METTL26

Summary

METTL26 (methyltransferase like 26, HGNC:14141) is a protein-coding gene on chromosome 16p13.3, encoding Methyltransferase-like 26 (Q96S19).

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 17 total
• MANE Select transcript: NM_032366

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14141
Approved symbol	METTL26
Name	methyltransferase like 26
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC13114
Ensembl gene	ENSG00000130731
Ensembl biotype	protein_coding
Entrez	84326

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 24 protein_coding, 3 nonsense_mediated_decay, 2 retained_intron

ENST00000301686, ENST00000338401, ENST00000397664, ENST00000397665, ENST00000397666, ENST00000448973, ENST00000456420, ENST00000564039, ENST00000565163, ENST00000565799, ENST00000568077, ENST00000568773, ENST00000568830, ENST00000614890, ENST00000861830, ENST00000861831, ENST00000861832, ENST00000861833, ENST00000861834, ENST00000861835, ENST00000861836, ENST00000861837, ENST00000861838, ENST00000861839, ENST00000924031, ENST00000924032, ENST00000924033, ENST00000956705, ENST00000956706

RefSeq mRNA: 6 — MANE Select: NM_032366 NM_001040160, NM_001040161, NM_001040162, NM_001040165, NM_001288710, NM_032366

CCDS: CCDS32352, CCDS42090, CCDS42091, CCDS45367, CCDS45368, CCDS73798

Canonical transcript exons

ENST00000301686 — 6 exons

Exon	Start	End
ENSE00002317067	635612	635774
ENSE00003487696	634889	634956
ENSE00003489126	634719	634797
ENSE00003494732	634430	634644
ENSE00003523513	635281	635340
ENSE00003849123	636094	636305

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 97.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 72.0986 / max 367.9163, expressed in 1820 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155744	69.7438	1820
207692	0.9571	497
155743	0.8591	438
207690	0.2826	134
207691	0.2560	114

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	97.65	gold quality
anterior cingulate cortex	UBERON:0009835	97.62	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.62	gold quality
right frontal lobe	UBERON:0002810	97.49	gold quality
amygdala	UBERON:0001876	97.18	gold quality
putamen	UBERON:0001874	97.12	gold quality
nucleus accumbens	UBERON:0001882	97.05	gold quality
prefrontal cortex	UBERON:0000451	96.99	gold quality
caudate nucleus	UBERON:0001873	96.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.65	gold quality
mucosa of transverse colon	UBERON:0004991	96.46	gold quality
cerebellar hemisphere	UBERON:0002245	96.38	gold quality
cerebellar cortex	UBERON:0002129	96.37	gold quality
right coronary artery	UBERON:0001625	96.36	gold quality
left adrenal gland cortex	UBERON:0035825	96.00	gold quality
hypothalamus	UBERON:0001898	95.98	gold quality
right adrenal gland	UBERON:0001233	95.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.85	gold quality
left adrenal gland	UBERON:0001234	95.83	gold quality
right adrenal gland cortex	UBERON:0035827	95.78	gold quality
left ovary	UBERON:0002119	95.76	gold quality
right ovary	UBERON:0002118	95.73	gold quality
cerebellum	UBERON:0002037	95.67	gold quality
lower esophagus	UBERON:0013473	95.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	95.57	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.57	gold quality
right uterine tube	UBERON:0001302	95.56	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.91

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mettl26	ENSDARG00000027461
mus_musculus	Mettl26	ENSMUSG00000025731
rattus_norvegicus	Mettl26	ENSRNOG00000021615
drosophila_melanogaster	CG18661	FBGN0040964
caenorhabditis_elegans		WBGENE00012514

Protein

Protein identifiers

Methyltransferase-like 26 — Q96S19 (reviewed: Q96S19)

All UniProt accessions (8): Q96S19, A0A087WYU2, H3BMF3, H3BNB2, H3BNT3, H3BQ55, H3BRT2, H3BS73

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the UPF0585 family.

