MICALL2

Summary

MICALL2 (MICAL like 2, HGNC:29672) is a protein-coding gene on chromosome 7p22.3, encoding MICAL-like protein 2 (Q8IY33). Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization.

Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; recycling endosome; and stress fiber.

Source: NCBI Gene 79778 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 315 total — 1 pathogenic
• MANE Select transcript: NM_182924

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29672
Approved symbol	MICALL2
Name	MICAL like 2
Location	7p22.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC46023, FLJ23471, MICAL-L2, JRAB
Ensembl gene	ENSG00000164877
Ensembl biotype	protein_coding
OMIM	620912
Entrez	79778

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 12 retained_intron, 6 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000297508, ENST00000413446, ENST00000460198, ENST00000467394, ENST00000467783, ENST00000470807, ENST00000471899, ENST00000472100, ENST00000479007, ENST00000482839, ENST00000487156, ENST00000487187, ENST00000490608, ENST00000493998, ENST00000496184, ENST00000873414, ENST00000873415, ENST00000873416, ENST00000873417, ENST00000912207

RefSeq mRNA: 1 — MANE Select: NM_182924 NM_182924

CCDS: CCDS5324

Canonical transcript exons

ENST00000297508 — 17 exons

Exon	Start	End
ENSE00001088213	1442192	1442484
ENSE00001182998	1440591	1440684
ENSE00001898295	1459184	1459470
ENSE00003473828	1446713	1446828
ENSE00003482138	1437890	1437980
ENSE00003495529	1444652	1445428
ENSE00003495980	1435101	1435147
ENSE00003510778	1448620	1448761
ENSE00003528667	1447575	1447765
ENSE00003568818	1438289	1438353
ENSE00003574084	1434359	1434672
ENSE00003614728	1436742	1436856
ENSE00003623870	1438840	1438995
ENSE00003647851	1438097	1438220
ENSE00003652316	1439925	1440085
ENSE00003670567	1450240	1450288
ENSE00003672334	1437535	1437608

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 98.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.5387 / max 742.3218, expressed in 1733 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82411	7.2379	1566
82413	2.9284	1475
82412	0.3724	161

Top tissues by expression

274 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial nerve	UBERON:0001323	98.36	gold quality
sural nerve	UBERON:0015488	98.34	gold quality
right adrenal gland cortex	UBERON:0035827	97.46	gold quality
right adrenal gland	UBERON:0001233	97.38	gold quality
mucosa of transverse colon	UBERON:0004991	97.36	gold quality
left adrenal gland cortex	UBERON:0035825	97.13	gold quality
left adrenal gland	UBERON:0001234	96.92	gold quality
lower esophagus mucosa	UBERON:0035834	95.96	gold quality
spleen	UBERON:0002106	95.71	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.69	gold quality
adrenal cortex	UBERON:0001235	95.64	gold quality
transverse colon	UBERON:0001157	95.15	gold quality
body of stomach	UBERON:0001161	95.08	gold quality
right uterine tube	UBERON:0001302	94.92	gold quality
right frontal lobe	UBERON:0002810	94.82	gold quality
right coronary artery	UBERON:0001625	94.20	gold quality
adenohypophysis	UBERON:0002196	93.94	gold quality
adrenal gland	UBERON:0002369	93.87	gold quality
small intestine	UBERON:0002108	93.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.64	gold quality
metanephros cortex	UBERON:0010533	93.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.30	gold quality
anterior cingulate cortex	UBERON:0009835	93.17	gold quality
cingulate cortex	UBERON:0003027	93.01	gold quality
mucosa of stomach	UBERON:0001199	92.98	gold quality
descending thoracic aorta	UBERON:0002345	92.68	gold quality
amygdala	UBERON:0001876	92.18	gold quality
ascending aorta	UBERON:0001496	92.17	gold quality
left coronary artery	UBERON:0001626	92.15	gold quality
endocervix	UBERON:0000458	92.11	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-100618	yes	10.99
E-ANND-3	yes	6.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

