MESTIT1

Summary

MESTIT1 (MEST intronic transcript 1, antisense RNA, HGNC:17991) is a long non-coding RNA gene on chromosome 7q32.2.

This gene encodes a non-protein coding antisense RNA that is imprinted, and preferentially expressed from the paternal allele. It is located in an intron of MEST gene in the opposite orientation, and shares the promoter region in common with one of the promoters (P2) of MEST gene. The antisense RNA is expressed predominantly in testis and mature motile spermatozoa, suggesting that it may be involved in the regulation of MEST expression during development.

Source: NCBI Gene 317751 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17991
Approved symbol	MESTIT1
Name	MEST intronic transcript 1, antisense RNA
Location	7q32.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00040, MEST-AS1
Ensembl gene	ENSG00000272701
Ensembl biotype	lncRNA
OMIM	607794
Entrez	317751
RNAcentral	URS0000DBB579 — lncRNA, 4062 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000610046, ENST00000648778

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000610046 — 2 exons

Exon	Start	End
ENSE00003708010	130486042	130489967
ENSE00003772944	130490842	130491033

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 65.78.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	65.78	gold quality
tonsil	UBERON:0002372	60.26	silver quality
ventricular zone	UBERON:0003053	58.87	silver quality
ganglionic eminence	UBERON:0004023	58.51	gold quality
right testis	UBERON:0004534	57.88	gold quality
testis	UBERON:0000473	56.86	gold quality
left testis	UBERON:0004533	56.82	gold quality
prefrontal cortex	UBERON:0000451	55.44	gold quality
nucleus accumbens	UBERON:0001882	55.09	gold quality
pituitary gland	UBERON:0000007	54.81	gold quality
caudate nucleus	UBERON:0001873	54.45	gold quality
pancreas	UBERON:0001264	53.59	gold quality
adenohypophysis	UBERON:0002196	53.36	gold quality
frontal cortex	UBERON:0001870	53.34	gold quality
temporal lobe	UBERON:0001871	53.01	gold quality
amygdala	UBERON:0001876	52.92	gold quality
putamen	UBERON:0001874	52.30	gold quality
brain	UBERON:0000955	52.02	gold quality
smooth muscle tissue	UBERON:0001135	51.60	gold quality
cerebral cortex	UBERON:0000956	51.52	gold quality
monocyte	CL:0000576	51.43	silver quality
anterior cingulate cortex	UBERON:0009835	51.37	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	51.01	gold quality
blood	UBERON:0000178	50.97	gold quality
right frontal lobe	UBERON:0002810	50.73	gold quality
hypothalamus	UBERON:0001898	50.07	gold quality
superior frontal gyrus	UBERON:0002661	50.05	gold quality
omental fat pad	UBERON:0010414	49.86	gold quality
liver	UBERON:0002107	49.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MESTIT1, encoding a non-protein coding antisense RNA, is imprinted, with preferential expression from the paternal allele in all fetal tissues and fibroblasts examined. (PMID:12095916)
• It can be excluded that genomic variants in MESTIT1 are involved in the aetiology of Silver-Russell syndrome (PMID:12746419)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.