MGST2

Summary

MGST2 (microsomal glutathione S-transferase 2, HGNC:7063) is a protein-coding gene on chromosome 4q31.1, encoding Microsomal glutathione S-transferase 2 (Q99735). Catalyzes several different glutathione-dependent reactions.

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Source: NCBI Gene 4258 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 33 total
• Druggable target: yes
• MANE Select transcript: NM_002413

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7063
Approved symbol	MGST2
Name	microsomal glutathione S-transferase 2
Location	4q31.1
Locus type	gene with protein product
Status	Approved
Aliases	MGST-II
Ensembl gene	ENSG00000085871
Ensembl biotype	protein_coding
OMIM	601733
Entrez	4258

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000265498, ENST00000502587, ENST00000503816, ENST00000506797, ENST00000515067, ENST00000515137, ENST00000616265, ENST00000899645, ENST00000899646, ENST00000899647, ENST00000899648, ENST00000899649, ENST00000933959, ENST00000971596

RefSeq mRNA: 4 — MANE Select: NM_002413 NM_001204366, NM_001204367, NM_001204368, NM_002413

CCDS: CCDS3749, CCDS56339

Canonical transcript exons

ENST00000265498 — 5 exons

Exon	Start	End
ENSE00001192223	139704016	139704243
ENSE00003492491	139695197	139695267
ENSE00003505860	139703455	139703536
ENSE00003675009	139678543	139678642
ENSE00003847049	139665819	139666077

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 98.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.0556 / max 250.8759, expressed in 1754 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49759	9.2855	1701
49760	5.9816	1461
49766	3.2986	861
49761	0.8637	525
49765	0.7501	377
49764	0.3665	222
49762	0.1911	72
49763	0.1607	71
49767	0.1577	67

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	98.46	gold quality
secondary oocyte	CL:0000655	98.29	gold quality
esophagus mucosa	UBERON:0002469	98.27	gold quality
lower esophagus mucosa	UBERON:0035834	98.24	gold quality
rectum	UBERON:0001052	98.21	gold quality
right lobe of liver	UBERON:0001114	98.12	gold quality
tongue squamous epithelium	UBERON:0006919	97.83	gold quality
oocyte	CL:0000023	97.82	gold quality
esophagus squamous epithelium	UBERON:0006920	97.71	gold quality
gall bladder	UBERON:0002110	97.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	97.61	gold quality
right adrenal gland cortex	UBERON:0035827	97.60	gold quality
right adrenal gland	UBERON:0001233	97.54	gold quality
squamous epithelium	UBERON:0006914	97.44	gold quality
epithelium of esophagus	UBERON:0001976	97.36	gold quality
left adrenal gland	UBERON:0001234	97.27	gold quality
apex of heart	UBERON:0002098	97.20	gold quality
left adrenal gland cortex	UBERON:0035825	97.20	gold quality
cervix squamous epithelium	UBERON:0006922	97.12	gold quality
pharyngeal mucosa	UBERON:0000355	97.10	gold quality
duodenum	UBERON:0002114	97.07	gold quality
adrenal cortex	UBERON:0001235	97.03	gold quality
minor salivary gland	UBERON:0001830	96.96	gold quality
right atrium auricular region	UBERON:0006631	96.94	gold quality
liver	UBERON:0002107	96.93	gold quality
mouth mucosa	UBERON:0003729	96.92	gold quality
adrenal tissue	UBERON:0018303	96.90	gold quality
gingival epithelium	UBERON:0001949	96.83	gold quality
skin of abdomen	UBERON:0001416	96.71	gold quality
adrenal gland	UBERON:0002369	96.67	gold quality

Single-cell (SCXA)

Detected in 15 experiment(s), a significant marker in 14.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	1290.14
E-HCAD-1	yes	218.89
E-MTAB-10287	yes	92.89
E-MTAB-6701	yes	51.23
E-MTAB-8410	yes	46.83
E-GEOD-134144	yes	46.79
E-HCAD-11	yes	45.18
E-CURD-46	yes	27.12
E-ANND-3	yes	16.56
E-HCAD-10	yes	14.83
E-CURD-112	yes	10.79
E-MTAB-9388	yes	10.68
E-MTAB-10553	yes	6.56
E-GEOD-130148	yes	4.82
E-MTAB-6678	no	3.30

