MILIP

Summary

MILIP (MYC inducible lncRNA inactivating p53, HGNC:43649) is a long non-coding RNA gene on chromosome 17q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43649
Approved symbol	MILIP
Name	MYC inducible lncRNA inactivating p53
Location	17q25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000265688
Ensembl biotype	lncRNA
OMIM	621176
Entrez	92659
RNAcentral	URS000075B20D — lncRNA, 1914 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000582106

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582106 — 2 exons

Exon	Start	End
ENSE00002690534	81929476	81930753
ENSE00002713444	81927829	81928445

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 79.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.8218 / max 54.1666, expressed in 1394 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163383	2.3109	1158
208458	1.5108	866

Top tissues by expression

230 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.53	gold quality
secondary oocyte	CL:0000655	78.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.92	gold quality
oocyte	CL:0000023	74.84	silver quality
stromal cell of endometrium	CL:0002255	74.62	gold quality
cortical plate	UBERON:0005343	72.73	gold quality
adenohypophysis	UBERON:0002196	72.48	gold quality
ventricular zone	UBERON:0003053	72.27	gold quality
parotid gland	UBERON:0001831	71.96	gold quality
buccal mucosa cell	CL:0002336	71.68	gold quality
pituitary gland	UBERON:0000007	71.51	gold quality
right testis	UBERON:0004534	70.12	gold quality
left testis	UBERON:0004533	70.07	gold quality
right uterine tube	UBERON:0001302	68.77	gold quality
testis	UBERON:0000473	68.63	gold quality
ganglionic eminence	UBERON:0004023	66.56	gold quality
bronchial epithelial cell	CL:0002328	65.89	silver quality
bronchus	UBERON:0002185	65.38	silver quality
lower esophagus mucosa	UBERON:0035834	64.83	gold quality
tendon of biceps brachii	UBERON:0008188	64.19	gold quality
nucleus accumbens	UBERON:0001882	63.90	gold quality
esophagus mucosa	UBERON:0002469	63.75	gold quality
prefrontal cortex	UBERON:0000451	63.69	gold quality
cartilage tissue	UBERON:0002418	63.68	gold quality
left uterine tube	UBERON:0001303	63.45	gold quality
body of pancreas	UBERON:0001150	62.57	gold quality
right lobe of thyroid gland	UBERON:0001119	62.55	gold quality
anterior cingulate cortex	UBERON:0009835	62.48	gold quality
caudate nucleus	UBERON:0001873	62.44	gold quality
ectocervix	UBERON:0012249	62.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• suggested that MAFG-AS1 functions as a novel oncogenic lncRNA in the development of CRC by regulating miR-147b/NDUFA4 (PMID:30348529)
• LncRNA MAFG-AS1 promotes the aggressiveness of breast carcinoma through regulating miR-339-5p/MMP15. (PMID:31002134)
• LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis (PMID:31211984)
• MAFG-AS1 is a novel clinical biomarker for clinical progression and unfavorable prognosis in gastric cancer. (PMID:32079456)
• Long noncoding RNA MAFG-AS1 facilitates the progression of hepatocellular carcinoma via targeting miR-3196/OTX1 axis. (PMID:33336731)
• Regulatory effect of the MAFGAS1/miR1505p/MYB axis on the proliferation and migration of breast cancer cells. (PMID:33367930)
• LncRNA MAFG-AS1 regulates miR-125b-5p/SphK1 axis to promote the proliferation, migration, and invasion of bladder cancer cells. (PMID:33400245)
• LncRNA MAFG-AS1 affects the tumorigenesis of breast cancer cells via the miR-574-5p/SOD2 axis. (PMID:33989902)
• LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1. (PMID:34035482)
• LncRNA MAFG-AS1 deregulated in breast cancer affects autophagy and progression of breast cancer by interacting with miR-3612 and FKBP4 invitro. (PMID:35653827)
• LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma. (PMID:36028903)
• LncRNA MAFG-AS1-induced acute myeloid leukemia development via modulating miR-147b/HOXA9. (PMID:36229729)
• The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining. (PMID:36445966)
• MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis. (PMID:36654385)
• A review on the roles and molecular mechanisms of MAFG-AS1 in oncogenesis. (PMID:36736142)
• Long non-coding RNA MAFG-AS1: A promising therapeutic target for human cancers. (PMID:37105079)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.