MGAT3-AS1

Summary

MGAT3-AS1 (MGAT3 antisense RNA 1, HGNC:51356) is a long non-coding RNA gene on chromosome 22q13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51356
Approved symbol	MGAT3-AS1
Name	MGAT3 antisense RNA 1
Location	22q13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TapSAKI
Ensembl gene	ENSG00000227188
Ensembl biotype	lncRNA
Entrez	104502417
RNAcentral	URS00001B3E73 — lncRNA, 498 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000432239

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432239 — 2 exons

Exon	Start	End
ENSE00001692282	39475807	39475939
ENSE00001701305	39476458	39476822

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 96.60.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.60	gold quality
bone marrow cell	CL:0002092	69.59	silver quality
right hemisphere of cerebellum	UBERON:0014890	69.52	gold quality
cerebellum	UBERON:0002037	68.93	gold quality
cerebellar hemisphere	UBERON:0002245	68.90	gold quality
cerebellar cortex	UBERON:0002129	68.83	gold quality
cortical plate	UBERON:0005343	68.40	gold quality
duodenum	UBERON:0002114	67.92	gold quality
ventricular zone	UBERON:0003053	67.25	gold quality
ganglionic eminence	UBERON:0004023	66.20	gold quality
right frontal lobe	UBERON:0002810	64.97	gold quality
anterior cingulate cortex	UBERON:0009835	64.90	gold quality
nucleus accumbens	UBERON:0001882	64.84	gold quality
frontal cortex	UBERON:0001870	64.64	gold quality
prefrontal cortex	UBERON:0000451	64.53	gold quality
cerebral cortex	UBERON:0000956	63.89	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.65	gold quality
bone marrow	UBERON:0002371	63.20	gold quality
brain	UBERON:0000955	63.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.17	gold quality
hypothalamus	UBERON:0001898	62.90	gold quality
corpus callosum	UBERON:0002336	62.64	gold quality
rectum	UBERON:0001052	62.62	gold quality
tonsil	UBERON:0002372	62.25	gold quality
left testis	UBERON:0004533	61.88	gold quality
Ammon’s horn	UBERON:0001954	61.85	gold quality
temporal lobe	UBERON:0001871	61.66	gold quality
amygdala	UBERON:0001876	61.45	gold quality
apex of heart	UBERON:0002098	61.35	gold quality
caudate nucleus	UBERON:0001873	61.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• TapSAKI knockdown increased miR-22 expression, decreased Phosphatase and Tensin Homolog (PTEN), Toll-like Receptor 4 (TLR4) and p-p65 expressions, and inhibited apoptosis protein cleaved-caspase-3 expression, and HK-2 cell apoptosis. (PMID:30666657)
• Endogenous intronic antisense long non-coding RNA, MGAT3-AS1, and kidney transplantation. (PMID:31611608)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.