MIER3

Summary

MIER3 (MIER family member 3, HGNC:26678) is a protein-coding gene on chromosome 5q11.2, encoding Mesoderm induction early response protein 3 (Q7Z3K6). Transcriptional repressor.

Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. Implicated in breast cancer and lung adenocarcinoma. Biomarker of breast cancer; invasive ductal carcinoma; and lung non-small cell carcinoma.

Source: NCBI Gene 166968 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_001297599

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26678
Approved symbol	MIER3
Name	MIER family member 3
Location	5q11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ35954, DKFZp686L09111, DKFZp781I1119
Ensembl gene	ENSG00000155545
Ensembl biotype	protein_coding
OMIM	620100
Entrez	166968

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 7 protein_coding, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000336942, ENST00000381199, ENST00000381213, ENST00000381226, ENST00000409421, ENST00000440000, ENST00000451637, ENST00000452157, ENST00000480115, ENST00000497185, ENST00000546593, ENST00000861254

RefSeq mRNA: 3 — MANE Select: NM_001297599 NM_001297598, NM_001297599, NM_152622

CCDS: CCDS3973, CCDS75248, CCDS78011

Canonical transcript exons

ENST00000381199 — 13 exons

Exon	Start	End
ENSE00001551467	56952094	56952123
ENSE00001607917	56919603	56923585
ENSE00003462610	56946926	56947071
ENSE00003463014	56930664	56930745
ENSE00003472695	56938883	56939017
ENSE00003508492	56923915	56924042
ENSE00003525693	56928767	56928861
ENSE00003541290	56923691	56923833
ENSE00003570352	56950628	56950652
ENSE00003591504	56935428	56935500
ENSE00003608241	56937578	56937698
ENSE00003636883	56933247	56933398
ENSE00003640242	56935666	56935751

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 97.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.2446 / max 253.7529, expressed in 1583 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
61755	5.0747	1576
61756	0.1699	59

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	97.13	gold quality
jejunal mucosa	UBERON:0000399	95.99	gold quality
buccal mucosa cell	CL:0002336	95.92	gold quality
colonic mucosa	UBERON:0000317	95.45	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.98	gold quality
rectum	UBERON:0001052	91.87	gold quality
colonic epithelium	UBERON:0000397	89.72	gold quality
duodenum	UBERON:0002114	89.68	gold quality
mucosa of transverse colon	UBERON:0004991	89.55	gold quality
secondary oocyte	CL:0000655	89.12	gold quality
parietal pleura	UBERON:0002400	88.76	gold quality
germinal epithelium of ovary	UBERON:0001304	88.56	gold quality
calcaneal tendon	UBERON:0003701	88.54	gold quality
palpebral conjunctiva	UBERON:0001812	88.38	gold quality
visceral pleura	UBERON:0002401	88.28	gold quality
transverse colon	UBERON:0001157	87.71	gold quality
oviduct epithelium	UBERON:0004804	87.36	gold quality
jejunum	UBERON:0002115	87.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.14	gold quality
pigmented layer of retina	UBERON:0001782	86.69	gold quality
adrenal tissue	UBERON:0018303	86.63	gold quality
endometrium	UBERON:0001295	86.48	gold quality
mucosa of paranasal sinus	UBERON:0005030	86.36	gold quality
ventricular zone	UBERON:0003053	86.31	gold quality
large intestine	UBERON:0000059	86.19	gold quality
colon	UBERON:0001155	85.85	gold quality
islet of Langerhans	UBERON:0000006	85.56	gold quality
tibia	UBERON:0000979	85.52	gold quality
intestine	UBERON:0000160	85.46	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.33

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

356 targeting MIER3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5692A	100.00	74.40	6850
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-6077	99.99	68.04	2299

Literature-anchored findings (GeneRIF, showing 4)

• Data suggest that the human 5q11.2 breast cancer risk allele marked by rs889312 is mammary gland autonomous, and MIER3 is a candidate breast cancer susceptibility gene. (PMID:22993404)
• Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity. (PMID:28046085)
• our data suggested that MIER3 plays a potential tumor suppressor role in CRC progression and may be a potentially valuable clinical prognostic marker of this disease. (PMID:28887525)
• MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail. (PMID:34242623)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	mier3a	ENSDARG00000006253
danio_rerio	mier3b	ENSDARG00000021288
mus_musculus	Mier3	ENSMUSG00000032727
rattus_norvegicus	Mier3	ENSRNOG00000013121
drosophila_melanogaster	CG1620	FBGN0033183
caenorhabditis_elegans		WBGENE00017352
caenorhabditis_elegans		WBGENE00020320

