METTL15

Summary

METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine, HGNC:26606) is a protein-coding gene on chromosome 11p14.1, encoding 12S rRNA N(4)-cytidine methyltransferase METTL15 (A6NJ78). N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. It is a selective cancer dependency (DepMap: 25.4% of cell lines).

Enables rRNA (cytosine-N4-)-methyltransferase activity. Involved in rRNA base methylation. Is active in mitochondrial matrix.

Source: NCBI Gene 196074 — RefSeq curated summary.

At a glance

• GWAS associations: 26
• Clinical variants (ClinVar): 72 total
• Cancer dependency (DepMap): dependent in 25.4% of screened cell lines
• MANE Select transcript: NM_001113528

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26606
Approved symbol	METTL15
Name	methyltransferase 15, mitochondrial 12S rRNA N4-cytidine
Location	11p14.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ33979
Ensembl gene	ENSG00000169519
Ensembl biotype	protein_coding
OMIM	618711
Entrez	196074

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 11 protein_coding, 5 nonsense_mediated_decay, 1 retained_intron

ENST00000303459, ENST00000403099, ENST00000406787, ENST00000407364, ENST00000437814, ENST00000451385, ENST00000468295, ENST00000532947, ENST00000634627, ENST00000634721, ENST00000634762, ENST00000634973, ENST00000886889, ENST00000886890, ENST00000886891, ENST00000886892, ENST00000954982

RefSeq mRNA: 3 — MANE Select: NM_001113528 NM_001113528, NM_001297775, NM_152636

CCDS: CCDS31450, CCDS44559, CCDS73269

Canonical transcript exons

ENST00000407364 — 7 exons

Exon	Start	End
ENSE00001554114	28110166	28110401
ENSE00001562480	28108388	28108452
ENSE00002172085	28113318	28113604
ENSE00003460501	28290206	28290397
ENSE00003558262	28211062	28211198
ENSE00003577865	28330396	28333507
ENSE00003646324	28296753	28296931

Expression profiles

Bgee: expression breadth ubiquitous, 238 present calls, max score 89.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.2699 / max 322.0710, expressed in 1800 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
113558	13.4282	1777
113557	5.8416	1608

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	89.55	gold quality
calcaneal tendon	UBERON:0003701	88.86	gold quality
left ventricle myocardium	UBERON:0006566	88.44	silver quality
kidney epithelium	UBERON:0004819	86.17	silver quality
colonic epithelium	UBERON:0000397	84.72	gold quality
cardiac muscle of right atrium	UBERON:0003379	84.46	gold quality
tibialis anterior	UBERON:0001385	84.07	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.19	gold quality
islet of Langerhans	UBERON:0000006	81.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.24	gold quality
muscle of leg	UBERON:0001383	80.86	gold quality
rectum	UBERON:0001052	80.78	gold quality
tendon	UBERON:0000043	80.75	gold quality
right adrenal gland cortex	UBERON:0035827	80.69	gold quality
gastrocnemius	UBERON:0001388	80.58	gold quality
adrenal gland	UBERON:0002369	80.16	gold quality
right adrenal gland	UBERON:0001233	80.01	gold quality
right uterine tube	UBERON:0001302	79.99	gold quality
left adrenal gland	UBERON:0001234	79.78	gold quality
bone marrow cell	CL:0002092	79.76	gold quality
ventricular zone	UBERON:0003053	79.74	gold quality
deltoid	UBERON:0001476	79.39	silver quality
tibial artery	UBERON:0007610	79.34	gold quality
popliteal artery	UBERON:0002250	79.33	gold quality
left adrenal gland cortex	UBERON:0035825	79.29	gold quality
pancreas	UBERON:0001264	79.16	gold quality
stromal cell of endometrium	CL:0002255	78.72	gold quality
adrenal cortex	UBERON:0001235	78.37	gold quality
smooth muscle tissue	UBERON:0001135	78.30	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-46	yes	15.61
E-ANND-3	yes	5.76
E-MTAB-6142	no	81.95

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

123 targeting METTL15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-6809-3P	99.91	71.45	3814

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 25.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• The human mitochondrial 12S rRNA m(4)C methyltransferase METTL15 is required for mitochondrial function. (PMID:32371392)
• Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development. (PMID:37715994)
• The catalytic activity of methyltransferase METTL15 is dispensable for its role in mitochondrial ribosome biogenesis. (PMID:38913872)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mettl15	ENSDARG00000089236
mus_musculus	Mettl15	ENSMUSG00000057234
rattus_norvegicus	Mettl15	ENSRNOG00000066683
drosophila_melanogaster	CG14683	FBGN0037822

Protein

Protein identifiers

12S rRNA N(4)-cytidine methyltransferase METTL15 — A6NJ78 (reviewed: A6NJ78)

Alternative names: Methyltransferase 5 domain-containing protein 1, Methyltransferase-like protein 15

All UniProt accessions (7): A0A0U1RR64, A0A0U1RR76, A0A0U1RRD2, A0A0U1RRF2, A6NJ78, B5MC64, F8WD83

UniProt curated annotations — full annotation on UniProt →

Function. N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.

