MEIOC	psi-mi:“MI:0914”(association)	0.350
ZNF550	MEIOC	psi-mi:“MI:0914”(association)	0.350
TRIM52	MEIOC	psi-mi:“MI:0914”(association)	0.350
SLC20A2	MEIOC	psi-mi:“MI:0914”(association)	0.350
SLC27A5	MEIOC	psi-mi:“MI:0914”(association)	0.350
SLC27A6	NBAS	psi-mi:“MI:0914”(association)	0.350
SLC9A2	MEIOC	psi-mi:“MI:0914”(association)	0.350

BioGRID (27): C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Proximity Label-MS), C17orf104 (Proximity Label-MS), C17orf104 (Proximity Label-MS), C17orf104 (Proximity Label-MS), C17orf104 (Proximity Label-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Affinity Capture-MS), C17orf104 (Negative Genetic)

ESM2 similar proteins: A0A087WRU1, A0JNH1, A2RUB1, A6QNQ6, B0S6S9, B1WC58, D3Z987, D3ZJ47, E1BC15, O60673, P28358, P28359, P56716, P70347, Q0P5X5, Q0VAV2, Q0VBV7, Q15468, Q2M2Z5, Q3UXL4, Q3V089, Q49A88, Q569L8, Q5BQN8, Q5CZC0, Q5QGS0, Q5T1N1, Q5VWN6, Q60988, Q61493, Q62924, Q6ZP01, Q6ZU52, Q6ZVD7, Q80U59, Q80WQ8, Q86WS4, Q86YC2, Q8CB14, Q8IUR6

Diamond homologs: A2AG06, A2RUB1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

10 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2631 predictions. Top by Δscore:

Variant	Effect	Δscore
17:44665381:TA:T	acceptor_loss	1.0000
17:44665382:A:AT	acceptor_loss	1.0000
17:44665382:AG:A	acceptor_gain	1.0000
17:44665383:GG:G	acceptor_gain	1.0000
17:44665460:GA:G	donor_gain	1.0000
17:44665461:A:G	donor_gain	1.0000
17:44665484:GAAGG:G	donor_gain	1.0000
17:44665485:AAGGG:A	donor_loss	1.0000
17:44665487:GG:G	donor_gain	1.0000
17:44665488:GG:G	donor_gain	1.0000
17:44665489:G:GA	donor_loss	1.0000
17:44665490:TTAG:T	donor_loss	1.0000
17:44665491:TAGTA:T	donor_loss	1.0000
17:44665492:AGTA:A	donor_loss	1.0000
17:44669516:GA:G	donor_gain	1.0000
17:44669518:G:GG	donor_gain	1.0000
17:44673516:C:T	donor_gain	1.0000
17:44673542:CAGAG:C	donor_loss	1.0000
17:44673543:AGAGG:A	donor_loss	1.0000
17:44673544:GAG:G	donor_gain	1.0000
17:44673545:AG:A	donor_loss	1.0000
17:44673546:GG:G	donor_loss	1.0000
17:44673547:G:GA	donor_loss	1.0000
17:44673548:T:A	donor_loss	1.0000
17:44673971:TACA:T	acceptor_loss	1.0000
17:44673972:ACAG:A	acceptor_loss	1.0000
17:44673973:CA:C	acceptor_loss	1.0000
17:44673974:A:AG	acceptor_gain	1.0000
17:44673974:AG:A	acceptor_loss	1.0000
17:44673974:AGAT:A	acceptor_gain	1.0000

AlphaMissense

6316 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:44673479:A:C	R857S	0.995
17:44673479:A:T	R857S	0.995
17:44673478:G:C	R857T	0.993
17:44673475:G:C	R856P	0.985
17:44669483:G:C	R808P	0.980
17:44673988:T:C	L884P	0.980
17:44665434:T:C	L137P	0.979
17:44668227:A:C	R772S	0.979
17:44668227:A:T	R772S	0.979
17:44665446:T:C	I141T	0.978
17:44673478:G:T	R857I	0.978
17:44673988:T:A	L884H	0.977
17:44673996:G:C	A887P	0.976
17:44668184:T:C	L758P	0.974
17:44673990:G:C	A885P	0.974
17:44674033:G:C	R899P	0.974
17:44673477:A:G	R857G	0.972
17:44674042:T:C	L902P	0.972
17:44674044:T:A	W903R	0.972
17:44674044:T:C	W903R	0.972
17:44669480:A:T	D807V	0.971
17:44669504:G:C	R815P	0.971
17:44665449:T:C	L142S	0.967
17:44668172:T:C	L754P	0.967
17:44665446:T:G	I141S	0.966
17:44669501:T:C	L814P	0.966
17:44674054:T:C	L906P	0.966
17:44669396:T:C	L779P	0.964
17:44669479:G:C	D807H	0.962
17:44674050:G:C	A905P	0.962

dbSNP variants (sampled 300 via entrez): RS1000018918 (17:44669855 A>C,G), RS1000057692 (17:44659803 C>T), RS1000108245 (17:44659228 A>G), RS1000313568 (17:44677227 T>C), RS1000377619 (17:44667273 T>C), RS1000601804 (17:44677548 G>GC), RS1000731815 (17:44657526 G>A), RS1000745979 (17:44673135 C>G), RS1000861270 (17:44673680 C>A,G), RS1001104824 (17:44657485 G>C), RS1001209730 (17:44669167 C>A), RS1001240855 (17:44661696 C>T), RS1001325540 (17:44668986 A>C,G), RS1001424864 (17:44677214 G>A), RS1001479500 (17:44663929 C>T)

Disease associations

OMIM: gene MIM:616934 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST90002395_260	Mean platelet volume	7.000000e-15
GCST90002400_215	Plateletcrit	2.000000e-16
GCST90002402_406	Platelet count	7.000000e-27

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007985	platelet crit
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation	5
trichostatin A	affects cotreatment, decreases expression, increases expression	2
Vorinostat	decreases expression, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
methylmercuric chloride	increases expression	1
arsenite	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
clothianidin	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression, decreases expression	1
Arsenic Trioxide	decreases expression	1
Air Pollutants	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Carbamazepine	affects expression	1
Cisplatin	affects cotreatment, increases expression	1
Smoke	increases expression	1
Triiodothyronine	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	decreases expression	1
Cadmium Chloride	decreases expression, increases abundance	1
S-Nitrosoglutathione	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.