METTL8

Summary

METTL8 (methyltransferase 8, tRNA N3-cytidine, HGNC:25856) is a protein-coding gene on chromosome 2q31.1, encoding tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial (Q9H825). Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr).

Enables mRNA methyltransferase activity and tRNA (cytidine-3-)-methyltransferase activity. Involved in RNA metabolic process and positive regulation of mitochondrial translation. Is active in mitochondrial matrix.

Source: NCBI Gene 79828 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 71 total — 1 pathogenic
• MANE Select transcript: NM_001321154

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25856
Approved symbol	METTL8
Name	methyltransferase 8, tRNA N3-cytidine
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ13984, TIP
Ensembl gene	ENSG00000123600
Ensembl biotype	protein_coding
OMIM	609525
Entrez	79828

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 16 protein_coding, 5 protein_coding_CDS_not_defined, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000375258, ENST00000392599, ENST00000392604, ENST00000438609, ENST00000442541, ENST00000442778, ENST00000447486, ENST00000453846, ENST00000460188, ENST00000460539, ENST00000462821, ENST00000463392, ENST00000464491, ENST00000470773, ENST00000477130, ENST00000483284, ENST00000612742, ENST00000907421, ENST00000907422, ENST00000907423, ENST00000907424, ENST00000907425, ENST00000925840, ENST00000925841, ENST00000963895, ENST00000963896

RefSeq mRNA: 10 — MANE Select: NM_001321154 NM_001321154, NM_001321155, NM_001321156, NM_001321157, NM_001321158, NM_001321159, NM_001321160, NM_001321161, NM_001321162, NM_024770

CCDS: CCDS2242, CCDS82531, CCDS82532

Canonical transcript exons

ENST00000375258 — 10 exons

Exon	Start	End
ENSE00001512477	171433883	171433990
ENSE00003462934	171339184	171339554
ENSE00003475551	171337453	171337502
ENSE00003495623	171392043	171392197
ENSE00003585920	171331804	171331867
ENSE00003597011	171360422	171360513
ENSE00003598130	171330559	171330698
ENSE00003625197	171325841	171325906
ENSE00003626485	171326042	171326148
ENSE00003917095	171315746	171324362

Expression profiles

Bgee: expression breadth ubiquitous, 263 present calls, max score 91.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.3209 / max 201.2012, expressed in 1789 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31777	7.2051	1693
31778	4.5505	1659
31776	0.5654	65

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.47	gold quality
buccal mucosa cell	CL:0002336	89.14	gold quality
calcaneal tendon	UBERON:0003701	89.01	gold quality
sperm	CL:0000019	86.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.85	gold quality
penis	UBERON:0000989	85.33	gold quality
tendon	UBERON:0000043	84.86	gold quality
adrenal tissue	UBERON:0018303	84.07	gold quality
nipple	UBERON:0002030	84.06	gold quality
colonic epithelium	UBERON:0000397	83.90	gold quality
male germ cell	CL:0000015	83.69	gold quality
sural nerve	UBERON:0015488	83.25	gold quality
oral cavity	UBERON:0000167	83.13	gold quality
rectum	UBERON:0001052	82.99	gold quality
skin of hip	UBERON:0001554	82.73	gold quality
superficial temporal artery	UBERON:0001614	82.67	gold quality
medial globus pallidus	UBERON:0002477	82.61	gold quality
esophagus mucosa	UBERON:0002469	82.45	gold quality
mammalian vulva	UBERON:0000997	82.29	gold quality
esophagus	UBERON:0001043	81.87	gold quality
lymph node	UBERON:0000029	81.58	gold quality
ventricular zone	UBERON:0003053	81.44	gold quality
muscle layer of sigmoid colon	UBERON:0035805	81.43	gold quality
corpus callosum	UBERON:0002336	81.39	gold quality
esophagus squamous epithelium	UBERON:0006920	81.30	gold quality
globus pallidus	UBERON:0001875	81.15	gold quality
skin of abdomen	UBERON:0001416	81.10	gold quality
skin of leg	UBERON:0001511	81.10	gold quality
lower esophagus	UBERON:0013473	80.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	80.93	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-46	yes	14.11
E-ANND-3	yes	6.08

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

279 targeting METTL8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-507	99.97	70.11	1915

Literature-anchored findings (GeneRIF, showing 5)

