MIATNB

Summary

MIATNB (MIAT neighbor, HGNC:50731) is a long non-coding RNA gene on chromosome 22q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50731
Approved symbol	MIATNB
Name	MIAT neighbor
Location	22q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000244625
Ensembl biotype	lncRNA
Entrez	102724827
RNAcentral	URS0000759CB9 — lncRNA, 1682 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 121 — 121 lncRNA

ENST00000417083, ENST00000421253, ENST00000434868, ENST00000435162, ENST00000437071, ENST00000438113, ENST00000440816, ENST00000444388, ENST00000446336, ENST00000447149, ENST00000449017, ENST00000450963, ENST00000651474, ENST00000653531, ENST00000653953, ENST00000658323, ENST00000662474, ENST00000664041, ENST00000664057, ENST00000664301, ENST00000668496, ENST00000669899, ENST00000670559, ENST00000671424, ENST00000716994, ENST00000716995, ENST00000716996, ENST00000716997, ENST00000716998, ENST00000717019, ENST00000717020, ENST00000717021, ENST00000717023, ENST00000717024, ENST00000717025, ENST00000717026, ENST00000717027, ENST00000717028, ENST00000717029, ENST00000717032, ENST00000717033, ENST00000717034, ENST00000717035, ENST00000717036, ENST00000717037, ENST00000717038, ENST00000717039, ENST00000717040, ENST00000717041, ENST00000717042, ENST00000717044, ENST00000717045, ENST00000717068, ENST00000717069, ENST00000717070, ENST00000717071, ENST00000717072, ENST00000717073, ENST00000717074, ENST00000717075, ENST00000717076, ENST00000717077, ENST00000717078, ENST00000717091, ENST00000717092, ENST00000717093, ENST00000717094, ENST00000717095, ENST00000717102, ENST00000717103, ENST00000717104, ENST00000717105, ENST00000717106, ENST00000717107, ENST00000717109, ENST00000717110, ENST00000717111, ENST00000717112, ENST00000717113, ENST00000717114, ENST00000717115, ENST00000717116, ENST00000717117, ENST00000717118, ENST00000717119, ENST00000717120, ENST00000717125, ENST00000717126, ENST00000717127, ENST00000717128, ENST00000717129, ENST00000717130, ENST00000717133, ENST00000717134, ENST00000717135, ENST00000717136, ENST00000717145, ENST00000717146, ENST00000717147, ENST00000717148, ENST00000717149, ENST00000717150, ENST00000717151, ENST00000717152, ENST00000717153, ENST00000717154, ENST00000717155, ENST00000717164, ENST00000717165, ENST00000717166, ENST00000717167, ENST00000717168, ENST00000717169, ENST00000717170, ENST00000717172, ENST00000717173, ENST00000717174, ENST00000717180, ENST00000717213, ENST00000717214, ENST00000850667

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417083 — 7 exons

Exon	Start	End
ENSE00004031479	26698997	26699138
ENSE00004031480	26672825	26672987
ENSE00004031648	26711830	26712008
ENSE00004031655	26693681	26693836
ENSE00004031913	26721650	26722172
ENSE00004031914	26717253	26717459
ENSE00004031915	26718140	26718231

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 88.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.4714 / max 160.7848, expressed in 1729 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191529	4.1196	1599
191531	3.6214	1190
191530	0.7304	271

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	88.91	gold quality
sural nerve	UBERON:0015488	88.65	gold quality
colonic epithelium	UBERON:0000397	86.35	gold quality
granulocyte	CL:0000094	86.26	gold quality
blood	UBERON:0000178	85.06	gold quality
lower esophagus mucosa	UBERON:0035834	84.88	gold quality
leukocyte	CL:0000738	84.78	gold quality
monocyte	CL:0000576	84.66	gold quality
spleen	UBERON:0002106	84.18	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.14	gold quality
lymph node	UBERON:0000029	83.10	gold quality
rectum	UBERON:0001052	82.27	gold quality
vermiform appendix	UBERON:0001154	82.11	gold quality
small intestine Peyer’s patch	UBERON:0003454	81.79	gold quality
ectocervix	UBERON:0012249	81.44	gold quality
right lobe of thyroid gland	UBERON:0001119	81.41	gold quality
left lobe of thyroid gland	UBERON:0001120	81.38	gold quality
skin of abdomen	UBERON:0001416	81.30	gold quality
mucosa of transverse colon	UBERON:0004991	80.87	gold quality
thyroid gland	UBERON:0002046	80.69	gold quality
minor salivary gland	UBERON:0001830	80.67	gold quality
adenohypophysis	UBERON:0002196	80.56	gold quality
popliteal artery	UBERON:0002250	80.31	gold quality
tibial artery	UBERON:0007610	80.30	gold quality
apex of heart	UBERON:0002098	80.12	gold quality
ascending aorta	UBERON:0001496	80.10	gold quality
esophagus mucosa	UBERON:0002469	80.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.98	gold quality
small intestine	UBERON:0002108	79.96	gold quality
smooth muscle tissue	UBERON:0001135	79.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long Noncoding RNA MIATNB Regulates Hyperosmotic Stress-induced Corneal Epithelial Cell Injury by Inhibiting Autophagy in Dry Eye Disease. (PMID:37317543)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.