MIR1-2

Summary

MIR1-2 (microRNA 1-2, HGNC:31500) is a microRNA gene on chromosome 18q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406905 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31500
Approved symbol	MIR1-2
Name	microRNA 1-2
Location	18q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1-2
Ensembl gene	ENSG00000284453
Ensembl biotype	miRNA
OMIM	610252
Entrez	406905
RNAcentral	URS0000447557 — miRNA, 85 nt, 57 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384961

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384961 — 1 exons

Exon	Start	End
ENSE00001499968	21829004	21829088

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 80.67.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	80.67	gold quality
body of stomach	UBERON:0001161	65.75	gold quality
heart left ventricle	UBERON:0002084	64.48	gold quality
gastrocnemius	UBERON:0001388	63.29	gold quality
transverse colon	UBERON:0001157	62.38	gold quality
skin of abdomen	UBERON:0001416	62.00	gold quality
tibial nerve	UBERON:0001323	61.11	gold quality
minor salivary gland	UBERON:0001830	61.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.65	gold quality
left lobe of thyroid gland	UBERON:0001120	58.32	gold quality
omental fat pad	UBERON:0010414	58.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	49.91	gold quality
spleen	UBERON:0002106	46.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• EVI1 controls proliferation in acute myeloid leukemia through modulation of miR-1-2. (PMID:20842122)
• miR-1 processing is altered in heart samples from people with myotonic dystrophy. (PMID:21685920)
• The PTMA is one of miR-1 target genes which involve in miR-1 inducing apoptosis. (PMID:22059741)
• Transfection of miR-1 into cell lines which express low levels of endogenous miR-1 will induce apoptosis. (PMID:22059741)
• Serum and urine MIR1 levels are significantly elevated following intraoperative cardiac injury. (PMID:23630629)
• Loss of NRF2 decreased the expression of the redox-sensitive histone deacetylase, HDAC4, resulting in increased expression of miR-1 and miR-206. (PMID:23921124)
• miR-1 may play an important role in the pathogenesis of NSCLC by regulating PIK3CA through the PI3K/Akt pathway. (PMID:24486107)
• findings show suppressed miR-1 expression in chordoma may in part be a driver for tumor growth (PMID:24501096)
• Suggest that miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer. (PMID:24966896)
• Results show that miR-1 is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 were overexpressed suggesting that MiR-1 plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31. (PMID:24969180)
• This study provides evidence for hsa-miR-1 to play tumor suppressive roles via downregulating lncRNA UCA1 in bladder cancer (PMID:25015192)
• Suggest circulating miR-1, miR-133a, and miR-206 as potential biomarkers of muscle damage or adaptation to exercise. (PMID:25146754)
• The review discusses the downregulation of microRNA-1 in various types of cardiac diseases and show its functional significance. (PMID:25177824)
• Results identify and characterize a new role for miR425, miR1, miR125, and miR150 in promoting radioresistance in glioblastomas. (PMID:25256711)
• MIR1 controls cell proliferation, apoptosis cell migration and invasiveness of hepatocellular carcinoma tumor endothelial cells. (PMID:26019452)
• Report potential value of miR-1 and miR-374b as biomarkers for colorectal cancer at different stages. (PMID:26045793)
• Data indicate that the relative expression of microRNAs miR-1, miR-208b, and miR-499a in the acute myocardial infarction (AMI) samples was 0.73-fold (a 1.4-fold decrease), 1.2-fold, and 0.48-fold (a 2.1-fold decrease), respectively. (PMID:26046358)
• These findings suggest that abnormal miR-1 expression is associated with an aggressive phenotype of breast carcinoma (PMID:26331797)
• MALAT1 regulates cancer stem cell activity and radioresistance by modulating the miR-1/slug axis. (PMID:26482776)
• miR-1 down-regulates breast cancer stem cell stemness, proliferation and migration by targeting the Frizzled 7 and TNKS2 to inhibit the Wnt/beta-catenin signaling. (PMID:26497855)