Paralogs (5): MTA3 (ENSG00000057935), MIER2 (ENSG00000105556), MTA2 (ENSG00000149480), MTA1 (ENSG00000182979), MIER1 (ENSG00000198160)

Protein

Protein identifiers

Mesoderm induction early response protein 3 — Q7Z3K6 (reviewed: Q7Z3K6)

All UniProt accessions (4): Q7Z3K6, A8MQD4, C9JXP7, H7C1J9

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional repressor.

Subcellular location. Nucleus.

Isoforms (5)

UniProt ID	Names	Canonical?
Q7Z3K6-1	1	yes
Q7Z3K6-2	2
Q7Z3K6-3	3
Q7Z3K6-4	4
Q7Z3K6-5	5

RefSeq proteins (3): NP_001284527, NP_001284528, NP_689835 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000949	ELM2_dom	Domain
IPR001005	SANT/Myb	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017884	SANT_dom	Domain
IPR040138	MIER/MTA	Family
IPR045787	MIER1/3_C	Domain

Pfam: PF00249, PF01448, PF19426

UniProt features (26 total): modified residue 7, splice variant 5, sequence variant 4, compositionally biased region 4, domain 2, region of interest 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z3K6-F1	59.10	0.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 53, 114, 156, 163, 165, 168, 52

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 255 (showing top): TGCACTT_MIR519C_MIR519B_MIR519A, AAGCCAT_MIR135A_MIR135B, GCAAGGA_MIR502, ATGCAGT_MIR217, CACCAGC_MIR138, CTATGCA_MIR153, ACTGCAG_MIR173P, FOSTER_TOLERANT_MACROPHAGE_UP, WTGAAAT_UNKNOWN, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, ACTTTAT_MIR1425P, CAAGGAT_MIR362, CGTCTTA_MIR208, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, TTTGCAC_MIR19A_MIR19B

GO Biological Process (1): negative regulation of transcription by RNA polymerase II (GO:0000122)

GO Molecular Function (3): transcription corepressor activity (GO:0003714), histone deacetylase binding (GO:0042826), protein binding (GO:0005515)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), protein-containing complex (GO:0032991)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of DNA-templated transcription	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
transcription coregulator activity	1
enzyme binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
cellular_component	1

Protein interactions and networks

STRING

872 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MIER3	SETD9	Q8NE22	604
MIER3	HDAC1	Q13547	494
MIER3	BAHD1	Q8TBE0	488
MIER3	HDAC2	Q92769	483
MIER3	DYTN	A2CJ06	441
MIER3	MIER1	Q8N108	405
MIER3	TULP4	Q9NRJ4	374
MIER3	MAP3K1	Q13233	364
MIER3	PRMT2	P55345	359
MIER3	SMIM5	Q71RC9	359
MIER3	ZKSCAN8	Q15776	357
MIER3	CTBS	Q01459	357
MIER3	MRPS30	Q9NP92	351
MIER3	ANAPC15	P60006	345
MIER3	LSP1	P33241	327

IntAct

33 interactions, top by confidence:

A	B	Type	Score
HDAC2	KDM1A	psi-mi:“MI:0914”(association)	0.890
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
H2AZ1	ZNHIT1	psi-mi:“MI:0914”(association)	0.770
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
HDAC1	ZNF609	psi-mi:“MI:0914”(association)	0.730
H2AC4	PPM1G	psi-mi:“MI:0914”(association)	0.670
H2BC1	PPM1G	psi-mi:“MI:0914”(association)	0.640
C16orf87	CDC27	psi-mi:“MI:0914”(association)	0.640
H2BC26	PPM1G	psi-mi:“MI:0914”(association)	0.530
H2AC20	PPM1G	psi-mi:“MI:0914”(association)	0.530
WIZ	RPP30	psi-mi:“MI:0914”(association)	0.350
HDAC1		psi-mi:“MI:0914”(association)	0.350
HDAC2		psi-mi:“MI:0914”(association)	0.350
H2AC11	U2SURP	psi-mi:“MI:0914”(association)	0.350
H2AJ	WDR46	psi-mi:“MI:0914”(association)	0.350
MIER3	BAHD1	psi-mi:“MI:0914”(association)	0.350
H2AC11		psi-mi:“MI:0914”(association)	0.350
H2AC4	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
H2AZ1	PPM1G	psi-mi:“MI:0914”(association)	0.350

