MFSD12

Summary

MFSD12 (major facilitator superfamily domain containing 12, HGNC:28299) is a protein-coding gene on chromosome 19p13.3, encoding Major facilitator superfamily domain-containing protein 12 (Q6NUT3). Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation.

Enables cysteine transmembrane transporter activity. Involved in cysteine transmembrane transport; pigment metabolic process involved in pigmentation; and regulation of melanin biosynthetic process. Located in lysosome and melanosome. Part of late endosome.

Source: NCBI Gene 126321 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 44 total
• MANE Select transcript: NM_174983

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28299
Approved symbol	MFSD12
Name	major facilitator superfamily domain containing 12
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC20700, PP3501, SLC59B1
Ensembl gene	ENSG00000161091
Ensembl biotype	protein_coding
OMIM	617745
Entrez	126321

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 8 protein_coding, 3 nonsense_mediated_decay, 2 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000355415, ENST00000398558, ENST00000585788, ENST00000585814, ENST00000586402, ENST00000588626, ENST00000588918, ENST00000589063, ENST00000589157, ENST00000589995, ENST00000591878, ENST00000592652, ENST00000615073, ENST00000913269, ENST00000951867

RefSeq mRNA: 2 — MANE Select: NM_174983 NM_001287529, NM_174983

CCDS: CCDS42465, CCDS74256

Canonical transcript exons

ENST00000355415 — 10 exons

Exon	Start	End
ENSE00001115268	3546255	3546425
ENSE00001115271	3547272	3547364
ENSE00001148437	3546074	3546168
ENSE00001402446	3557106	3557586
ENSE00001407707	3544199	3544732
ENSE00002247760	3544809	3544939
ENSE00003459115	3548123	3548267
ENSE00003515695	3550984	3551194
ENSE00003619112	3547455	3547547
ENSE00003620104	3547848	3548030

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 96.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 67.3401 / max 2705.6961, expressed in 1817 samples.

FANTOM5 promoters (22 alternative TSS)

Promoter ID	TPM avg	Samples expressed
178303	56.9738	1813
178302	3.7720	178
178304	2.9052	1259
178317	1.0760	482
178298	0.6511	255
178299	0.4423	156
178315	0.4118	58
178307	0.2608	64
178294	0.1421	55
178314	0.1256	43

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	96.92	gold quality
metanephros cortex	UBERON:0010533	96.63	gold quality
right uterine tube	UBERON:0001302	96.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.14	gold quality
cerebellar hemisphere	UBERON:0002245	95.41	gold quality
granulocyte	CL:0000094	95.37	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.27	gold quality
cerebellar cortex	UBERON:0002129	95.17	gold quality
adenohypophysis	UBERON:0002196	94.67	gold quality
body of pancreas	UBERON:0001150	94.65	gold quality
right lobe of thyroid gland	UBERON:0001119	94.37	gold quality
right frontal lobe	UBERON:0002810	94.28	gold quality
left lobe of thyroid gland	UBERON:0001120	93.94	gold quality
monocyte	CL:0000576	93.87	gold quality
mononuclear cell	CL:0000842	93.69	gold quality
leukocyte	CL:0000738	93.56	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.56	gold quality
tibial nerve	UBERON:0001323	93.30	gold quality
lower esophagus mucosa	UBERON:0035834	93.20	gold quality
skin of leg	UBERON:0001511	93.06	gold quality
minor salivary gland	UBERON:0001830	92.94	gold quality
pituitary gland	UBERON:0000007	92.82	gold quality
left adrenal gland cortex	UBERON:0035825	92.75	gold quality
spinal cord	UBERON:0002240	92.64	gold quality
thyroid gland	UBERON:0002046	92.56	gold quality
spleen	UBERON:0002106	92.46	gold quality
right coronary artery	UBERON:0001625	92.37	gold quality
skin of abdomen	UBERON:0001416	92.35	gold quality
body of stomach	UBERON:0001161	92.32	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.32	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	18.25
E-ANND-3	yes	7.50
E-CURD-112	yes	3.83

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting MFSD12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-423-5P	98.69	67.48	1522
HSA-MIR-3184-5P	98.56	67.13	1491
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-5194	96.77	63.91	1021
HSA-MIR-6738-5P	96.33	63.61	815
HSA-MIR-1266-3P	96.23	66.36	778
HSA-MIR-6734-5P	95.70	65.56	950
HSA-MIR-1914-3P	95.07	63.37	762

Literature-anchored findings (GeneRIF, showing 4)