• Data, including data from studies using mutant/knockout mice and cell lines from such mice, suggest that METTL2 and METTL6 (but not METTL8) contribute to post-transcriptional methylation of cytidine (formation of 3-methylcytidine) in tRNA; METTL2 methylates tRNA(Thr) and tRNA(Arg); METTL6 interacts with seryl-tRNA synthetase and methylates tRNA(Ser); METTL8 catalyzes post-transcriptional methylation of cytidine in mRNA. (PMID:28655767)
• The RNA methyltransferase METTL8 installs m(3)C32 in mitochondrial tRNAs(Thr/Ser(UCN)) to optimise tRNA structure and mitochondrial translation. (PMID:35017528)
• Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs. (PMID:35247384)
• Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8. (PMID:35357504)
• METTL8 links mt-tRNA m[3]C modification to the HIF1alpha/RTK/Akt axis to sustain GBM stemness and tumorigenicity. (PMID:38744809)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mettl8	ENSDARG00000017359
mus_musculus	Mettl8	ENSMUSG00000041975
rattus_norvegicus	Mettl8	ENSRNOG00000009382

Paralogs (3): METTL2A (ENSG00000087995), METTL2B (ENSG00000165055), METTL6 (ENSG00000206562)

Protein

Protein identifiers

tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial — Q9H825 (reviewed: Q9H825)

Alternative names: Methyltransferase-like protein 8, mRNA N(3)-methylcytidine methyltransferase METTL8

All UniProt accessions (7): B3KW44, B5ME25, C9J3F1, C9J6U8, C9JE69, Q9H825, H7C2P8

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain. N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite. May also mediate N(3)-methylcytidine modification of mRNAs. The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo.

Subunit / interactions. Interacts with EP300.

Subcellular location. Mitochondrion.

Similarity. Belongs to the methyltransferase superfamily. METL family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H825-1	1	yes
Q9H825-2	2

RefSeq proteins (10): NP_001308083, NP_001308084, NP_001308085, NP_001308086, NP_001308087, NP_001308088, NP_001308089, NP_001308090, NP_001308091, NP_079046 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026113	METTL2/6/8-like	Family
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily
IPR041698	Methyltransf_25	Domain

Pfam: PF13649

Catalyzed reactions (Rhea), 3 shown:

• cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+) (RHEA:50956)
• cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine + H(+) (RHEA:50960)
• a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H(+) (RHEA:60916)

UniProt features (15 total): binding site 5, mutagenesis site 4, transit peptide 1, chain 1, splice variant 1, region of interest 1, compositionally biased region 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H825-F1	73.00	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 89; 93; 204; 230; 256

Post-translational modifications (1): 80

Mutagenesis-validated functional residues (4):

Position	Phenotype
4	partial relocalization to the cytoplasm; when associated with q-9.
9	partial relocalization to the cytoplasm; when associated with q-4.
80	abolished sumoylation.
230	abolished n(3)-methylcytidine methyltransferase activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 246 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GCANCTGNY_MYOD_Q6, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_TRNA_METABOLIC_PROCESS, GOBP_MITOCHONDRIAL_TRANSLATION, CAGCTG_AP4_Q5, GOBP_RNA_METHYLATION, AACWWCAANK_UNKNOWN, GOBP_TRANSLATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_RNA_MODIFICATION, HUTTMANN_B_CLL_POOR_SURVIVAL_DN, TGIF_01, GOBP_MITOCHONDRIAL_RNA_PROCESSING, GOBP_TRNA_METHYLATION

GO Biological Process (9): mRNA metabolic process (GO:0016071), positive regulation of mitochondrial translation (GO:0070131), mitochondrial tRNA modification (GO:0070900), tRNA C3-cytosine methylation (GO:0106217), chromatin remodeling (GO:0006338), skeletal muscle tissue development (GO:0007519), tRNA processing (GO:0008033), methylation (GO:0032259), fat cell differentiation (GO:0045444)