BioGRID (32): MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-RNA), MIER3 (Affinity Capture-MS), MIER3 (Two-hybrid), MCRS1 (Two-hybrid), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), HDAC2 (Affinity Capture-MS), MIER3 (Affinity Capture-MS), MIER3 (Affinity Capture-MS)

ESM2 similar proteins: A2AKB4, A4D2P6, A5PJX4, D3Z9H7, F5GYI3, G3V9M2, P04198, P07516, P18302, P49796, Q0QWG9, Q0X0E2, Q14DQ1, Q2KI80, Q3SYZ3, Q3TVI4, Q3U3N0, Q3UHF3, Q4R3R9, Q5FVJ4, Q5FVM5, Q5SYB0, Q5T7N3, Q5UEM8, Q60829, Q68CJ9, Q6J4I0, Q6P9J5, Q6UXB0, Q7Z3K6, Q80UZ0, Q8BRJ3, Q8BWU3, Q8C4S8, Q8N344, Q8NC24, Q8NE31, Q8TEY5, Q8VIP2, Q91XE9

Diamond homologs: A5PJX4, O75376, Q3U3N0, Q3UHF3, Q4KKX4, Q4R3R9, Q5REE1, Q5UAK0, Q5ZKT9, Q60974, Q7T105, Q7Z3K6, Q8N108, Q8N344, Q9WU42, Q9Y618, Q4R2Z8, Q62599, Q8K4B0, Q9H0D2, Q8BXJ2, Q96PN7, Q90WN5, Q0GGX2, Q13330, Q62901, Q80TZ9, Q9P2R6, Q18919, Q6PJG2, Q59E36, Q5FWT8, Q5ZJ40, Q6NRZ0, Q6P116, Q6PGA0, Q8C796, Q8CFE3, Q8IZ40, Q8QG78

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 27 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Packaging Of Telomere Ends	6	69.3×	2e-09
NuRD complex assembly	9	66.8×	5e-13
Recognition and association of DNA glycosylase with site containing an affected purine	6	64.4×	3e-09
Cleavage of the damaged purine	6	64.4×	3e-09
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	8	64.1×	6e-12
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	7	61.9×	2e-10
Interaction of NuRD complexes with transcription factors	9	60.1×	6e-13
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	6	58.2×	4e-09

GO biological processes:

GO term	Partners	Fold	FDR
heterochromatin formation	9	91.9×	4e-14

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2370 predictions. Top by Δscore:

Variant	Effect	Δscore
5:56923581:CAAAG:C	acceptor_gain	1.0000
5:56923582:AAAG:A	acceptor_gain	1.0000
5:56923583:AAG:A	acceptor_gain	1.0000
5:56923584:AG:A	acceptor_gain	1.0000
5:56923586:C:CC	acceptor_gain	1.0000
5:56923586:CTA:C	acceptor_loss	1.0000
5:56923587:T:C	acceptor_loss	1.0000
5:56923685:TTTTA:T	donor_loss	1.0000
5:56923686:TTTAC:T	donor_loss	1.0000
5:56923687:TTAC:T	donor_loss	1.0000
5:56923688:TACCT:T	donor_loss	1.0000
5:56923689:ACC:A	donor_loss	1.0000
5:56923690:CCT:C	donor_loss	1.0000
5:56923832:CC:C	acceptor_gain	1.0000
5:56923833:CC:C	acceptor_gain	1.0000
5:56923913:A:AC	donor_gain	1.0000
5:56923914:C:CC	donor_gain	1.0000
5:56923914:CGTAA:C	donor_gain	1.0000
5:56930658:TCTTA:T	donor_loss	1.0000
5:56930659:CTTA:C	donor_loss	1.0000
5:56930660:TTA:T	donor_loss	1.0000
5:56930661:TA:T	donor_loss	1.0000
5:56930662:ACCT:A	donor_loss	1.0000
5:56933395:TATA:T	acceptor_gain	1.0000
5:56933396:ATA:A	acceptor_gain	1.0000
5:56933397:TA:T	acceptor_gain	1.0000
5:56933399:C:CC	acceptor_gain	1.0000
5:56935422:CCTTA:C	donor_loss	1.0000
5:56935423:CTTA:C	donor_loss	1.0000
5:56935424:TTAC:T	donor_loss	1.0000

