MIF-AS1

Summary

MIF-AS1 (MIF antisense RNA 1, HGNC:27669) is a long non-coding RNA gene on chromosome 22q11.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27669
Approved symbol	MIF-AS1
Name	MIF antisense RNA 1
Location	22q11.23
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC284889, MIF-AS
Ensembl gene	ENSG00000218537
Ensembl biotype	lncRNA
Entrez	284889
RNAcentral	URS000075D01B — lncRNA, 2192 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000406213

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000406213 — 3 exons

Exon	Start	End
ENSE00001548415	23894426	23895532
ENSE00001557423	23898844	23898930
ENSE00001562568	23895829	23896110

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 81.24.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.24	gold quality
bone marrow cell	CL:0002092	80.48	gold quality
superior frontal gyrus	UBERON:0002661	74.65	gold quality
mucosa of stomach	UBERON:0001199	73.31	gold quality
stromal cell of endometrium	CL:0002255	73.02	gold quality
cortical plate	UBERON:0005343	72.16	gold quality
granulocyte	CL:0000094	72.00	gold quality
liver	UBERON:0002107	71.91	gold quality
cortex of kidney	UBERON:0001225	71.82	gold quality
primary visual cortex	UBERON:0002436	71.68	gold quality
prefrontal cortex	UBERON:0000451	71.57	gold quality
ventricular zone	UBERON:0003053	70.93	gold quality
right testis	UBERON:0004534	70.78	gold quality
testis	UBERON:0000473	70.69	gold quality
left testis	UBERON:0004533	70.65	gold quality
ganglionic eminence	UBERON:0004023	70.47	gold quality
left uterine tube	UBERON:0001303	70.08	gold quality
sural nerve	UBERON:0015488	69.48	gold quality
right coronary artery	UBERON:0001625	68.79	gold quality
apex of heart	UBERON:0002098	68.78	gold quality
descending thoracic aorta	UBERON:0002345	68.61	gold quality
right lobe of liver	UBERON:0001114	68.47	gold quality
right uterine tube	UBERON:0001302	68.47	gold quality
mucosa of transverse colon	UBERON:0004991	68.12	gold quality
duodenum	UBERON:0002114	68.07	gold quality
transverse colon	UBERON:0001157	67.24	gold quality
cerebellum	UBERON:0002037	66.83	gold quality
body of stomach	UBERON:0001161	66.78	gold quality
ectocervix	UBERON:0012249	66.77	gold quality
left adrenal gland cortex	UBERON:0035825	66.68	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	15702.71
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• It is the first study, which shows that the allele A (rs34383331T > A) in ncRNA is significantly associated with increased risk to Plasmodium falciparum malaria. (PMID:24066864)
• the MIF-AS rs755622 polymorphism may have a crucial role in the development of nephrolithiasis. (PMID:26895959)
• Study shows that long non-coding RNA MIF-AS1 is upregulated and associated with oxidative phosphorylation pathway in gastric cancer. Its tumor-promoting role in gastric cancer was mainly dependent on positive regulation of NDUFA4. (PMID:30238562)
• Correlation of MIF-AS1 polymorphisms with the risk and prognosis of gastric cancer. (PMID:35367937)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.