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting MGST2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-2276-3P	98.76	67.75	1384
HSA-MIR-10526-3P	97.86	64.97	1342
HSA-MIR-4724-3P	97.57	67.31	785

Literature-anchored findings (GeneRIF, showing 4)

• A large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the psoriasis susceptibility gene within the PSORS9 locus. (PMID:16773312)
• characterized the substrate specificity and catalytic properties of purified MGST2 by steady-state and pre-steady-state kinetic experiments (PMID:23409838)
• Trimeric microsomal protein MGST2 displays one third of the sites reactivity. (PMID:26066610)
• Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. (PMID:33741927)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mgst2	ENSDARG00000071345
mus_musculus	Mgst2	ENSMUSG00000074604
rattus_norvegicus	Mgst2	ENSRNOG00000061857

Paralogs (3): ALOX5AP (ENSG00000132965), MGST3 (ENSG00000143198), LTC4S (ENSG00000213316)

Protein

Protein identifiers

Microsomal glutathione S-transferase 2 — Q99735 (reviewed: Q99735)

Alternative names: Glutathione peroxidase MGST2, Leukotriene C4 synthase MGST2, Microsomal glutathione S-transferase II

All UniProt accessions (1): Q99735

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.

Subunit / interactions. Homotrimer.

Subcellular location. Endoplasmic reticulum membrane. Microsome membrane.

Tissue specificity. Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow. Abundantly expressed in human umbilical vein endothelial cells (at protein level).

Activity regulation. Each monomer can bind on GSH molecule but only one subunit is catalytically active.

Induction. Upon ER stress with brefeldin A or with tunicamycin, MGST2 is down-regulated, in several non-haematopoietic cell types, during the early, protective phase of the unfolded protein response (UPR), and up-regulated at the late, death-promoting phase of the unfolded protein response (UPR).

Similarity. Belongs to the MAPEG family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q99735-1	1	yes
Q99735-2	2

RefSeq proteins (4): NP_001191295, NP_001191296, NP_001191297, NP_002404* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001129	Membr-assoc_MAPEG	Family
IPR001446	5_LipOase_AP	Family
IPR018295	FLAP/GST2/LTC4S_CS	Conserved_site
IPR023352	MAPEG-like_dom_sf	Homologous_superfamily
IPR050997	MAPEG	Family

Pfam: PF01124

Catalyzed reactions (Rhea), 4 shown:

• RX + glutathione = an S-substituted glutathione + a halide anion + H(+) (RHEA:16437)
• leukotriene C4 = leukotriene A4 + glutathione (RHEA:17617)
• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O (RHEA:48620)
• 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+) (RHEA:51220)

UniProt features (11 total): helix 5, transmembrane region 3, chain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
6SSS	X-RAY DIFFRACTION	2.5
6SSU	X-RAY DIFFRACTION	2.5
6SSW	X-RAY DIFFRACTION	3
6SSR	X-RAY DIFFRACTION	3.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99735-F1	94.54	0.87

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-156590	Glutathione conjugation
R-HSA-5423646	Aflatoxin activation and detoxification
R-HSA-1430728	Metabolism
R-HSA-156580	Phase II - Conjugation of compounds
R-HSA-211859	Biological oxidations

MSigDB gene sets: 329 (showing top): REACTOME_BIOLOGICAL_OXIDATIONS, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_INFLAMMATORY_RESPONSE, HSIAO_HOUSEKEEPING_GENES, LUCAS_HNF4A_TARGETS_UP, GOBP_LEUKOTRIENE_BIOSYNTHETIC_PROCESS, GOBP_MEMBRANE_LIPID_CATABOLIC_PROCESS, GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS, GOMF_GLUTATHIONE_TRANSFERASE_ACTIVITY, GOBP_PEPTIDE_METABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS, MODULE_75, ONKEN_UVEAL_MELANOMA_UP, GOBP_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS

GO Biological Process (9): lipid metabolic process (GO:0006629), glutathione biosynthetic process (GO:0006750), leukotriene biosynthetic process (GO:0019370), response to lipopolysaccharide (GO:0032496), obsolete membrane lipid catabolic process (GO:0046466), positive regulation of inflammatory response (GO:0050729), leukotriene metabolic process (GO:0006691), carboxylic acid biosynthetic process (GO:0046394), cellular oxidant detoxification (GO:0098869)

GO Molecular Function (10): glutathione transferase activity (GO:0004364), leukotriene-C4 synthase activity (GO:0004464), glutathione peroxidase activity (GO:0004602), enzyme activator activity (GO:0008047), identical protein binding (GO:0042802), glutathione binding (GO:0043295), protein binding (GO:0005515), oxidoreductase activity (GO:0016491), transferase activity (GO:0016740), lyase activity (GO:0016829)

GO Cellular Component (6): nuclear envelope (GO:0005635), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), membrane (GO:0016020), intracellular membrane-bounded organelle (GO:0043231)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Biological oxidations	2
Phase II - Conjugation of compounds	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catalytic activity	4
endomembrane system	2
primary metabolic process	1
glutathione metabolic process	1
nonribosomal peptide biosynthetic process	1
modified amino acid biosynthetic process	1
sulfur compound biosynthetic process	1
leukotriene metabolic process	1
icosanoid biosynthetic process	1
response to molecule of bacterial origin	1
response to lipid	1
response to oxygen-containing compound	1
inflammatory response	1
positive regulation of defense response	1
positive regulation of response to external stimulus	1
regulation of inflammatory response	1
icosanoid metabolic process	1
carboxylic acid metabolic process	1
small molecule biosynthetic process	1
cellular detoxification	1
transferase activity, transferring alkyl or aryl (other than methyl) groups	1
carbon-sulfur lyase activity	1
peroxidase activity	1
enzyme regulator activity	1
molecular function activator activity	1
protein binding	1
anion binding	1
modified amino acid binding	1
oligopeptide binding	1
sulfur compound binding	1
binding	1
nucleus	1
organelle envelope	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

636 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MGST2	MGST1	P10620	968
MGST2	PTGES	O14684	850
MGST2	HPGDS	O60760	740
MGST2	GSTO1	P78417	591
MGST2	GPX2	P18283	554
MGST2	GSTK1	Q9Y2Q3	515
MGST2	MGST3	O14880	509
MGST2	GSTO2	Q9H4Y5	499
MGST2	GSTM4	Q03013	446
MGST2	GSTP1	P09211	444
MGST2	GSTM2	P28161	431
MGST2	GSTA5	Q7RTV2	429
MGST2	GSTA1	P08263	428
MGST2	CHAC2	Q8WUX2	397
MGST2	GSTT2B	P0CG30	391

IntAct

83 interactions, top by confidence:

A	B	Type	Score
RELL2	OXSR1	psi-mi:“MI:0914”(association)	0.830
MGST2	CREB3	psi-mi:“MI:0915”(physical association)	0.560
GIMAP5	MGST2	psi-mi:“MI:0915”(physical association)	0.560
STX8	MGST2	psi-mi:“MI:0915”(physical association)	0.560
TTMP	MGST2	psi-mi:“MI:0915”(physical association)	0.560
BCL2L10	MGST2	psi-mi:“MI:0915”(physical association)	0.560
MGST2	GPX8	psi-mi:“MI:0915”(physical association)	0.560
MGST2	TMEM167B	psi-mi:“MI:0915”(physical association)	0.560
SGCB	MGST2	psi-mi:“MI:0915”(physical association)	0.560
CTXN3	MGST2	psi-mi:“MI:0915”(physical association)	0.560
PNKP	MGST2	psi-mi:“MI:0915”(physical association)	0.560
CREB3L1	MGST2	psi-mi:“MI:0915”(physical association)	0.560
SEC22A	MGST2	psi-mi:“MI:0915”(physical association)	0.560
DNAJC30	MGST2	psi-mi:“MI:0915”(physical association)	0.560
PLN	MGST2	psi-mi:“MI:0915”(physical association)	0.560
MGST2	STX8	psi-mi:“MI:0915”(physical association)	0.560
VAMP3	MGST2	psi-mi:“MI:0915”(physical association)	0.560
GJA8	MGST2	psi-mi:“MI:0915”(physical association)	0.560
MGST2	BCL2L10	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (43): CREB3 (Two-hybrid), MGST2 (Reconstituted Complex), MGST2 (Affinity Capture-MS), MGST2 (Affinity Capture-MS), MGST2 (Affinity Capture-MS), MGST2 (Two-hybrid), MGST2 (Two-hybrid), MGST2 (Two-hybrid), ASIC1 (Two-hybrid), C3orf52 (Two-hybrid), SEC22A (Two-hybrid), GJA8 (Two-hybrid), BCL2L2 (Two-hybrid), BCL2L10 (Two-hybrid), CREB3L1 (Two-hybrid)

ESM2 similar proteins: A0A2I1C3V3, A0SYQ0, A1L2F6, A2RST1, A4DA06, A6XA80, A8X8R3, J7FIJ6, O14684, O14880, O74507, O94511, P08011, P0DN89, P10620, P64515, P64516, P70245, P73795, P79382, Q15125, Q16873, Q17428, Q28GF8, Q296J9, Q2KJG4, Q2NKS0, Q3T100, Q41745, Q54GA9, Q57ZC7, Q5R9A6, Q60490, Q60860, Q64L89, Q6GNM0, Q6GPW4, Q6PWL6, Q8HZJ2, Q91VS7

Diamond homologs: A2RST1, A6XA80, O14880, P20291, P20292, P30353, P30354, P30355, P30356, P30357, P30358, P73795, Q148F2, Q16873, Q2KJG4, Q2NKS0, Q2PG08, Q3T100, Q60860, Q925U2, Q99735, Q9CPU4, Q54GA9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

33 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	20
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1728 predictions. Top by Δscore:

Variant	Effect	Δscore
4:139666073:GCAAA:G	donor_gain	1.0000
4:139666078:G:GG	donor_gain	1.0000
4:139678643:G:GG	donor_gain	1.0000
4:139725833:CTG:C	acceptor_gain	1.0000
4:139666076:AA:A	donor_gain	0.9900
4:139666091:G:T	donor_gain	0.9900
4:139678638:GCACA:G	donor_gain	0.9900
4:139679224:G:GT	donor_gain	0.9900
4:139685567:G:GT	donor_gain	0.9900
4:139703453:A:AG	acceptor_gain	0.9900
4:139703454:G:GG	acceptor_gain	0.9900
4:139725745:CCTCA:C	donor_loss	0.9900
4:139725746:CTCA:C	donor_loss	0.9900
4:139725747:T:TA	donor_loss	0.9900
4:139725748:CA:C	donor_loss	0.9900
4:139725749:A:AA	donor_loss	0.9900
4:139725750:C:A	donor_loss	0.9900
4:139725832:ACTGC:A	acceptor_gain	0.9900
4:139725833:CTGCT:C	acceptor_gain	0.9900
4:139725834:TG:T	acceptor_gain	0.9900
4:139725836:C:CC	acceptor_gain	0.9900
4:139730410:TGTTA:T	donor_loss	0.9900
4:139730411:GTTAC:G	donor_loss	0.9900
4:139730412:TTACC:T	donor_loss	0.9900
4:139730413:TA:T	donor_loss	0.9900
4:139730414:A:AG	donor_loss	0.9900
4:139730415:C:CT	donor_loss	0.9900
4:139666075:AAAG:A	donor_loss	0.9800
4:139666076:AAGTA:A	donor_loss	0.9800
4:139666077:AGTA:A	donor_loss	0.9800