GO Molecular Function (7): mRNA methyltransferase activity (GO:0008174), tRNA (cytidine-N3)-methyltransferase activity (GO:0052735), histone acetyltransferase activity (GO:0004402), methyltransferase activity (GO:0008168), RNA methyltransferase activity (GO:0008173), S-adenosylmethionine-dependent methyltransferase activity (GO:0008757), transferase activity (GO:0016740)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	2
methyltransferase activity	2
intracellular membrane-bounded organelle	2
RNA metabolic process	1
mitochondrial translation	1
positive regulation of translation	1
regulation of mitochondrial translation	1
tRNA modification	1
mitochondrial tRNA processing	1
mitochondrial RNA modification	1
tRNA methylation	1
chromatin organization	1
striated muscle tissue development	1
skeletal muscle organ development	1
RNA processing	1
tRNA metabolic process	1
metabolic process	1
cell differentiation	1
RNA methyltransferase activity	1
S-adenosylmethionine-dependent methyltransferase activity	1
tRNA (cytidine) methyltransferase activity	1
protein-lysine-acetyltransferase activity	1
histone modifying activity	1
transferase activity, transferring one-carbon groups	1
catalytic activity, acting on RNA	1
catalytic activity	1
cytoplasm	1
intracellular organelle lumen	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
METTL8	TAX1BP3	O14907	876
METTL8	METTL25	Q8N6Q8	783
METTL8	TLCD4	Q96MV1	647
METTL8	GIPC1	O14908	626
METTL8	METTL9	Q9H1A3	625
METTL8	HEXIM2	Q96MH2	616
METTL8	TMT1B	Q6UX53	612
METTL8	TRMT10B	Q6PF06	590
METTL8	EEF1AKMT2	Q5JPI9	577
METTL8	METTL13	Q8N6R0	556
METTL8	METTL5	Q9NRN9	534
METTL8	SOCS1	O15524	530
METTL8	GFI1B	Q5VTD9	523
METTL8	TRMT10A	Q8TBZ6	518
METTL8	SARS1	P49591	506

IntAct

10 interactions, top by confidence:

A	B	Type	Score
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
TRIP13	INTS11	psi-mi:“MI:0914”(association)	0.550
DCAF8	TCP1	psi-mi:“MI:0914”(association)	0.530
CD6	CIBAR1	psi-mi:“MI:0914”(association)	0.350
CD44	TCAF2	psi-mi:“MI:0914”(association)	0.350
SDC4	FGF2	psi-mi:“MI:0914”(association)	0.350
SDC2	ELAPOR2	psi-mi:“MI:0914”(association)	0.350
UBR4	METTL15	psi-mi:“MI:0914”(association)	0.350
DSCR9	METTL8	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A1L1P7, A6ZND9, A6ZSH0, B0BN56, B3LIY9, B3LPE4, B5VQB0, C5DKM2, D3ZYW7, F4I9Q5, O14320, O35658, O35796, O35943, O49196, P37841, P42797, P42844, P49727, P51132, P51133, P51135, P82928, Q01607, Q04907, Q05B87, Q07021, Q08230, Q09759, Q0IH40, Q16595, Q1JPN0, Q2KI49, Q3T0B6, Q5REH5, Q84WZ8, Q8HXX9, Q8N5N7, Q8VZE7, Q94JS0

Diamond homologs: A2AUU0, A8KBL7, Q0P5B2, Q5M8E6, Q5ZHP8, Q6P1Q9, Q86BS6, Q8BMK1, Q96IZ6, Q9H825, G0REX6, O74386, Q08641, Q5ATG8, Q5RDV8, Q6AXU8, Q8BVH9, Q8T199, Q8TCB7, Q9P7L6, A0A0C6E0I7, A1JRM2, A4TJK8, A7FID3, A9QYY1, B1JLL8, B2K316, Q1C823, Q1CJH3, Q66AU7, Q7CIB7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	47
Likely benign	6
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3247166	NC_000002.11:g.(?172291088)(172291716_?)del	Pathogenic

SpliceAI

2128 predictions. Top by Δscore:

Variant	Effect	Δscore
2:171326040:AC:A	donor_gain	1.0000
2:171326041:CC:C	donor_gain	1.0000
2:171337451:A:AC	donor_gain	1.0000
2:171337452:CT:C	donor_gain	1.0000
2:171339550:CTTAA:C	acceptor_gain	1.0000
2:171326068:T:C	donor_gain	0.9900
2:171326148:CCTT:C	acceptor_gain	0.9900
2:171337451:ACT:A	donor_gain	0.9900
2:171337452:CTC:C	donor_gain	0.9900
2:171339209:C:CT	donor_gain	0.9900
2:171339210:T:TT	donor_gain	0.9900
2:171339551:TTAA:T	acceptor_gain	0.9900
2:171339552:TAA:T	acceptor_gain	0.9900
2:171339554:AC:A	acceptor_loss	0.9900
2:171339555:C:CA	acceptor_loss	0.9900
2:171339555:C:CC	acceptor_gain	0.9900
2:171339556:T:A	acceptor_loss	0.9900
2:171434699:GCCAG:G	donor_loss	0.9900
2:171434700:CCAGG:C	donor_loss	0.9900
2:171434701:CAGG:C	donor_loss	0.9900
2:171434702:AG:A	donor_loss	0.9900
2:171434703:GGT:G	donor_loss	0.9900
2:171434705:T:A	donor_loss	0.9900
2:171326037:ATTAC:A	donor_gain	0.9800
2:171327983:T:A	donor_gain	0.9800
2:171330694:TGTGA:T	acceptor_gain	0.9800
2:171330699:C:CC	acceptor_gain	0.9800
2:171339180:ATAC:A	donor_loss	0.9800
2:171339182:ACCT:A	donor_loss	0.9800
2:171339183:C:A	donor_loss	0.9800