2 targeting MICALL2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-135A-2-3P	98.40	66.74	442
HSA-MIR-135B-3P	98.40	67.35	426

Literature-anchored findings (GeneRIF, showing 7)

• Involved in epithelial cell scattering. (PMID:17891173)
• Data indicate that MICAL-L2 may be an important regulator of epithelial-mesenchymal transition (EMT) in ovarian cancer cells. (PMID:25864591)
• We identified one new significant locus at 7p22.3 for the Stroop word interference time (rs11514810, P=3.42E-09 for discovery, P=0.01176 for replication and combined P=5.249E-09). Regulatory feature analysis and expression quantitative trait loci (eQTL) data showed that this locus contributes to MICALL2 expression in the human brain. (PMID:28416812)
• Up-regulation of MICAL-L2 is associated with gastric cancer cell migration. (PMID:31034158)
• JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes. (PMID:33976349)
• MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer. (PMID:36307841)
• Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion. (PMID:38203692)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	micall2b	ENSDARG00000017834
danio_rerio	micall2a	ENSDARG00000102366
mus_musculus	Micall2	ENSMUSG00000036718
rattus_norvegicus	Micall2	ENSRNOG00000022533
drosophila_melanogaster	Ehbp1	FBGN0034180

Paralogs (7): ASPM (ENSG00000066279), MICALL1 (ENSG00000100139), EHBP1 (ENSG00000115504), GAS2 (ENSG00000148935), EHBP1L1 (ENSG00000173442), GAS2L1 (ENSG00000185340), SMTNL1 (ENSG00000214872)

Protein

Protein identifiers

MICAL-like protein 2 — Q8IY33 (reviewed: Q8IY33)

Alternative names: Junctional Rab13-binding protein, Molecule interacting with CasL-like 2

All UniProt accessions (1): Q8IY33

UniProt curated annotations — full annotation on UniProt →

Function. Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth. Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation.

Subunit / interactions. Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling. Interacts with RAB8B. Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation. Interacts (via calponin-homology (CH) domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).

Subcellular location. Cell membrane. Cell junction. Tight junction. Recycling endosome. Cell projection. Cytoplasm. Cytoskeleton.

Domain organisation. Exists in a closed and an open conformation due to interaction of the C-terminal coiled-coil domain with an N-terminal region including the calponin-homology (CH) and the LIM zinc-binding domain. The conformational change is regulated by RAB13 and RAB8A. Adopts its closed form upon interaction with RAB8A and interaction with RAB13 causes conformational change from closed to open.

Isoforms (5)

UniProt ID	Names	Canonical?
Q8IY33-1	1	yes
Q8IY33-2	2
Q8IY33-3	3
Q8IY33-4	4
Q8IY33-5	5

RefSeq proteins (1): NP_891554* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001715	CH_dom	Domain
IPR001781	Znf_LIM	Domain
IPR022735	bMERB_dom	Domain
IPR036872	CH_dom_sf	Homologous_superfamily
IPR050540	F-actin_Monoox_Mical	Family

Pfam: PF00307, PF00412, PF12130

UniProt features (50 total): compositionally biased region 13, modified residue 13, region of interest 7, splice variant 5, sequence variant 4, domain 3, sequence conflict 3, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IY33-F1	56.94	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (13): 110, 143, 153, 249, 294, 494, 504, 598, 644, 649, 658, 660, 726

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 141 (showing top): GOBP_ENDOSOME_ORGANIZATION, PEREZ_TP63_TARGETS, GOBP_VESICLE_ORGANIZATION, GOBP_APICAL_JUNCTION_ASSEMBLY, GOBP_PROTEIN_TARGETING, GOBP_NEUROGENESIS, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOMF_GTPASE_BINDING, chr7p22, GOBP_CELL_JUNCTION_ORGANIZATION, GOBP_ACTIN_FILAMENT_ORGANIZATION, GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION, GOBP_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION

GO Biological Process (9): actin cytoskeleton organization (GO:0030036), actin filament polymerization (GO:0030041), neuron projection development (GO:0031175), endocytic recycling (GO:0032456), Rab protein signal transduction (GO:0032482), substrate adhesion-dependent cell spreading (GO:0034446), bicellular tight junction assembly (GO:0070830), endosome membrane tubulation (GO:0097750), obsolete positive regulation of protein targeting to mitochondrion (GO:1903955)

GO Molecular Function (6): filamin binding (GO:0031005), small GTPase binding (GO:0031267), actinin binding (GO:0042805), metal ion binding (GO:0046872), actin filament binding (GO:0051015), protein binding (GO:0005515)

GO Cellular Component (13): stress fiber (GO:0001725), plasma membrane (GO:0005886), cell-cell junction (GO:0005911), bicellular tight junction (GO:0005923), neuron projection (GO:0043005), recycling endosome (GO:0055037), cytoplasm (GO:0005737), endosome (GO:0005768), cytoskeleton (GO:0005856), membrane (GO:0016020), actin filament bundle (GO:0032432), cell projection (GO:0042995), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoskeletal protein binding	2
cytoskeleton organization	1
actin filament-based process	1
actin polymerization or depolymerization	1
protein polymerization	1
neuron development	1
plasma membrane bounded cell projection organization	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
small GTPase-mediated signal transduction	1
cell-substrate adhesion	1
apical junction assembly	1
tight junction assembly	1
endosome organization	1
membrane tubulation	1
GTPase binding	1
cation binding	1
actin binding	1
protein-containing complex binding	1
binding	1
actomyosin	1
contractile actin filament bundle	1
membrane	1
cell periphery	1
anchoring junction	1
apical junction complex	1
tight junction	1
plasma membrane bounded cell projection	1
endosome	1
intracellular anatomical structure	1
endomembrane system	1
cytoplasmic vesicle	1
intracellular membraneless organelle	1
actin filament	1
actin cytoskeleton	1
cell junction	1

Protein interactions and networks

STRING

862 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MICALL2	RAB13	P51153	935
MICALL2	RAB8A	P24407	802
MICALL2	NEDD9	Q14511	701
MICALL2	RAB10	P61026	585
MICALL2	ACTN4	O43707	536
MICALL2	RAB35	Q15286	511
MICALL2	ALS2CL	Q60I27	459
MICALL2	GRB2	P29354	445
MICALL2	RAB27B	O00194	424
MICALL2	RAB36	O95755	421
MICALL2	RAB12	Q6IQ22	405
MICALL2	MAPKAP1	Q9BPZ7	397
MICALL2	TLE1	Q04724	388
MICALL2	DOCK1	Q14185	376
MICALL2	PDPN	Q86YL7	374
MICALL2	GLI2	P10070	374

IntAct

48 interactions, top by confidence:

A	B	Type	Score
ACTN2	MICALL2	psi-mi:“MI:0915”(physical association)	0.780
MICALL2	ACTN2	psi-mi:“MI:0915”(physical association)	0.780
PIGS	GPAA1	psi-mi:“MI:0914”(association)	0.760
MICALL2	ACTN1	psi-mi:“MI:0915”(physical association)	0.720
ACTN1	MICALL2	psi-mi:“MI:0915”(physical association)	0.720
RAB8A	WDR91	psi-mi:“MI:0914”(association)	0.600
MICALL2	CDR2	psi-mi:“MI:0915”(physical association)	0.560
ACTN3	MICALL2	psi-mi:“MI:0915”(physical association)	0.560
ACTN4	MICALL2	psi-mi:“MI:0915”(physical association)	0.560
MICALL2	DCDC2	psi-mi:“MI:0915”(physical association)	0.560
RAB8B	BLTP3B	psi-mi:“MI:0914”(association)	0.530
MICALL2	ERP29	psi-mi:“MI:0915”(physical association)	0.400
Rab8a	RAB8A	psi-mi:“MI:0915”(physical association)	0.400
Hdac6	TDG	psi-mi:“MI:0914”(association)	0.350
FGD1		psi-mi:“MI:0914”(association)	0.350
Kif13b	TCF3	psi-mi:“MI:0914”(association)	0.350
NES	RPL10	psi-mi:“MI:0914”(association)	0.350
ZNF281	KIF21B	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
MYC	PDZD2	psi-mi:“MI:0914”(association)	0.350