Isoforms (6)

UniProt ID	Names	Canonical?
Q96S19-1	1	yes
Q96S19-2	2
Q96S19-3	3
Q96S19-4	4
Q96S19-5	5
Q96S19-6	6

RefSeq proteins (6): NP_001035250, NP_001035251, NP_001035252, NP_001035255, NP_001275639, NP_115742* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010342	DUF938	Family
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily

Pfam: PF06080

UniProt features (10 total): splice variant 5, modified residue 2, chain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96S19-F1	97.70	0.99

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 149

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 92 (showing top): CCAWYNNGAAR_UNKNOWN, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, AACWWCAANK_UNKNOWN, PAX8_B, IRF7_01, NIKOLSKY_BREAST_CANCER_16P13_AMPLICON, WANG_TUMOR_INVASIVENESS_DN, COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN, IRITANI_MAD1_TARGETS_DN, KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN, LEE_BMP2_TARGETS_UP, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN, IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP, BRF1_TARGET_GENES, CHAF1B_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

514 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
METTL26	METTL25	Q8N6Q8	553
METTL26	METTL27	Q8N6F8	506
METTL26	NTMT1	Q9BV86	487
METTL26	FAM98C	Q17RN3	480
METTL26	METTL17	Q9H7H0	480
METTL26	SLAIN2	Q9P270	478
METTL26	METTL25B	Q96FB5	477
METTL26	NTMT2	Q5VVY1	453
METTL26	METTL9	Q9H1A3	447
METTL26	METTL2B	Q6P1Q9	431
METTL26	AFMID	Q63HM1	430
METTL26	ZSCAN5B	A6NJL1	418
METTL26	METTL24	Q5JXM2	411
METTL26	METTL6	Q8TCB7	410
METTL26	TMT1B	Q6UX53	401

IntAct

5 interactions, top by confidence:

A	B	Type	Score
DISC1	AGRN	psi-mi:“MI:0914”(association)	0.350
ISCA1	BACH1	psi-mi:“MI:0914”(association)	0.350
METTL26	GOLGA4	psi-mi:“MI:0914”(association)	0.350
RUNX1	METTL26	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (11): C16orf13 (Reconstituted Complex), C16orf13 (Affinity Capture-MS), GOLGA4 (Affinity Capture-MS), RBM12 (Affinity Capture-MS), LZIC (Affinity Capture-MS), MCTS1 (Affinity Capture-MS), C16orf13 (Affinity Capture-MS), C16orf13 (Affinity Capture-MS), C16orf13 (Two-hybrid), MTA2 (Cross-Linking-MS (XL-MS)), SORD (Co-fractionation)

ESM2 similar proteins: A0A0S2CGD3, A0A144Y7G4, A0A162J3X8, A0A1L9WLE6, A0A455LLX2, A0A4V1DXC3, A0AAW1NHX6, A4II73, A5WVX1, A6QLY4, A8Q1U2, B0BML7, M2Y1A3, M2ZIX7, O57314, P18297, P29147, P35270, P40580, P51658, Q02338, Q13268, Q17QK8, Q28IU1, Q3SZ16, Q3SZ73, Q497C3, Q4V8B7, Q5E9H7, Q5RCH4, Q5XG41, Q64105, Q6Q2C2, Q6WAU1, Q7SYS6, Q7ZY31, Q8AVY8, Q8BTX9, Q8R536, Q8VDG5

Diamond homologs: Q28FI7, Q32KX8, Q497C3, Q4V7T1, Q66I74, Q7ZVJ8, Q96S19, Q9DCS2, Q9VLF6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

865 predictions. Top by Δscore:

Variant	Effect	Δscore
16:634797:CCT:C	acceptor_loss	1.0000
16:634798:CTGC:C	acceptor_loss	1.0000
16:635613:T:TA	donor_gain	1.0000
16:634795:TTC:T	acceptor_gain	0.9900
16:634796:TC:T	acceptor_gain	0.9900
16:634797:CC:C	acceptor_gain	0.9900
16:634798:C:CC	acceptor_gain	0.9900
16:634801:C:CT	acceptor_gain	0.9900
16:635279:AC:A	donor_gain	0.9900
16:635279:ACC:A	donor_gain	0.9900
16:635280:CC:C	donor_gain	0.9900
16:635280:CCC:C	donor_gain	0.9900
16:636008:AT:A	donor_gain	0.9900
16:636009:T:TA	donor_gain	0.9900
16:636089:CGCA:C	donor_loss	0.9900
16:636091:CA:C	donor_loss	0.9900
16:636092:A:C	donor_loss	0.9900
16:636093:CCTG:C	donor_loss	0.9900
16:634717:ACCAT:A	donor_gain	0.9800
16:634718:CCATC:C	donor_gain	0.9800
16:634793:GGTTC:G	acceptor_gain	0.9800
16:634794:GTTC:G	acceptor_gain	0.9800
16:634802:A:T	acceptor_gain	0.9800
16:634807:G:GC	acceptor_gain	0.9800
16:634952:TAGGG:T	acceptor_gain	0.9800
16:635276:CTCA:C	donor_loss	0.9800
16:635277:T:TA	donor_loss	0.9800
16:635278:C:CC	donor_loss	0.9800
16:635340:CCTGG:C	acceptor_gain	0.9800
16:635715:T:TA	donor_gain	0.9800

AlphaMissense

1319 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:636131:A:G	W54R	0.990
16:636131:A:T	W54R	0.990
16:635630:G:C	S114R	0.986
16:635630:G:T	S114R	0.986
16:635632:T:G	S114R	0.986
16:635645:G:C	N109K	0.985
16:635645:G:T	N109K	0.985
16:634620:A:G	C198R	0.981
16:634610:A:G	F201S	0.980
16:635282:C:T	G140E	0.973
16:636129:C:A	W54C	0.973
16:636129:C:G	W54C	0.973
16:634918:G:C	N153K	0.972
16:634918:G:T	N153K	0.972
16:634787:A:G	W167R	0.971
16:634787:A:T	W167R	0.971
16:635651:G:C	C107W	0.971
16:634909:A:C	F156L	0.968
16:634909:A:T	F156L	0.968
16:634911:A:G	F156L	0.968
16:634780:A:T	L169H	0.966
16:636130:C:G	W54S	0.966
16:636175:C:T	G39D	0.966
16:634898:A:T	L160H	0.965
16:635283:C:A	G140W	0.965
16:635283:C:G	G140R	0.965
16:635283:C:T	G140R	0.965
16:635646:T:A	N109I	0.965
16:636122:A:G	S57P	0.965
16:634609:G:C	F201L	0.964

dbSNP variants (sampled 300 via entrez): RS1000286847 (16:635667 A>C), RS1000384641 (16:636112 T>C), RS1000651143 (16:636841 A>G,T), RS1000725409 (16:635136 G>C), RS1001470645 (16:636730 A>C,G,T), RS1001884005 (16:636751 T>C,G), RS1002149080 (16:636789 C>T), RS1004320906 (16:635589 C>A,T), RS1005423981 (16:634423 C>G,T), RS1006694755 (16:638229 G>A), RS1006727264 (16:638061 C>T), RS1007382594 (16:634193 G>A), RS1008249136 (16:634892 C>T), RS1008512638 (16:635168 C>A,T), RS1008697082 (16:636558 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003901_8	Cognitive decline (age-related)	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
Benzo(a)pyrene	decreases expression, increases methylation	2
Valproic Acid	affects expression, increases methylation	2
aristolochic acid I	decreases expression	1
arsenite	affects binding, increases reaction	1
perfluorooctane sulfonic acid	increases expression	1
K 7174	decreases expression	1
jinfukang	increases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Vorinostat	increases expression	1
Arsenic	increases abundance, affects cotreatment, decreases expression	1
Cisplatin	increases expression, affects cotreatment	1
Dimethyl Sulfoxide	affects expression	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Lead	affects splicing	1
Methyl Methanesulfonate	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Cyclosporine	decreases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.