MELTF-AS1

Summary

MELTF-AS1 (MELTF antisense RNA 1, HGNC:40373) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40373
Approved symbol	MELTF-AS1
Name	MELTF antisense RNA 1
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC068302.3, PLANE
Ensembl gene	ENSG00000228109
Ensembl biotype	lncRNA
Entrez	100507057
RNAcentral	URS000009863C — lncRNA, 951 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000414354, ENST00000415244, ENST00000424769, ENST00000437064, ENST00000446695, ENST00000773016

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414354 — 3 exons

Exon	Start	End
ENSE00001797488	197003602	197003970
ENSE00004137610	197003137	197003206
ENSE00004137612	197004494	197004748

Expression profiles

Bgee: expression breadth ubiquitous, 232 present calls, max score 97.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5049 / max 78.1647, expressed in 1085 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40762	1.0258	552
40761	0.8878	523
203079	0.4980	264
40760	0.0933	20

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	97.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.07	gold quality
pituitary gland	UBERON:0000007	96.66	gold quality
right testis	UBERON:0004534	96.65	gold quality
cerebellar hemisphere	UBERON:0002245	96.49	gold quality
left testis	UBERON:0004533	96.37	gold quality
cerebellar cortex	UBERON:0002129	96.35	gold quality
cerebellum	UBERON:0002037	95.45	gold quality
testis	UBERON:0000473	94.07	gold quality
right frontal lobe	UBERON:0002810	93.11	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.81	gold quality
left ovary	UBERON:0002119	92.44	gold quality
right uterine tube	UBERON:0001302	92.25	gold quality
putamen	UBERON:0001874	92.23	gold quality
amygdala	UBERON:0001876	92.19	gold quality
caudate nucleus	UBERON:0001873	91.95	gold quality
anterior cingulate cortex	UBERON:0009835	91.52	gold quality
parotid gland	UBERON:0001831	91.50	gold quality
right ovary	UBERON:0002118	91.46	gold quality
endocervix	UBERON:0000458	91.16	gold quality
nucleus accumbens	UBERON:0001882	90.86	gold quality
right lobe of thyroid gland	UBERON:0001119	90.40	gold quality
left lobe of thyroid gland	UBERON:0001120	90.13	gold quality
hypothalamus	UBERON:0001898	90.09	gold quality
body of uterus	UBERON:0009853	89.98	gold quality
ganglionic eminence	UBERON:0004023	89.56	gold quality
thyroid gland	UBERON:0002046	89.50	gold quality
ventricular zone	UBERON:0003053	89.50	gold quality
tibial nerve	UBERON:0001323	89.44	gold quality
brain	UBERON:0000955	89.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• results indicated lncRNA MFI2 could promote proliferation and migration of osteosarcoma cells by regulating FOXP4 expression, which suggested critical roles of lncRNA MFI2 and FOXP4 in occurrence and development of human osteosarcoma (PMID:27513470)
• Long non-coding RNA MFI2-AS1 expression was associated with dramatically increased risk of relapse compared to patients with undetectable MFI2-AS1 who had favorable outcomes. (PMID:28819235)
• Up-regulation of long non-coding RNA MFI2 functions as an oncogenic role in cervical cancer progression. (PMID:31210294)
• MFI2-AS1 regulates the aggressive phenotypes in glioma by modulating MMP14 via a positive feedback loop. (PMID:31298339)
• Knockdown of MFI2-AS1 increased cell viability but suppressed apoptosis, inflammatory response and extracellular matrix degradation in LPS-treated chondrocytes by increasing miR-130a-3p and decreasing TCF4, indicating a novel target for the treatment of osteoarthritis (PMID:31678554)
• LncRNA MFI2-AS1 promotes HCC progression and metastasis by acting as a competing endogenous RNA of miR-134 to upregulate FOXM1 expression. (PMID:32106369)
• Long non-coding MELTF Antisense RNA 1 promotes and prognosis the progression of non-small cell lung cancer by targeting miR-1299. (PMID:35441579)
• Copy number amplification and SP1-activated lncRNA MELTF-AS1 regulates tumorigenesis by driving phase separation of YBX1 to activate ANXA8 in non-small cell lung cancer. (PMID:35508543)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.