MIR1-1

Summary

MIR1-1 (microRNA 1-1, HGNC:31499) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406904 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31499
Approved symbol	MIR1-1
Name	microRNA 1-1
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1-1
Ensembl gene	ENSG00000199017
Ensembl biotype	miRNA
OMIM	609326
Entrez	406904
RNAcentral	URS000075CF56 — miRNA, 71 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362147

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362147 — 1 exons

Exon	Start	End
ENSE00001436910	62554306	62554376

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 96.65.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	96.65	gold quality
blood	UBERON:0000178	91.95	gold quality
muscle of leg	UBERON:0001383	84.64	gold quality
adrenal tissue	UBERON:0018303	77.66	gold quality
gastrocnemius	UBERON:0001388	77.35	gold quality
monocyte	CL:0000576	75.33	gold quality
heart	UBERON:0000948	74.93	gold quality
right atrium auricular region	UBERON:0006631	74.41	gold quality
heart left ventricle	UBERON:0002084	73.84	gold quality
smooth muscle tissue	UBERON:0001135	72.73	gold quality
stomach	UBERON:0000945	71.59	gold quality
colon	UBERON:0001155	70.09	gold quality
ascending aorta	UBERON:0001496	68.95	gold quality
body of stomach	UBERON:0001161	68.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.52	gold quality
myometrium	UBERON:0001296	67.66	gold quality
fundus of stomach	UBERON:0001160	67.09	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.20	gold quality
granulocyte	CL:0000094	66.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.06	gold quality
urinary bladder	UBERON:0001255	65.67	gold quality
transverse colon	UBERON:0001157	65.62	gold quality
tibial artery	UBERON:0007610	65.62	gold quality
esophagus mucosa	UBERON:0002469	65.16	gold quality
thoracic mammary gland	UBERON:0005200	64.52	gold quality
left ovary	UBERON:0002119	64.23	gold quality
minor salivary gland	UBERON:0001830	63.19	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MEF2A, MYOD1, SRF

Literature-anchored findings (GeneRIF, showing 40)

