METTL14-DT

Summary

METTL14-DT (METTL14 divergent transcript, HGNC:53367) is a long non-coding RNA gene on chromosome 4q26.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53367
Approved symbol	METTL14-DT
Name	METTL14 divergent transcript
Location	4q26
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000281731
Ensembl biotype	lncRNA
Entrez	101929741
RNAcentral	URS00007E4A1C — lncRNA, 1571 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000628457, ENST00000629093, ENST00000629462, ENST00000655315, ENST00000657708, ENST00000660319, ENST00000660577, ENST00000660675, ENST00000664083, ENST00000665753, ENST00000667475, ENST00000668247, ENST00000669615, ENST00000670296, ENST00000736704, ENST00000736705, ENST00000736706, ENST00000736707, ENST00000736708, ENST00000736709, ENST00000736710, ENST00000736711, ENST00000736712, ENST00000736713

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000628457 — 5 exons

Exon	Start	End
ENSE00002088560	118673499	118673593
ENSE00003761591	118680489	118680583
ENSE00003866121	118684408	118685313
ENSE00003872072	118677290	118677341
ENSE00003874189	118664168	118665199

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 78.85.

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.85	gold quality
right testis	UBERON:0004534	75.72	gold quality
left testis	UBERON:0004533	74.82	gold quality
testis	UBERON:0000473	72.27	gold quality
bone marrow cell	CL:0002092	63.69	silver quality
Brodmann (1909) area 9	UBERON:0013540	63.69	gold quality
anterior cingulate cortex	UBERON:0009835	63.60	gold quality
nucleus accumbens	UBERON:0001882	63.43	gold quality
sural nerve	UBERON:0015488	63.13	silver quality
right lobe of liver	UBERON:0001114	63.11	gold quality
right frontal lobe	UBERON:0002810	62.53	gold quality
caudate nucleus	UBERON:0001873	62.48	gold quality
putamen	UBERON:0001874	61.75	gold quality
adenohypophysis	UBERON:0002196	61.49	gold quality
hypothalamus	UBERON:0001898	61.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.13	gold quality
pituitary gland	UBERON:0000007	60.08	gold quality
ventricular zone	UBERON:0003053	59.94	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.73	gold quality
amygdala	UBERON:0001876	59.54	gold quality
cortical plate	UBERON:0005343	59.34	gold quality
prefrontal cortex	UBERON:0000451	59.24	gold quality
right lobe of thyroid gland	UBERON:0001119	59.17	gold quality
left lobe of thyroid gland	UBERON:0001120	58.80	gold quality
ganglionic eminence	UBERON:0004023	58.61	gold quality
thyroid gland	UBERON:0002046	58.58	gold quality
monocyte	CL:0000576	58.50	gold quality
leukocyte	CL:0000738	58.24	gold quality
neocortex	UBERON:0001950	58.07	gold quality
spinal cord	UBERON:0002240	57.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.