• pp3501 inhibited the proliferation of SH-SY5Y cells, arrested the cell cycle at G1 phase, and sensitized the SH-SY5Y cells to sodium butyrate treatment. (PMID:22441875)
• Elevated MFSD12 expression promotes melanoma cell proliferation, and MFSD12 is a valuable prognostic biomarker and promising therapeutic target in melanoma. (PMID:30385854)
• MFSD12 mediates the import of cysteine into melanosomes and lysosomes. (PMID:33208952)
• Major Facilitator Superfamily Domain Containing 12 Is Overexpressed in Lung Cancer and Exhibits an Oncogenic Role in Lung Adenocarcinoma Cells. (PMID:38687351)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mfsd12a	ENSDARG00000061908
mus_musculus	Mfsd12	ENSMUSG00000034854
rattus_norvegicus	Mfsd12	ENSRNOG00000039858
caenorhabditis_elegans		WBGENE00017530

Paralogs (2): MFSD2A (ENSG00000168389), MFSD2B (ENSG00000205639)

Protein

Protein identifiers

Major facilitator superfamily domain-containing protein 12 — Q6NUT3 (reviewed: Q6NUT3)

All UniProt accessions (8): Q6NUT3, A0A087WU85, A0A0A0MS91, K7EJS5, K7EKU1, K7ENE1, K7EQ22, K7ERJ8

UniProt curated annotations — full annotation on UniProt →

Function. Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis.

Subcellular location. Melanosome membrane. Lysosome membrane.

Tissue specificity. Widely expressed, with high expression in primary melanocytes.

Post-translational modifications. Phosphorylation at Thr-254 by MTOR via mTORC1 pathway promotes cysteine transport in lysosomes, thereby regulating lysosomal cysteine and cystine storage and redox homeostasis.

Polymorphism. Genetic variants in MFSD12 cause skin pigmentation variation. Skin pigmentation is among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. His-192 is commonly found in East Asians and Native Americans only, and significantly correlates with lower solar radiation intensity in East Asia.

Similarity. Belongs to the major facilitator superfamily.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6NUT3-1	1	yes
Q6NUT3-2	2
Q6NUT3-3	3
Q6NUT3-4	4

RefSeq proteins (2): NP_001274458, NP_778148* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR039672	MFS_2	Family

Pfam: PF13347

Catalyzed reactions (Rhea), 1 shown:

• L-cysteine(in) = L-cysteine(out) (RHEA:29655)

UniProt features (43 total): topological domain 12, transmembrane region 12, mutagenesis site 7, sequence variant 5, splice variant 3, modified residue 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6NUT3-F1	84.77	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 254

Mutagenesis-validated functional residues (7):

Position	Phenotype
13	does not affect phosphorylation by mtor.
73	does not affect phosphorylation by mtor.
113	does not affect phosphorylation by mtor.
122	does not affect phosphorylation by mtor.
254	abolished phosphorylation by mtor; dominant-negative inhibitor of cysteine transporter activity.
254	mimics phosphorylation; enhanced cysteine and cystine storage in lysosomes.
256–257	reduced localization to lysosomes and redirection to the cell membrane.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 172 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP, GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_TRANSPORT, GOBP_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS, GOCC_VACUOLAR_MEMBRANE, GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_PIGMENTATION, GOBP_AMINO_ACID_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_SULFUR_COMPOUND_TRANSPORT, GOBP_PIGMENT_METABOLIC_PROCESS, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, GOBP_ORGANIC_CATION_TRANSPORT, GOBP_PIGMENT_BIOSYNTHETIC_PROCESS

GO Biological Process (8): carbohydrate transport (GO:0008643), melanin biosynthetic process (GO:0042438), pigment metabolic process involved in pigmentation (GO:0043474), regulation of melanin biosynthetic process (GO:0048021), negative regulation of melanin biosynthetic process (GO:0048022), L-cysteine transmembrane transport (GO:1903712), amino acid transport (GO:0006865), transmembrane transport (GO:0055085)

GO Molecular Function (3): symporter activity (GO:0015293), L-cysteine transmembrane transporter activity (GO:0033229), protein binding (GO:0005515)

GO Cellular Component (7): lysosome (GO:0005764), lysosomal membrane (GO:0005765), late endosome (GO:0005770), plasma membrane (GO:0005886), melanosome membrane (GO:0033162), melanosome (GO:0042470), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
melanin biosynthetic process	2
melanin metabolic process	1
secondary metabolite biosynthetic process	1
pigment biosynthetic process	1
phenol-containing compound biosynthetic process	1
pigment metabolic process	1
pigmentation	1
regulation of secondary metabolite biosynthetic process	1
regulation of melanin biosynthetic process	1
negative regulation of secondary metabolite biosynthetic process	1
L-cysteine transport	1
L-alpha-amino acid transmembrane transport	1
cellular process	1
secondary active transmembrane transporter activity	1
sulfur amino acid transmembrane transporter activity	1
neutral L-amino acid transmembrane transporter activity	1
L-amino acid transmembrane transporter activity	1
L-cysteine transmembrane transport	1
binding	1
lytic vacuole	1
lysosome	1
lytic vacuole membrane	1
endosome	1
membrane	1
cell periphery	1
melanosome	1
chitosome	1
pigment granule membrane	1
pigment granule	1
cellular anatomical structure	1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MFSD12	SLC45A2	Q9UMX9	689
MFSD12	SLC67A2	Q8NBP5	639
MFSD12	MFSD6L	Q8IWD5	625
MFSD12	MFSD11	O43934	624
MFSD12	SLC24A5	Q71RS6	609
MFSD12	SLC68A1	Q14CX5	606
MFSD12	MFSD6	Q6ZSS7	578
MFSD12	SLC75A1	Q14728	537
MFSD12	UNC93A	Q86WB7	530
MFSD12	OCA2	Q04671	527
MFSD12	MFSD8	Q8NHS3	515
MFSD12	SLC61A1	Q6N075	511
MFSD12	TMEM132E	Q6IEE7	498
MFSD12	TLCD3A	Q8TBR7	493
MFSD12	TPCN2	Q8NHX9	492