Subcellular location. Mitochondrion matrix.

Similarity. Belongs to the methyltransferase superfamily. RsmH family.

Isoforms (4)

UniProt ID	Names	Canonical?
A6NJ78-1	1	yes
A6NJ78-2	2
A6NJ78-3	3
A6NJ78-4	4

RefSeq proteins (3): NP_001107000, NP_001284704, NP_689849 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002903	RsmH	Family
IPR023397	SAM-dep_MeTrfase_MraW_recog	Homologous_superfamily
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily

Pfam: PF01795

Catalyzed reactions (Rhea), 1 shown:

• cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine + H(+) (RHEA:62524)

UniProt features (52 total): helix 19, strand 8, splice variant 6, binding site 5, sequence variant 3, mutagenesis site 3, turn 3, sequence conflict 2, transit peptide 1, chain 1, modified residue 1

Structure

Experimental structures (PDB)

13 structures.

PDB	Method	Resolution (Å)
8IPK	X-RAY DIFFRACTION	1.9
8IPI	X-RAY DIFFRACTION	2.1
8IPL	X-RAY DIFFRACTION	2.2
7PNX	ELECTRON MICROSCOPY	2.76
9G5C	ELECTRON MICROSCOPY	3
9G5D	ELECTRON MICROSCOPY	3
7PNY	ELECTRON MICROSCOPY	3.06
7PNZ	ELECTRON MICROSCOPY	3.09
8IPM	X-RAY DIFFRACTION	3.1
9H51	ELECTRON MICROSCOPY	3.1
8QRL	ELECTRON MICROSCOPY	3.34
9IGU	ELECTRON MICROSCOPY	3.64
9IGT	ELECTRON MICROSCOPY	5.96

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NJ78-F1	79.90	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 100–102; 119; 146; 169; 176

Post-translational modifications (1): 358

Mutagenesis-validated functional residues (3):

Position	Phenotype
98–101	abolished methylation of 12s rrna position c839.
119–120	absence of methylation of 12s rrna position c839 and decreased methylation at position c841.
298	decreased methylation of 12s rrna positions c839 and c841.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 157 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_RIBOSOME_ASSEMBLY, GOBP_RNA_METHYLATION, GOBP_RNA_MODIFICATION, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, CCCAGAG_MIR326, GOBP_RRNA_MODIFICATION, GOBP_METHYLATION, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY, GOBP_RRNA_METHYLATION, NUYTTEN_EZH2_TARGETS_DN, GOCC_MITOCHONDRIAL_MATRIX

GO Biological Process (3): rRNA base methylation (GO:0070475), mitochondrial small ribosomal subunit assembly (GO:0180026), methylation (GO:0032259)

GO Molecular Function (4): rRNA (cytosine-N4-)-methyltransferase activity (GO:0071424), protein binding (GO:0005515), methyltransferase activity (GO:0008168), transferase activity (GO:0016740)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
rRNA methylation	1
ribosomal small subunit assembly	1
mitochondrial ribosome assembly	1
metabolic process	1
N-methyltransferase activity	1
rRNA (cytosine) methyltransferase activity	1
binding	1
transferase activity, transferring one-carbon groups	1
catalytic activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1794 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
METTL15	TRMT2B	Q96GJ1	695
METTL15	MRM3	Q9HC36	693
METTL15	NSUN4	Q96CB9	650
METTL15	METTL5	Q9NRN9	644
METTL15	TFB1M	Q8WVM0	609
METTL15	RPUSD4	Q96CM3	602
METTL15	RBFA	Q8N0V3	592
METTL15	MRM1	Q6IN84	584
METTL15	METTL17	Q9H7H0	581
METTL15	MRM2	Q9UI43	570
METTL15	METTL16	Q86W50	563
METTL15	DIMT1	Q9UNQ2	547
METTL15	METTL1	Q9UBP6	539
METTL15	MPV17L2	Q567V2	532
METTL15	ERAL1	O75616	520

IntAct

107 interactions, top by confidence:

A	B	Type	Score
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
KLHL22	TMEM223	psi-mi:“MI:0914”(association)	0.640
KLHL22	METTL15	psi-mi:“MI:0914”(association)	0.640
METTL15	MVB12B	psi-mi:“MI:0915”(physical association)	0.590
MAS1	POTEF	psi-mi:“MI:0914”(association)	0.530
GYPB	TCAF2	psi-mi:“MI:0914”(association)	0.530
CD79A	METTL15	psi-mi:“MI:0914”(association)	0.530
APLNR	METTL15	psi-mi:“MI:0914”(association)	0.530
SLC15A1	METTL15	psi-mi:“MI:0914”(association)	0.530
IL13RA2	METTL15	psi-mi:“MI:0914”(association)	0.530
RBFA	METTL15	psi-mi:“MI:0914”(association)	0.530
KIR3DL2	METTL15	psi-mi:“MI:0914”(association)	0.530
SLC2A12	METTL15	psi-mi:“MI:0914”(association)	0.530
EMILIN1	METTL15	psi-mi:“MI:0914”(association)	0.530
LAMP3	METTL15	psi-mi:“MI:0914”(association)	0.530
LIPT1	METTL15	psi-mi:“MI:0914”(association)	0.530
CXCR4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
CD70	METTL15	psi-mi:“MI:0914”(association)	0.530

BioGRID (317): METTL15 (Two-hybrid), MVB12B (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS), METTL15 (Affinity Capture-MS)

ESM2 similar proteins: A0JN95, A4IF87, A6NJ78, B5DEQ3, B7ZMP1, D3ZLY0, E9Q4Z2, F1QDI9, G1SPE9, O14717, O15228, O22268, O55055, O95453, O95671, P37287, P69341, P97770, Q05B63, Q08J23, Q0V8R7, Q0VGM9, Q10D00, Q1HFZ0, Q2T9W2, Q4G073, Q5R5T5, Q5R962, Q5R9W8, Q5RC51, Q5RJZ1, Q6GR37, Q6H1L8, Q6NYU2, Q6YJI5, Q7TNK6, Q7YS61, Q7Z4G4, Q8JZM0, Q8R2Y8

Diamond homologs: A0JN95, A0L5N9, A1AU69, A1AZK1, A1UTD3, A3PHR7, A4WQC5, A5EPL2, A5FUK2, A5G8K8, A5VDD4, A5VRI5, A6NJ78, A6WZP8, A7HVT9, A7IGF4, A8GP28, A8GVV6, A8HZ68, A8LSB5, A9H0G9, A9M698, A9VW37, A9WG80, B0CHM8, B0T839, B0TGB2, B0UFI0, B0X4T2, B1LYT9, B1Z8U3, B2IGF2, B2S6R2, B3E3Z0, B3QFN9, B4RFS8, B6IRH0, B6JCF0, B7KU77, B8G5X3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3851 predictions. Top by Δscore:

Variant	Effect	Δscore
11:28108451:GGGT:G	donor_gain	1.0000
11:28108452:GGTG:G	donor_gain	1.0000
11:28211060:A:AG	acceptor_gain	1.0000
11:28211061:G:GT	acceptor_gain	1.0000
11:28211061:GA:G	acceptor_gain	1.0000
11:28211061:GAT:G	acceptor_gain	1.0000
11:28211061:GATT:G	acceptor_gain	1.0000
11:28211061:GATTT:G	acceptor_gain	1.0000
11:28211194:TATCC:T	donor_gain	1.0000
11:28211195:ATCC:A	donor_gain	1.0000
11:28211195:ATCCG:A	donor_loss	1.0000
11:28211196:TCC:T	donor_gain	1.0000
11:28211197:CC:C	donor_gain	1.0000
11:28211198:CG:C	donor_loss	1.0000
11:28211199:G:GG	donor_gain	1.0000
11:28211199:GTAA:G	donor_loss	1.0000
11:28211200:T:TC	donor_loss	1.0000
11:28211201:A:AG	donor_loss	1.0000
11:28290191:T:A	acceptor_gain	1.0000
11:28290192:G:A	acceptor_gain	1.0000
11:28290204:A:AG	acceptor_gain	1.0000
11:28290205:G:GA	acceptor_gain	1.0000
11:28290396:AGG:A	donor_loss	1.0000
11:28290397:GGT:G	donor_loss	1.0000
11:28290398:G:GA	donor_loss	1.0000
11:28290399:T:G	donor_loss	1.0000
11:28296927:TGCAG:T	donor_loss	1.0000
11:28296928:GCAG:G	donor_loss	1.0000
11:28296929:CAG:C	donor_loss	1.0000
11:28296930:AGGTA:A	donor_loss	1.0000

