MIR100HG

Summary

MIR100HG (mir-100-let-7a-2-mir-125b-1 cluster host gene, HGNC:39522) is a long non-coding RNA gene on chromosome 11q24.1.

This gene produces long non-coding RNAs that act as regulators of cell proliferation. Alternative promoter usage and splicing results in multiple transcript variants. Some transcript variants may promote growth, while others may act to negatively regulate cell division.

Source: NCBI Gene 399959 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39522
Approved symbol	MIR100HG
Name	mir-100-let-7a-2-mir-125b-1 cluster host gene
Location	11q24.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	AGD1, lncRNA-N2, linc-NeD125
Ensembl gene	ENSG00000255248
Ensembl biotype	lncRNA
OMIM	615965
Entrez	399959
RNAcentral	URS0000A76E00 — lncRNA, 3129 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 246 — 246 lncRNA

ENST00000524376, ENST00000526674, ENST00000527100, ENST00000527474, ENST00000528381, ENST00000528986, ENST00000529733, ENST00000529804, ENST00000529823, ENST00000530072, ENST00000530955, ENST00000531071, ENST00000531381, ENST00000531470, ENST00000531629, ENST00000532315, ENST00000532319, ENST00000532350, ENST00000532890, ENST00000533109, ENST00000534195, ENST00000534297, ENST00000534782, ENST00000636654, ENST00000637700, ENST00000647591, ENST00000647749, ENST00000647967, ENST00000648082, ENST00000648084, ENST00000648163, ENST00000648209, ENST00000648213, ENST00000648576, ENST00000648734, ENST00000649216, ENST00000649293, ENST00000649544, ENST00000649626, ENST00000650497, ENST00000653167, ENST00000653565, ENST00000654519, ENST00000654571, ENST00000654629, ENST00000655138, ENST00000655232, ENST00000655288, ENST00000655814, ENST00000656226, ENST00000656387, ENST00000656682, ENST00000656793, ENST00000656868, ENST00000657554, ENST00000657990, ENST00000658183, ENST00000658364, ENST00000658452, ENST00000659296, ENST00000659378, ENST00000660148, ENST00000660311, ENST00000660329, ENST00000660603, ENST00000661432, ENST00000661695, ENST00000661848, ENST00000662950, ENST00000663296, ENST00000663802, ENST00000664908, ENST00000665051, ENST00000665305, ENST00000665519, ENST00000665673, ENST00000666085, ENST00000666347, ENST00000666485, ENST00000667484, ENST00000668776, ENST00000669306, ENST00000669472, ENST00000669993, ENST00000670198, ENST00000670374, ENST00000670396, ENST00000670520, ENST00000670843, ENST00000670951, ENST00000686059, ENST00000686772, ENST00000688615, ENST00000689894, ENST00000690059, ENST00000690151, ENST00000690198, ENST00000690515, ENST00000691884, ENST00000692610, ENST00000693154, ENST00000701811, ENST00000701835, ENST00000702205, ENST00000702309, ENST00000702516, ENST00000702652, ENST00000702800, ENST00000763196, ENST00000780376, ENST00000780377, ENST00000780378, ENST00000780379, ENST00000780380, ENST00000780381, ENST00000780382, ENST00000780383, ENST00000780384, ENST00000780385, ENST00000780386, ENST00000780387, ENST00000780388, ENST00000780389, ENST00000780390, ENST00000780391, ENST00000780392, ENST00000780393, ENST00000780394, ENST00000780395, ENST00000780396, ENST00000780397, ENST00000780398, ENST00000780399, ENST00000780400, ENST00000780401, ENST00000780402, ENST00000780403, ENST00000780404, ENST00000780405, ENST00000780406, ENST00000780407, ENST00000780408, ENST00000780409, ENST00000780410, ENST00000780411, ENST00000780412, ENST00000780413, ENST00000780414, ENST00000780415, ENST00000780416, ENST00000780417, ENST00000780418, ENST00000780419, ENST00000780420, ENST00000780421, ENST00000780422, ENST00000780423, ENST00000780424, ENST00000780425, ENST00000780426, ENST00000780427, ENST00000780428, ENST00000780429, ENST00000780430, ENST00000780431, ENST00000780432, ENST00000780433, ENST00000780434, ENST00000780435, ENST00000780436, ENST00000780437, ENST00000780438, ENST00000780439, ENST00000780440, ENST00000780441, ENST00000780442, ENST00000780443, ENST00000780444, ENST00000780445, ENST00000780446, ENST00000780447, ENST00000780448, ENST00000780449, ENST00000780450, ENST00000780451, ENST00000780452, ENST00000780453, ENST00000780454, ENST00000780455, ENST00000780456, ENST00000780457, ENST00000780458, ENST00000780459, ENST00000780460, ENST00000780461, ENST00000780462, ENST00000780463, ENST00000780464, ENST00000780465, ENST00000780466, ENST00000780467, ENST00000780468, ENST00000780469, ENST00000780470, ENST00000780471, ENST00000780472, ENST00000780473, ENST00000780474, ENST00000780475, ENST00000780476, ENST00000780477, ENST00000780478, ENST00000780479, ENST00000780480, ENST00000780481, ENST00000780482, ENST00000780483, ENST00000780484, ENST00000780485, ENST00000780486, ENST00000780487, ENST00000780488, ENST00000780489, ENST00000780490, ENST00000780491, ENST00000780492, ENST00000780493, ENST00000780494, ENST00000780495, ENST00000780496, ENST00000780497, ENST00000780498, ENST00000780499, ENST00000780500, ENST00000780501, ENST00000780502, ENST00000780503, ENST00000780504, ENST00000780505, ENST00000780506, ENST00000780507, ENST00000780508, ENST00000780509, ENST00000780510, ENST00000780511, ENST00000780512

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000524376 — 2 exons

Exon	Start	End
ENSE00002200195	122089103	122091719
ENSE00004151827	122100374	122100501

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 99.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 59.7702 / max 1464.0687, expressed in 1231 samples.