IntAct

26 interactions, top by confidence:

A	B	Type	Score
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
SLC39A4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
MFSD12	ADRB2	psi-mi:“MI:0915”(physical association)	0.370
Nrip3	ILVBL	psi-mi:“MI:0914”(association)	0.350
Npc1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
TSPAN15	TMEM223	psi-mi:“MI:0914”(association)	0.350
BSCL2	TMEM223	psi-mi:“MI:0914”(association)	0.350
CRELD1	TMEM223	psi-mi:“MI:0914”(association)	0.350
GPR17	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TSPAN31	TMEM120B	psi-mi:“MI:0914”(association)	0.350
OPRL1	METTL15	psi-mi:“MI:0914”(association)	0.350
SCN4A	C2CD4B	psi-mi:“MI:0914”(association)	0.350
SLC22A4	RTL8C	psi-mi:“MI:0914”(association)	0.350
TMEM169	GPR89A	psi-mi:“MI:0914”(association)	0.350
SLC5A6	SLC31A1	psi-mi:“MI:0914”(association)	0.350
SLC26A6	SLC25A17	psi-mi:“MI:0914”(association)	0.350
PMEL	MAN1A2	psi-mi:“MI:0914”(association)	0.350
SYPL2	TSPAN15	psi-mi:“MI:0914”(association)	0.350
UPK1A	MFSD12	psi-mi:“MI:0914”(association)	0.350
SLCO4C1	SLC9A1	psi-mi:“MI:0914”(association)	0.350
LDLRAD1	ZNF316	psi-mi:“MI:0914”(association)	0.350
MFSD12	SNAP23	psi-mi:“MI:0914”(association)	0.350

BioGRID (92): MFSD12 (Affinity Capture-MS), MFSD12 (Synthetic Growth Defect), MFSD12 (Affinity Capture-MS), MFSD12 (Affinity Capture-MS), MFSD12 (Affinity Capture-MS), MFSD12 (Affinity Capture-MS), MFSD12 (Affinity Capture-MS), MFSD12 (Affinity Capture-MS), MFSD12 (Two-hybrid), MFSD12 (Two-hybrid), SSMEM1 (Two-hybrid), MFSD12 (Two-hybrid), MFSD12 (Affinity Capture-MS), MFSD12 (Affinity Capture-RNA), MFSD12 (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q2HW92, A6NDV4, A6NFX1, A6QLK4, B1AWJ5, F1NCD6, F1NJ67, F1PZV2, O35308, O35595, O70461, O95907, Q08DX7, Q0IHM1, Q0P5C0, Q0P5M9, Q13286, Q14728, Q29611, Q2YDU8, Q3T9M1, Q3U481, Q501I9, Q5R8G5, Q5R9A1, Q5U419, Q60HH0, Q61124, Q66H95, Q6NUT3, Q6UXD7, Q6ZMD2, Q7RTT9, Q8BFQ6, Q8CE47, Q8NA29, Q8R0G7, Q8R139, Q8TB61, Q8VCW4

Diamond homologs: A0A3Q2HW92, F1PZV2, Q3U481, Q6NUT3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 37 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SLC-mediated transmembrane transport	6	16.9×	9e-05
Transport of small molecules	6	7.2×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

44 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	10
Likely benign	5
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

2316 predictions. Top by Δscore:

Variant	Effect	Δscore
19:3543233:A:AG	acceptor_gain	1.0000
19:3543233:AGC:A	acceptor_gain	1.0000
19:3543234:G:GG	acceptor_gain	1.0000
19:3543234:GC:G	acceptor_gain	1.0000
19:3543234:GCG:G	acceptor_gain	1.0000
19:3543234:GCGAT:G	acceptor_gain	1.0000
19:3543252:T:TA	acceptor_gain	1.0000
19:3543453:G:GG	donor_gain	1.0000
19:3546068:ACTC:A	donor_loss	1.0000
19:3546069:CTCA:C	donor_loss	1.0000
19:3546070:TCA:T	donor_loss	1.0000
19:3546072:A:AC	donor_gain	1.0000
19:3546072:ACG:A	donor_loss	1.0000
19:3546072:ACGGG:A	donor_gain	1.0000
19:3546073:C:CT	donor_gain	1.0000
19:3546073:CG:C	donor_gain	1.0000
19:3546073:CGG:C	donor_gain	1.0000
19:3546073:CGGG:C	donor_gain	1.0000
19:3546073:CGGGC:C	donor_gain	1.0000
19:3546164:CTGTT:C	acceptor_gain	1.0000
19:3546165:TGTT:T	acceptor_gain	1.0000
19:3546166:GTT:G	acceptor_gain	1.0000
19:3546167:TT:T	acceptor_gain	1.0000
19:3546169:C:CC	acceptor_gain	1.0000
19:3546170:T:G	acceptor_loss	1.0000
19:3546171:G:C	acceptor_gain	1.0000
19:3546249:CCCTA:C	donor_loss	1.0000
19:3546250:CCTAC:C	donor_loss	1.0000
19:3546252:TAC:T	donor_loss	1.0000
19:3546253:A:AC	donor_gain	1.0000

AlphaMissense

3052 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:3550984:C:A	R170M	0.998
19:3551069:A:G	W142R	0.998
19:3551069:A:T	W142R	0.998
19:3546136:G:C	S409R	0.997
19:3546136:G:T	S409R	0.997
19:3546138:T:G	S409R	0.997
19:3557284:G:C	F40L	0.997
19:3557284:G:T	F40L	0.997
19:3557286:A:G	F40L	0.997
19:3557308:G:C	N32K	0.997
19:3557308:G:T	N32K	0.997
19:3547509:G:C	N292K	0.996
19:3547509:G:T	N292K	0.996
19:3547522:C:A	R288M	0.996
19:3548247:G:T	A177D	0.996
19:3550996:A:G	L166P	0.996
19:3551044:A:G	L150P	0.996
19:3551194:C:T	G100D	0.996
19:3557106:C:G	G100R	0.996
19:3557211:C:G	G65R	0.996
19:3557289:A:G	W39R	0.996
19:3557289:A:T	W39R	0.996
19:3557306:T:A	D33V	0.996
19:3557307:C:G	D33H	0.996
19:3557322:C:G	G28R	0.996
19:3546124:C:A	K413N	0.995
19:3546124:C:G	K413N	0.995
19:3546271:A:G	L393P	0.995
19:3547326:G:C	S323R	0.995
19:3547326:G:T	S323R	0.995

dbSNP variants (sampled 300 via entrez): RS1000194338 (19:3555253 C>T), RS1000536816 (19:3546863 T>C), RS1000618834 (19:3553326 G>A), RS1000803191 (19:3554195 G>A,T), RS1000861814 (19:3539048 C>A,G,T), RS1000865743 (19:3552763 A>G), RS1000999840 (19:3544553 TGCCCTCACCC>T), RS1001138191 (19:3544429 A>G), RS1001146108 (19:3557417 C>T), RS1001295935 (19:3541534 G>A), RS1001367325 (19:3542627 C>T), RS1001473630 (19:3551639 C>T), RS1001481416 (19:3542496 C>CA), RS1001506248 (19:3554462 A>G), RS1001572870 (19:3545885 T>G)

Disease associations

OMIM: gene MIM:617745 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST007452_13	Skin pigmentation	2.000000e-10
GCST008516_10	Skin pigmentation (conditioned on rs1426654 and rs35397)	6.000000e-09
GCST008516_3	Skin pigmentation (conditioned on rs1426654 and rs35397)	2.000000e-08
GCST010303_58	Nevus count or cutaneous melanoma	2.000000e-09
GCST010304_9	Cutaneous malignant melanoma	4.000000e-10
GCST90002283_7	Facial pigmentation measurement (UV light)	1.000000e-08
GCST90002284_7	Facial pigmentation measurement (polar light)	2.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004632	nevus count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation	4
Acetaminophen	increases expression	2
Estradiol	affects cotreatment, increases expression	2
Cadmium Chloride	increases abundance, increases expression	2
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	increases expression	1
K 7174	increases expression	1
abrine	increases expression	1
MT19c compound	decreases expression	1
Sunitinib	decreases expression	1
Cadmium	increases abundance, increases expression	1
Cisplatin	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Phthalic Acids	increases methylation	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	increases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	increases expression	1
Acrylamide	decreases expression	1
Volatile Organic Compounds	affects expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4GB	HCT116-MFSD12-KO-c10	Cancer cell line	Male
CVCL_D4GC	HCT116-MFSD12-KO-c9	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.