AlphaMissense

2657 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:28290348:T:C	F184L	0.998
11:28290350:T:A	F184L	0.998
11:28290350:T:G	F184L	0.998
11:28330578:T:C	F321L	0.998
11:28330580:C:A	F321L	0.998
11:28330580:C:G	F321L	0.998
11:28330591:A:T	E325V	0.997
11:28290349:T:C	F184S	0.996
11:28330592:G:C	E325D	0.996
11:28330592:G:T	E325D	0.996
11:28330606:A:T	K330I	0.996
11:28296926:T:A	V258D	0.995
11:28330496:C:A	N293K	0.995
11:28330496:C:G	N293K	0.995
11:28330813:C:A	A399D	0.995
11:28290234:T:C	F146L	0.994
11:28290236:C:A	F146L	0.994
11:28290236:C:G	F146L	0.994
11:28290305:T:A	D169E	0.994
11:28290305:T:G	D169E	0.994
11:28330470:T:C	F285L	0.994
11:28330472:C:A	F285L	0.994
11:28330472:C:G	F285L	0.994
11:28330593:G:C	D326H	0.994
11:28330594:A:C	D326A	0.994
11:28290385:T:C	M196T	0.993
11:28330459:C:A	A281D	0.993
11:28330597:G:C	R327P	0.993
11:28290304:A:C	D169A	0.992
11:28290386:G:A	M196I	0.992

dbSNP variants (sampled 300 via entrez): RS1000004230 (11:28327806 C>A), RS1000006181 (11:28285582 A>G,T), RS1000013594 (11:28219960 T>C), RS1000014506 (11:28171437 G>A,T), RS1000020002 (11:28418713 C>T), RS1000024101 (11:28355359 A>G), RS1000047587 (11:28331133 G>A,T), RS1000058725 (11:28250282 C>A,G,T), RS1000069978 (11:28286101 C>A,G,T), RS1000083884 (11:28510000 A>G), RS1000083937 (11:28163474 T>C), RS1000091385 (11:28158455 A>C), RS1000092410 (11:28208022 A>G), RS1000100712 (11:28294982 G>A,C), RS1000102197 (11:28464438 G>T)

Disease associations

OMIM: gene MIM:618711 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

26 associations (top):

Study	Trait	p-value
GCST001762_711	Obesity-related traits	9.000000e-06
GCST006291_48	Spherical equivalent or myopia (age of diagnosis)	1.000000e-11
GCST007094_40	Diastolic blood pressure	1.000000e-06
GCST007099_157	Systolic blood pressure	3.000000e-08
GCST007323_16	Risk-taking tendency (4-domain principal component model)	8.000000e-09
GCST007323_92	Risk-taking tendency (4-domain principal component model)	1.000000e-09
GCST007324_143	Adventurousness	3.000000e-10
GCST007325_186	General risk tolerance (MTAG)	1.000000e-08
GCST007325_37	General risk tolerance (MTAG)	4.000000e-08
GCST007325_74	General risk tolerance (MTAG)	6.000000e-10
GCST007326_13	Number of sexual partners	2.000000e-08
GCST007326_80	Number of sexual partners	4.000000e-08
GCST007327_174	Smoking status (ever vs never smokers)	5.000000e-13
GCST007559_11	Sleep duration (short sleep)	2.000000e-09
GCST007576_181	Chronotype	6.000000e-10
GCST008156_66	Hip circumference adjusted for BMI	4.000000e-06
GCST009363_50	Triglyceride levels x short total sleep time interaction (2df test)	2.000000e-08
GCST009380_4	Type 2 diabetes (adjusted for BMI)	5.000000e-08
GCST009725_80	Intraocular pressure	2.000000e-07
GCST010002_233	Refractive error	7.000000e-16
GCST010463_21	Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism	5.000000e-06
GCST010989_94	Body size at age 10	1.000000e-09
GCST010989_95	Body size at age 10	3.000000e-11
GCST011494_54	Daytime nap	4.000000e-10
GCST012090_37	Major depressive disorder (MTAG)	3.000000e-10
GCST90002409_22	Childhood body mass index	5.000000e-07

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0003939	energy intake
EFO:0004847	age at onset
EFO:0006336	diastolic blood pressure
EFO:0006335	systolic blood pressure
EFO:0008579	risk-taking behaviour
EFO:0004318	smoking behavior
EFO:0008328	chronotype measurement
EFO:0008039	BMI-adjusted hip circumference
EFO:0004530	triglyceride measurement
EFO:0004695	intraocular pressure measurement
EFO:0009819	comparative body size at age 10, self-reported
EFO:0007828	daytime rest measurement
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
beta-lapachone	decreases expression	1
mono-(2-ethylhexyl)phthalate	increases abundance, increases methylation	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
jinfukang	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Diethylhexyl Phthalate	increases abundance, increases methylation	1
Doxorubicin	decreases expression	1
Herbicides	affects methylation, increases abundance	1
Hydrogen Peroxide	affects cotreatment, increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methyl Methanesulfonate	increases expression	1
Picloram	increases abundance, affects methylation	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Theophylline	affects cotreatment, increases expression	1
Urethane	increases expression	1
Valproic Acid	decreases methylation, increases expression	1
Aflatoxin B1	decreases expression, increases methylation	1
Copper Sulfate	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SX94	HAP1 METTL15 (-) 1	Cancer cell line	Male
CVCL_SX95	HAP1 METTL15 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.