FANTOM5 promoters (50 alternative TSS)

Promoter ID	TPM avg	Samples expressed
122811	23.7529	1006
122819	4.3189	636
122812	3.0949	845
122849	2.7556	597
122814	2.6721	692
122820	2.5387	546
122843	2.5174	513
122847	1.6853	524
122853	1.4695	559
122846	1.4493	544

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	99.08	gold quality
ganglionic eminence	UBERON:0004023	98.95	gold quality
cartilage tissue	UBERON:0002418	98.90	gold quality
descending thoracic aorta	UBERON:0002345	98.36	gold quality
cortical plate	UBERON:0005343	98.32	gold quality
right coronary artery	UBERON:0001625	98.08	gold quality
ascending aorta	UBERON:0001496	98.05	gold quality
thoracic aorta	UBERON:0001515	98.04	gold quality
sural nerve	UBERON:0015488	97.69	gold quality
caput epididymis	UBERON:0004358	97.65	gold quality
left ovary	UBERON:0002119	97.52	gold quality
right ovary	UBERON:0002118	97.30	gold quality
stromal cell of endometrium	CL:0002255	97.16	gold quality
calcaneal tendon	UBERON:0003701	96.83	gold quality
right uterine tube	UBERON:0001302	96.55	gold quality
corpus epididymis	UBERON:0004359	96.54	gold quality
aorta	UBERON:0000947	96.34	gold quality
endocervix	UBERON:0000458	96.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.20	gold quality
coronary artery	UBERON:0001621	96.19	gold quality
left coronary artery	UBERON:0001626	96.17	gold quality
cardiac muscle of right atrium	UBERON:0003379	96.08	gold quality
left uterine tube	UBERON:0001303	96.06	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.02	gold quality
lower esophagus	UBERON:0013473	95.96	gold quality
ovary	UBERON:0000992	95.77	gold quality
nucleus accumbens	UBERON:0001882	95.58	gold quality
caudate nucleus	UBERON:0001873	95.32	gold quality
adenohypophysis	UBERON:0002196	95.30	gold quality
mucosa of stomach	UBERON:0001199	95.21	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	47.61
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Tag single nucleotide polymorphisms near the BLID and LOC399959 genes are not susceptibility loci for high myopia in the Chinese Han population. (PMID:21031016)
• This study reveals an unprecedented function of long non-coding RNAs MONC and MIR100HG as regulators of hematopoiesis and oncogenes in the development of myeloid leukemia. (PMID:25027842)
• Linc-NeD125 represents the host gene for miR-125b-1, a microRNA with an established role as negative regulator of human neuroblastoma cell proliferation. (PMID:26480000)
• TGF-beta induces MIR100HG lncRNA, encoding miR-100, let-7a and miR-125b that control pancreatic ductal adenocarcinoma tumorigenesis. Pro-tumorigenic miR-100 and miR-125b increase and anti-tumorigenic let-7a is unchanged, as TGF-beta also induces LIN28B. The induction of LIN28B results in the up-regulation of miR-100 and miR-125b, with let-7a unchanged despite being part of the same MIR100HG primary transcript. (PMID:29748571)
• MIR100HG rs1816158 was associated with overall survival in oral cavity cancer. Expression of miR-100 was associated with overall survival in an independent cohort of head and neck squamous cell carcinoma (HNSCC) cases. (PMID:29880533)
• MIR100HG formed a triplex structure with p27. Through regulating the expression of p27, MIR100HG promoted cell proliferation in TNBC. Increased expression of MIR100HG was associated with poor prognosis. (PMID:30042378)
• We conclude that MIR100HG potentially serves as a binding platform for both HuR and its target mRNAs, thus modulating HuR-target mRNA interaction (PMID:30102375)
• ELK1-induced up-regulation of MIR100HG promoted osteosarcoma progression by epigenetically silencing LATS1 and LATS2. (PMID:30551532)
• The study in vitro suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. In conclusion, MIR100HG is a credible prognostic biomarker and functions as an oncogenic lncRNA in gastric cancer. (PMID:30886062)
• Constitutive beta-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer. (PMID:35247921)
• Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression. (PMID:35279145)
• A concise review on the role of MIR100HG in human disorders. (PMID:37487022)
• LncRNA MIR100HG Promotes Cell Proliferation in Nasopharyngeal Carcinoma by Targeting miR-136-5p/IL-6 Axis. (PMID:38278928)
• LncRNA MIR100HG affects the proliferation and metastasis of lung cancer cells through mediating the microRNA-5590-3p/DCBLD2 axis. (PMID:38602284)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.