• plasma miR-1, miR-208 and miR-499 were demonstrated to be potential biomarkers for the prediction of acute myocardial infarction (PMID:26526403)
• low miR-1 expression is associated with shortened survival time in hepastocellular carcinoma (HCC); MiR-1 may act as a potential prognostic biomarker for HCC patients (PMID:26554254)
• miRNA-1 is involved in the occurrence of arrhythmia in many myocardial pathological conditions by post-transcriptionally regulating a variety of ion channels and proteins related to cardiac electrical activity. (PMID:26671473)
• Results show loss of miR-1 and miR-214 expression and high expression of their target gene, PIM1, in malignant mesothelioma suggesting a role in carcinogenesis of mesothelioma. (PMID:26820394)
• miR-1 bound both MALAT1 and cdc42 3’UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42. (PMID:26926567)
• Data suggest that miR-19b contributes to irregular beating through regulation of GJA1 by cooperating with miR-1 which could indicate that miR-19b and miR-1 might be critically involved in cardiac arrhythmia associated with viral myocarditis. (PMID:27213338)
• miR-1 suppresses vestibular schwannoma growth by targeting VEGFA, and should be considered as a potential therapeutic target for treatment of this condition. (PMID:27819721)
• The expression levels of the TNF-alpha, IL-18 and cTnI and the expression levels of the miR-1 and miR-146b could be used to predict viral myocarditis among children. (PMID:27997912)
• Results show that circulating MIR-1 increased during doxorubicin treatment which resulted in induced cardiotoxicity. (PMID:28052002)
• The aim of this study was to evaluate the levels of circulating miRNAs (miR-1, -23a, and -26a) that can be involved in postoperative atrial fibrillation. (PMID:28422282)
• miR-1 is downregulated in ovarian cancer tissues, and may play a tumor suppressive role by inhibiting c-Met expression and its effects on the regulation of cell proliferation, migration and invasion (PMID:28698064)
• miR-1 serves as a suppressor of Src in esophageal cancer cells, suppressing proliferation and promoting apoptosis. (PMID:29034995)
• High Hsp70 and Hsp90 expression was associated with worse overall survival and disease-free survival [review and meta-analysis] (PMID:29491084)
• Results show that miR1 is downregulated in pituitary tumor tissues and associated with a poor prognosis. Its overexpression suppresses the proliferation and induces the apoptosis of pituitary cancer cells. miR1 targets G6PD to suppress the NADPH production and glycolysis of pituitary cancer cells. (PMID:30272333)
• MiR-1-3p inhibited the bladder cancer cell proliferation, migration, and invasion by directly targeting the 3’-UTR of glutaminase. It also exerted an anti-tumor effect by negatively regulating the glutaminase in a xenograft mouse model. (PMID:30458442)
• Circulating microRNA-1 might diagnose early acute myocardial infarction and predict the prognosis of patients with chest pain. (PMID:30611212)
• Long noncoding RNA RMRP promotes proliferation and invasion via targeting miR-1-3p in non-small-cell lung cancer. (PMID:31050363)
• Data show that miR-1 is tumor suppressive miRNA in glioblastoma (GBM). miR-1 is expressed at relatively low levels in GBM, and high miR-1 expression is associated with better patient survival in glioma. Its ectopic expression in GBM cells inhibited cell proliferation and migration. Expression of miR-1 in GBM cell lines directly targets fibronectin. (PMID:31491450)
• ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation. (PMID:31782884)
• the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous Tre-2/Bub2/CDC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. (PMID:31799933)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir1-2	ENSDARG00000103352
mus_musculus	Mir1a-2	ENSMUSG00000106348
drosophila_melanogaster	mir-1	FBGN0262455
caenorhabditis_elegans	cel-mir-1	WBGENE00003260

Paralogs (2): MIR1-1 (ENSG00000199017), MIR206 (ENSG00000207604)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.