AlphaMissense

2505 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:171337479:A:C	S210R	0.996
2:171337479:A:T	S210R	0.996
2:171337481:T:G	S210R	0.996
2:171339514:A:C	F92L	0.996
2:171339514:A:T	F92L	0.996
2:171339516:A:G	F92L	0.996
2:171330585:A:C	F278L	0.995
2:171330585:A:T	F278L	0.995
2:171330587:A:G	F278L	0.995
2:171339523:C:A	W89C	0.995
2:171339523:C:G	W89C	0.995
2:171339457:A:C	F111L	0.994
2:171339457:A:T	F111L	0.994
2:171339459:A:G	F111L	0.994
2:171331840:A:C	C228W	0.993
2:171339490:A:C	F100L	0.993
2:171339490:A:T	F100L	0.993
2:171339492:A:G	F100L	0.993
2:171360513:C:A	W48C	0.993
2:171360513:C:G	W48C	0.993
2:171339474:A:G	W106R	0.992
2:171339474:A:T	W106R	0.992
2:171339480:G:T	R104S	0.992
2:171392044:A:G	W48R	0.992
2:171392044:A:T	W48R	0.992
2:171339525:A:G	W89R	0.991
2:171339525:A:T	W89R	0.991
2:171337486:C:A	G208V	0.990
2:171339188:A:G	L201P	0.990
2:171330660:A:C	F253L	0.989

dbSNP variants (sampled 300 via entrez): RS1000012212 (2:171324413 G>A), RS1000024398 (2:171396563 C>T), RS1000030473 (2:171421255 C>T), RS1000033566 (2:171356775 A>G), RS1000075721 (2:171394088 C>T), RS1000124294 (2:171421806 G>A), RS1000143131 (2:171349247 G>A), RS1000220905 (2:171331134 C>G,T), RS1000225739 (2:171392416 T>C), RS1000280733 (2:171375486 A>C), RS1000325850 (2:171369428 T>C), RS1000380390 (2:171324683 C>T), RS1000408160 (2:171355682 C>A), RS1000411417 (2:171399523 T>C), RS1000440256 (2:171318089 G>A)

Disease associations

OMIM: gene MIM:609525 | disease phenotypes: MIM:241080

GenCC curated gene-disease

Mondo (1): Woodhouse-Sakati syndrome (MONDO:0009419)

Orphanet (1): Woodhouse-Sakati syndrome (Orphanet:3464)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001530_3	Hippocampal atrophy	5.000000e-06
GCST002783_317	Body mass index	3.000000e-06
GCST012227_1234	Hip circumference adjusted for BMI	4.000000e-10
GCST90000025_825	Appendicular lean mass	2.000000e-11
GCST90020028_740	Hip circumference adjusted for BMI	2.000000e-08
GCST90020028_741	Hip circumference adjusted for BMI	3.000000e-09
GCST90020028_742	Hip circumference adjusted for BMI	8.000000e-13
GCST90020028_743	Hip circumference adjusted for BMI	4.000000e-08
GCST90020028_744	Hip circumference adjusted for BMI	5.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005039	hippocampal atrophy
EFO:0004340	body mass index
EFO:0008039	BMI-adjusted hip circumference
EFO:0004980	appendicular lean mass

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C536742	Woodhouse Sakati syndrome (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	4
trichostatin A	affects cotreatment, increases expression	3
entinostat	increases expression, affects cotreatment	2
Benzo(a)pyrene	affects methylation, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tretinoin	decreases expression	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
arsenite	affects binding, increases reaction	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	increases expression, affects cotreatment	1
jinfukang	affects cotreatment, increases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Calcitriol	decreases expression, affects cotreatment	1
Cisplatin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression	1
Formaldehyde	decreases expression	1
Gallic Acid	increases expression	1
Methapyrilene	increases methylation	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SY13	HAP1 METTL8 (-) 1	Cancer cell line	Male
CVCL_SY14	HAP1 METTL8 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT05522374	Not specified	RECRUITING	TIRCON International NBIA Registry