• Reactivation of fetal microRNA contributes to alterations of gene expression in the failing human heart. (PMID:17606841)
• these results revealed that circulating miR-1 may be a novel, independent biomarker for diagnosis of acute myocardial infarction. (PMID:19896465)
• miRNA-1 may have a functional effect on chordoma tumor pathogenesis. (PMID:20041488)
• miR-1 showed dysregulation in myocardial infarction or fetal hearts when compared to healthy adults. (PMID:20075508)
• These findings suggest a role of miR-1 in the negative feedback loop in the regulation of smooth muscle contractility induced by myocardin. (PMID:20458751)
• Data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in bladder cancer (BC). (PMID:20843712)
• miR-1 was found to be involved in the regulation of the chondrocytic phenotype and thus to play an important role in chondrocytes during the late stage of the differentiation process, maintaining the integrity of the cartilage tissue. (PMID:20937250)
• Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. (PMID:21051663)
• Serum levels of miRNA (miR)-1 and miR-133a were increased significantly in CVD patients not only with acute myocardial infarction but also with unstable angina pectoris and Takotsubo cardiomyopathy (PMID:21642241)
• Results describe the profile of miR-1, miR-133a, miR-133b and miR-206 in human muscle cells isolated during different stages of fetal development. (PMID:21645416)
• miR-1 processing is altered in heart samples from people with myotonic dystrophy. (PMID:21685920)
• These results indicate the involvement of miR-1 in thyroid cell proliferation and migration, validating a role of miR-1 down-regulation in thyroid carcinogenesis. (PMID:21752897)
• Downregulation of the activity of the MRTF-SRF axis and the expression of muscle-specific microRNAs, particularly miR-1, may contribute to COPD-associated skeletal muscle dysfunction. (PMID:21998125)
• MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. (PMID:22059741)
• The PTMA is one of miR-1 target genes which involve in miR-1 inducing apoptosis. (PMID:22059741)
• Transfection of miR-1 into cell lines which express low levels of endogenous miR-1 will induce apoptosis. (PMID:22059741)
• these data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in bladder cancer. (PMID:22178073)
• Findings indicate that miR-1 acts as a tumor suppressor in prostate cancer by influencing multiple cancer-related processes and by inhibiting cell proliferation and motility. (PMID:22210864)
• Aberrant expression and functional significance ofthe miR-1/miR-133a and miR-206/miR-133b clusters in human cancers. (PMID:22308266)
• SLUG and miR-1/miR-200 act in a self-reinforcing regulatory loop, leading to amplification of epithelial-mesenchymal transition (PMID:22370643)
• Data suggest that miRNA-1 inhibits endogenous ET1 gene expression at post-transcriptional level in heart and other tissues. Studies include prediction of miRNA-1 binding site in 3’ untranslated region of ET1 gene. (PMID:22569256)
• DNA methylation regulates the expression of the miR-1-1 and miR-133a-2 cluster in colorectal cancer cell lines (PMID:22766685)
• IGF-1 inhibits H(2)O(2)-induced mitochondrial dysfunction, cytochrome-c release and apoptosis. IGF-1’s effect is, at least partially, regulated by miR-1 in induced pluripotent stem cells. (PMID:22982320)
• Elevated plasma microRNA-1 predicts heart failure after acute myocardial infarction. (PMID:23079087)
• Re-expression of miR-1 may be an effective therapy that prevents cancer malignancy by converting cells from a mesenchymal phenotype to an epithelial phenotype via the downregulation of Slug. (PMID:23142026)
• Our data assessed specific miRNA profiling deregulation in OS clinical samples and suggest that the expression of miR-1 and miR-133b may control cell proliferation and cell cycle through MET protein expression modulation. (PMID:23229283)
• Both miR-1-1 and (miR-181c) are associated with the pathogenesis of ventricular septal defects. (PMID:23352489)
• miR-1 attenuated LXRalpha-induced lipogenesis by targeting the 3’-UTR of LXRalpha mRNA. (PMID:23499676)
• MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells (PMID:23625462)
• Serum and urine MIR1 levels are significantly elevated following intraoperative cardiac injury. (PMID:23630629)
• Our study has now found miR-1 to be one of these MPM-associated microRNAs, with potential pathogenic and therapeutic significance. (PMID:23828229)
• Data show that microRNA-1 (miR-1) is down-regulated in colorectal tumors and that miR-1 has the potential to suppress NOTCH3 expression through direct binding to its 3’-UTR region. (PMID:24244701)
• miRNA-1 and miRNA-16 are important master regulators of miRNA-mediated regulation in prostate cancer. (PMID:24391925)
• miR-1 may play an important role in the pathogenesis of NSCLC by regulating PIK3CA through the PI3K/Akt pathway. (PMID:24486107)
• findings show suppressed miR-1 expression in chordoma may in part be a driver for tumor growth (PMID:24501096)
• Ectopic expression of micro-RNA-1, 21 and 125a in peripheral blood immune cells is associated with chronic hepatitis B infection. (PMID:24737570)
• findings indicate that sequence variants of miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2 are not a cause of LQTS in this cohort (PMID:24809446)
• In this review, we highlight recent findings on the aberrant expression and functional significance of miR-1 in human cancers and emphasize its significant values for therapeutic potentials. (PMID:24949449)
• Suggest that miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer. (PMID:24966896)
• miR-1 is significantly reduced in recurrent prostate cancer specimens in comparison to non-recurrent PCa samples. (PMID:24967583)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir1-1	ENSDARG00000088322
mus_musculus	Mir1a-1	ENSMUSG00000070144
rattus_norvegicus	Mir1b	ENSRNOG00000057048
drosophila_melanogaster	mir-1	FBGN0262455
caenorhabditis_elegans	cel-mir-1	WBGENE00003260

Paralogs (2): MIR206 (ENSG00000207604), MIR1-2 (ENSG00000284453)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.