BioGRID (149): MICALL2 (Two-hybrid), MICALL2 (Two-hybrid), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Proximity Label-MS), MICALL2 (Affinity Capture-MS), MICALL2 (Two-hybrid), MICALL2 (Two-hybrid), MICALL2 (Two-hybrid)

ESM2 similar proteins: A1L1I3, A5PKW4, O08919, O70405, O75385, O75420, O75553, P16554, P42128, P49757, P53814, P85037, P97318, P98081, Q04637, Q2LC84, Q3UCQ1, Q4KMP7, Q5DTT2, Q5I1X5, Q5RBR0, Q5VZ18, Q69ZH9, Q69ZI1, Q7TN02, Q7Z6J0, Q80VC9, Q80XI3, Q80Z38, Q86V15, Q8BGT6, Q8BHL3, Q8BSD5, Q8C120, Q8CI12, Q8IY33, Q8K4J6, Q8N3F8, Q8TEH3, Q8TEJ3

Diamond homologs: A5D7D1, D3ZEN0, D3ZHA0, D3ZHV2, D3ZQL6, E1BBG2, F1MF74, F1RA39, F6QZ15, G3MWR8, G3V7L1, L7UZ85, M9MRD1, O13728, O15020, O43707, O75369, O76329, O88990, O94851, O97592, P05094, P05095, P07751, P11277, P11530, P11531, P11532, P11533, P12814, P13395, P13466, P15508, P16086, P16546, P18091, P20111, P21333, P30427, P35609

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 37 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
actin cytoskeleton organization	5	12.4×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

315 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	219
Likely benign	29
Benign	25

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
375381	NM_182924.4(MICALL2):c.851C>G (p.Pro284Arg)	Pathogenic

SpliceAI

3346 predictions. Top by Δscore:

Variant	Effect	Δscore
7:1435100:CCCAG:C	donor_gain	1.0000
7:1435104:G:C	donor_gain	1.0000
7:1436738:TCACC:T	donor_loss	1.0000
7:1436740:A:AC	donor_gain	1.0000
7:1436740:ACCGG:A	donor_loss	1.0000
7:1436741:C:CC	donor_gain	1.0000
7:1436741:CCGGA:C	donor_loss	1.0000
7:1436751:T:TA	donor_gain	1.0000
7:1436757:T:TA	donor_gain	1.0000
7:1436855:CT:C	acceptor_gain	1.0000
7:1437534:CCGGG:C	donor_gain	1.0000
7:1437888:A:AC	donor_gain	1.0000
7:1437889:C:CC	donor_gain	1.0000
7:1438091:GCTCA:G	donor_loss	1.0000
7:1438092:CTCA:C	donor_loss	1.0000
7:1438093:TCAC:T	donor_loss	1.0000
7:1438094:CA:C	donor_loss	1.0000
7:1438095:ACCT:A	donor_gain	1.0000
7:1438095:ACCTC:A	donor_gain	1.0000
7:1438096:C:CG	donor_loss	1.0000
7:1438096:CCT:C	donor_gain	1.0000
7:1438096:CCTC:C	donor_gain	1.0000
7:1438096:CCTCC:C	donor_gain	1.0000
7:1438098:T:TA	donor_gain	1.0000
7:1438099:C:A	donor_gain	1.0000
7:1438216:TGCAG:T	acceptor_gain	1.0000
7:1438217:GCAG:G	acceptor_gain	1.0000
7:1438218:CAG:C	acceptor_gain	1.0000
7:1438218:CAGC:C	acceptor_gain	1.0000
7:1438219:A:T	acceptor_gain	1.0000