AlphaMissense

3682 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:56923992:C:A	K325N	1.000
5:56923992:C:G	K325N	1.000
5:56923995:C:A	W324C	1.000
5:56923995:C:G	W324C	1.000
5:56923997:A:G	W324R	1.000
5:56923997:A:T	W324R	1.000
5:56924006:A:C	Y321D	1.000
5:56924016:A:C	C317W	1.000
5:56924031:C:A	R312S	1.000
5:56924031:C:G	R312S	1.000
5:56928780:A:T	I304K	1.000
5:56928788:A:C	F301L	1.000
5:56928788:A:T	F301L	1.000
5:56928789:A:G	F301S	1.000
5:56928790:A:G	F301L	1.000
5:56928795:T:A	K299I	1.000
5:56928822:A:G	F290S	1.000
5:56928845:C:A	W282C	1.000
5:56928845:C:G	W282C	1.000
5:56928847:A:G	W282R	1.000
5:56928847:A:T	W282R	1.000
5:56930732:A:G	L254P	1.000
5:56937679:A:G	L112P	1.000
5:56937691:A:T	I108K	1.000
5:56923982:G:T	R329S	0.999
5:56923988:A:G	S327P	0.999
5:56923993:T:A	K325M	0.999
5:56923993:T:G	K325T	0.999
5:56923994:T:C	K325E	0.999
5:56923996:C:G	W324S	0.999

dbSNP variants (sampled 300 via entrez): RS1000028732 (5:56946599 AG>A), RS1000029254 (5:56924297 G>A,C), RS1000060002 (5:56946743 G>A), RS1000094389 (5:56952271 C>A,T), RS1000103388 (5:56952774 G>A,C), RS1000215380 (5:56946372 T>C), RS1000307436 (5:56941128 A>G), RS1000355473 (5:56940420 A>T), RS1000388445 (5:56940725 G>C,T), RS1000389311 (5:56933010 T>C), RS1000516037 (5:56947722 T>G), RS1000588712 (5:56946092 A>G), RS1000699130 (5:56942008 G>A,T), RS1000704966 (5:56927202 G>A), RS1000729749 (5:56942405 T>A)

Disease associations

OMIM: gene MIM:620100 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST005956_55	Waist-to-hip ratio adjusted for BMI	9.000000e-06
GCST005957_9	Waist-to-hip ratio adjusted for BMI (age <50)	2.000000e-07
GCST005962_24	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	3.000000e-08
GCST008151_101	Waist circumference	2.000000e-06
GCST008160_103	Waist circumference	2.000000e-06
GCST009665_14	Breast cancer	8.000000e-07
GCST010701_111	Cortical surface area (MOSTest)	8.000000e-12
GCST010702_47	Subcortical volume (MOSTest)	6.000000e-10
GCST010703_329	Brain morphology (MOSTest)	2.000000e-10
GCST011154_4	Fasting plasma glucose	1.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	7
trichostatin A	decreases expression, affects cotreatment	3
sodium arsenite	decreases expression, increases expression	3
Tobacco Smoke Pollution	increases expression	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	decreases phosphorylation	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, affects expression, increases abundance	1
coumarin	affects phosphorylation	1
methacrylaldehyde	affects cotreatment, affects expression, increases abundance	1
perfluoro-n-nonanoic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
perfluorohexanesulfonic acid	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Acrolein	affects cotreatment, affects expression, increases abundance	1
Air Pollutants	affects cotreatment, affects expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	increases abundance, affects cotreatment, affects expression	1
Thimerosal	increases expression	1
Tretinoin	decreases expression	1
Triiodothyronine	decreases expression	1
Cyclosporine	increases methylation	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.