MINCR

Summary

MINCR (MYC-induced long non-coding RNA, HGNC:51653) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51653
Approved symbol	MINCR
Name	MYC-induced long non-coding RNA
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00015189
Ensembl gene	ENSG00000253716
Ensembl biotype	lncRNA
Entrez	100507316
RNAcentral	URS000075CD64 — lncRNA, 696 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000517411, ENST00000518073, ENST00000519852, ENST00000521207, ENST00000523031, ENST00000524335, ENST00000691781, ENST00000773919, ENST00000773920, ENST00000773921, ENST00000773922, ENST00000773923, ENST00000773924

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517411 — 3 exons

Exon	Start	End
ENSE00002117809	143280882	143280997
ENSE00003986047	143281482	143281705
ENSE00004139409	143280147	143280515

Expression profiles

Bgee: expression breadth ubiquitous, 209 present calls, max score 91.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.6415 / max 65.7214, expressed in 1762 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95456	9.6625	1739
95455	0.7221	402
95454	0.2569	115

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.24	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.47	gold quality
right uterine tube	UBERON:0001302	85.73	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.93	gold quality
spinal cord	UBERON:0002240	84.49	gold quality
body of pancreas	UBERON:0001150	84.40	gold quality
left adrenal gland cortex	UBERON:0035825	84.38	gold quality
putamen	UBERON:0001874	84.20	gold quality
muscle of leg	UBERON:0001383	84.02	gold quality
gastrocnemius	UBERON:0001388	83.77	gold quality
left adrenal gland	UBERON:0001234	83.35	gold quality
nucleus accumbens	UBERON:0001882	83.12	gold quality
right adrenal gland	UBERON:0001233	83.01	gold quality
sural nerve	UBERON:0015488	83.01	gold quality
amygdala	UBERON:0001876	82.96	gold quality
skin of abdomen	UBERON:0001416	82.90	gold quality
apex of heart	UBERON:0002098	82.71	gold quality
body of stomach	UBERON:0001161	82.63	gold quality
mucosa of transverse colon	UBERON:0004991	82.63	gold quality
adrenal cortex	UBERON:0001235	82.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.48	gold quality
tibialis anterior	UBERON:0001385	82.40	silver quality
left ovary	UBERON:0002119	82.33	gold quality
caudate nucleus	UBERON:0001873	82.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.26	gold quality
skin of leg	UBERON:0001511	82.11	gold quality
left lobe of thyroid gland	UBERON:0001120	81.95	gold quality
anterior cingulate cortex	UBERON:0009835	81.94	gold quality
adenohypophysis	UBERON:0002196	81.86	gold quality
right adrenal gland cortex	UBERON:0035827	81.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• MINCR is a newly identified player in the MYC transcriptional network able to control the expression of cell cycle genes (PMID:26351698)
• LncRNA MINCR might stimulate the expression of EZH2 in gallbladder cancer cells, promoting tumor proliferation, invasion, and metastasis. (PMID:27345740)
• Our results showed that MINCR is important in hepatocellular carcinoma (HCC) development and may act as a therapeutic target that regulates HCC cellular proliferation, migration, and invasion, which are involved in HCC tumorigenesis (PMID:29550632)
• Dysfunction of MINCR, miR-126 and SLC7A5 predicted poor prognosis of patients with non-small cell lung cancer. (PMID:30528230)
• MINCR overexpression in hepatocellular carcinoma tissues correlates with clinicopathological disease progression and poor prognosis. (PMID:30556858)
• our findings revealed that MINCR may be an oncogene in oral squamous cell carcinoma via modulation of Wnt/beta-catenin pathway. (PMID:30777615)
• Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma (PMID:30947664)
• MINCR exerted inhibitory effects on the cell cycle arrest and apoptosis of non-small cell lung cancer cells. (PMID:31481083)
• Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression. (PMID:32333234)
• LncRNA MINCR promotes the development of liver cancer by regulating microRNA-107/beta-catenin. (PMID:32521894)
• Long non-coding RNA MINCR aggravates colon cancer via regulating miR-708-5p-mediated Wnt/beta-catenin pathway. (PMID:32535381)
• Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/beta-catenin signaling pathway. (PMID:35767742)
• A review on the role of MYC-induced long non-coding RNA in human disorders. (PMID:37285737)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.