AlphaMissense

5814 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:1448672:G:C	S94R	0.999
7:1448672:G:T	S94R	0.999
7:1448674:T:G	S94R	0.999
7:1448756:G:C	F66L	0.999
7:1448756:G:T	F66L	0.999
7:1448758:A:G	F66L	0.999
7:1459214:G:T	A38D	0.999
7:1459229:C:A	G33V	0.999
7:1459237:G:C	F30L	0.999
7:1459237:G:T	F30L	0.999
7:1459238:A:G	F30S	0.999
7:1459239:A:G	F30L	0.999
7:1437951:A:G	W781R	0.998
7:1437951:A:T	W781R	0.998
7:1448685:G:T	P90H	0.998
7:1448748:G:T	A69D	0.998
7:1459196:C:G	R44P	0.998
7:1459229:C:T	G33D	0.998
7:1459230:C:A	G33C	0.998
7:1459230:C:G	G33R	0.998
7:1459294:G:C	C11W	0.998
7:1459297:C:A	W10C	0.998
7:1459297:C:G	W10C	0.998
7:1459299:A:G	W10R	0.998
7:1459299:A:T	W10R	0.998
7:1438114:A:G	L765P	0.997
7:1448637:A:G	F106S	0.997
7:1448718:A:G	L79P	0.997
7:1448730:A:G	I75T	0.997
7:1448757:A:G	F66S	0.997

dbSNP variants (sampled 300 via entrez): RS1000038642 (7:1438597 C>T), RS1000059251 (7:1457924 T>C), RS1000103978 (7:1435821 G>A), RS1000132250 (7:1458300 C>T), RS1000285753 (7:1447485 C>T), RS1000301533 (7:1443736 A>G), RS1000415761 (7:1443882 G>A,C), RS1000467377 (7:1443276 A>C,G), RS1000506803 (7:1458914 C>T), RS1000529572 (7:1453396 G>A,C), RS1000551455 (7:1436634 T>A,C), RS1000552809 (7:1450535 C>T), RS1000574090 (7:1447302 C>A,T), RS1000659789 (7:1450687 G>A), RS1000710216 (7:1435599 C>G,T)

Disease associations

OMIM: gene MIM:620912 | disease phenotypes: MIM:213300

GenCC curated gene-disease

Mondo (1): Joubert syndrome 1 (MONDO:0008944)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST002934_21	Zinc levels	8.000000e-06
GCST004336_1	Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder	5.000000e-09
GCST005983_32	Serum uric acid levels	3.000000e-08
GCST005984_32	Glomerular filtration rate	9.000000e-39
GCST005985_50	Creatinine levels	1.000000e-37
GCST005986_37	Blood urea nitrogen levels	2.000000e-31
GCST005994_2	Hematocrit	1.000000e-14
GCST005995_14	Hemoglobin	2.000000e-14
GCST005996_26	Red blood cell count	3.000000e-12
GCST007725_34	Serum uric acid levels	5.000000e-10
GCST009103_1	Resistance to antihypertensive treatment in hypertension	4.000000e-07
GCST011995_3	Restless legs syndrome	2.000000e-18

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007969	cognitive inhibition measurement
EFO:0004761	uric acid measurement
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement
EFO:0004305	erythrocyte count
EFO:1002006	treatment-resistant hypertension

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation, increases expression	3
bisphenol A	decreases expression, decreases methylation	2
sodium arsenite	decreases expression, increases abundance	2
Arsenic	affects methylation, decreases expression, increases abundance	2
Aflatoxin B1	increases expression, affects expression	2
Particulate Matter	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, decreases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	affects expression	1
avobenzone	increases expression	1
clothianidin	decreases expression	1
abrine	increases expression	1
licochalcone B	increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Amiodarone	increases expression	1
Caffeine	decreases phosphorylation	1
Cisplatin	increases expression	1
Coumestrol	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	increases expression	1
Estradiol	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Methyl Methanesulfonate	increases expression	1
Quercetin	increases expression	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.