AlphaMissense

932 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:139695240:T:A	W68R	0.986
4:139695240:T:C	W68R	0.986
4:139678620:T:C	F46L	0.985
4:139678622:T:A	F46L	0.985
4:139678622:T:G	F46L	0.985
4:139703472:G:C	G83R	0.983
4:139703494:G:C	R90P	0.982
4:139703505:T:C	F94L	0.982
4:139703507:C:A	F94L	0.982
4:139703507:C:G	F94L	0.982
4:139704035:A:C	S111R	0.982
4:139704037:T:A	S111R	0.982
4:139704037:T:G	S111R	0.982
4:139695203:C:A	N55K	0.979
4:139695203:C:G	N55K	0.979
4:139703473:G:A	G83D	0.979
4:139678636:G:C	R51P	0.978
4:139703493:C:A	R90S	0.973
4:139695199:A:C	Q54P	0.968
4:139703514:T:C	Y97H	0.968
4:139678573:G:C	R30T	0.967
4:139695225:T:C	F63L	0.965
4:139695227:C:A	F63L	0.965
4:139695227:C:G	F63L	0.965
4:139704068:G:C	G122R	0.965
4:139678569:G:C	A29P	0.964
4:139695249:G:T	G71W	0.964
4:139678574:A:C	R30S	0.963
4:139678574:A:T	R30S	0.963
4:139678639:C:A	A52E	0.960

dbSNP variants (sampled 300 via entrez): RS1000018558 (4:139695392 T>A,C), RS1000019076 (4:139715245 G>A), RS1000050834 (4:139716498 C>T), RS1000106388 (4:139722771 A>C), RS1000124257 (4:139714837 G>A), RS1000125134 (4:139720676 G>A,C), RS1000142634 (4:139677999 G>A,C), RS1000214299 (4:139739878 T>C), RS1000222 (4:139666831 G>A), RS1000245144 (4:139754888 C>A,T), RS1000258833 (4:139671188 C>T), RS1000269194 (4:139694873 A>C), RS1000306338 (4:139748378 T>C), RS1000306762 (4:139741243 A>C), RS1000320326 (4:139708205 G>A,C,T)

Disease associations

OMIM: gene MIM:601733 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST009391_1771	Metabolite levels	2.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0010478	fructose-1-phosphate measurement
EFO:0010479	fructose-6-phosphate measurement
EFO:0010484	glucose-1-phosphate measurement
EFO:0010485	glucose-6-phosphate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL1743185 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

73 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases expression, increases methylation	4
Cyclosporine	decreases expression, affects cotreatment	4
Acetaminophen	decreases expression, affects cotreatment	3
Tetrachlorodibenzodioxin	decreases expression	3
Valproic Acid	increases expression	3
nefazodone	affects cotreatment, decreases expression	2
entinostat	increases expression, affects cotreatment	2
Temozolomide	affects response to substance, increases expression	2
Chenodeoxycholic Acid	affects cotreatment, decreases expression	2
Cisplatin	affects cotreatment, increases expression, affects expression	2
Deoxycholic Acid	affects cotreatment, decreases expression	2
Glycochenodeoxycholic Acid	affects cotreatment, decreases expression	2
Glycocholic Acid	affects cotreatment, decreases expression	2
Glycodeoxycholic Acid	affects cotreatment, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	decreases expression	2
bismuth tripotassium dicitrate	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
2,2’-methylenebis(4-methyl-6-tert-butylphenol)	affects response to substance, affects expression	1
ethyl-p-hydroxybenzoate	increases expression	1
trichostatin A	increases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	decreases expression	1
indirubin	decreases expression	1
potassium chromate(VI)	decreases expression	1
beta-methylcholine	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
azaspiracid	increases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1743240	ADMET	Substrates for human microsomal glutathione transferase MGST2	Casarett and Doull’s Toxicology The Basic Science of Poisons, 7th edition

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.