MIR103A1

Summary

MIR103A1 (microRNA 103a-1, HGNC:31490) is a microRNA gene on chromosome 5q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406895 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31490
Approved symbol	MIR103A1
Name	microRNA 103a-1
Location	5q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-103-1, hsa-mir-103a-1
Ensembl gene	ENSG00000199035
Ensembl biotype	miRNA
OMIM	613187
Entrez	406895
RNAcentral	URS0000561D92 — miRNA, 78 nt, 40 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362165

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362165 — 1 exons

Exon	Start	End
ENSE00001436928	168560896	168560973

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 80.11.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.11	gold quality
placenta	UBERON:0001987	78.42	gold quality
intestine	UBERON:0000160	74.57	gold quality
heart	UBERON:0000948	73.72	gold quality
omental fat pad	UBERON:0010414	68.22	gold quality
colon	UBERON:0001155	67.08	gold quality
skin of abdomen	UBERON:0001416	66.74	gold quality
left adrenal gland cortex	UBERON:0035825	65.44	gold quality
left ovary	UBERON:0002119	62.50	gold quality
left adrenal gland	UBERON:0001234	62.49	gold quality
prostate gland	UBERON:0002367	61.37	gold quality
skin of leg	UBERON:0001511	60.49	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.71	gold quality
hypothalamus	UBERON:0001898	59.31	gold quality
cerebellar hemisphere	UBERON:0002245	59.14	gold quality
corpus callosum	UBERON:0002336	48.05	silver quality
left testis	UBERON:0004533	40.07	gold quality
right testis	UBERON:0004534	38.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• microRNAs 103 and 107 repress translation of cofilin (PMID:21179570)
• The results of this pilot study show that miR-103 is characterized by a promising sensitivity and specificity and might be a potential minimally-invasive biomarker for the diagnosis of mesothelioma. (PMID:22253921)
• We aimed to evaluate the effects of sex, sex hormones, and polycystic ovary syndrome and their interactions with obesity on the expression in the circulation of these miRNAs. (PMID:24037889)
• MiR-103 significantly promotes cancer cell proliferation, invasion and metastasis, and, thus, could be an important mediator in the pathogenesis of colorectal cancer Through regulation of colorectal cancer cell DICER and PTEN expression. (PMID:24828205)
• The interaction of miR-103a-3p with each of the two 5’ UTR targets reduces the expression levels of both GPRC5A mRNA and GPRC5A protein in one normal epithelial and two pancreatic cancer cell lines. (PMID:24984703)
• miR-103a is the first identified mechanosensitive miRNA that regulates osteoblast differentiation by directly targeting Runx2 (PMID:25195535)
• We further confirmed that miR-103/107 inhibited P-gp function in gastric cancer SGC7901/ADR cells. Finally, we verified that caveolin-1 (Cav-1), a critical component of lipid rafts, was a target of miR-103/107 (PMID:25407491)
• miR-103 is involved in insulin resistance and NAFLD, and may be a molecular link between insulin resistance and NAFLD. (PMID:25593466)
• overexpression of miR-103a-3p, miR-30b-5p and miR-29a-3p in L-Dopa treated patients with Parkinson disease (PD) was observed; promising candidate target genes for these were revealed by in silico analysis; data provide a rationale for clarifying role of the miRNAs in the pathogenesis of PD (PMID:25596505)
• microRNA family (miRs-103/107) preferentially expressed in the stem cell-enriched limbal epithelium regulates and integrates these stem cell characteristics. (PMID:25639731)
• Our results provide an extensive genome wide set of targets for miR-503, miR-103, and miR-494, and suggest that miR-503 may act as a tumor suppressor in breast cancer by its direct non-canonical targeting of DDHD2. (PMID:25653011)
• Discrimination analysis using a combination of miR-100, miR-103 and miR-375 was able to detect Alzheimer’s disease in CSF by positively classifying controls and Alzheimer’s disease cases with 96.4%and 95.5%accuracy, respectively. (PMID:25992776)
• Results show differentially expressed miR34b and miR103a in Chinese patients with autism spectrum disorder (ASD) that may explain high incidence in males and the abnormal ubiquitin-mediated proteolysis in ASD patients respectively. (PMID:26061495)
• miR-103 is a proto-oncogene miRNA that can suppress Prostate cancer proliferation and migration by down-regulating the oncogene PDCD10. (PMID:26771762)
• Low miR103a expression is associated with bladder carcinoma. (PMID:27484176)
• MiR-103a might be a potential biomarker of myocardium infarction and could be used as an index for the diagnosis of AMI. It may be involved in the development of HBP and onset of AMI through regulating the Piezo1 expression. (PMID:27515482)
• High miR103a expression is associated with Coronary Artery Disease. (PMID:27629254)
• the plasma expression levels of miR-103a discriminated patients with stable graft function from patients with T-cell mediated rejection and from patients with urinary tract infection (PMID:27663089)
• miR-103/107 ensure proper end-stage autophagy by regulating diacylglycerol/protein kinase C and cyclin-dependent kinase 5 signaling, which enables dynamin to function in vacuole clearance. (PMID:27872138)
• miR-103 plays a pivotal role in glucocorticoids-induced apoptosis (GCIA) and that its upregulation sensitizes glucocorticoids resistant cells to GCIA. (PMID:27888798)
• In contrast to the DCKO mouse model, plasma miR-103, miR-107, and miR-194 levels are not altered in Diffuse-type gastric cancer (DGC) and are not suitable for human DGC screening (PMID:27909811)
• MiR-103 acts as an oncogene miRNA to promote triple-negative breast cancer cells migration and invasion through targeting OLFM4. (PMID:28320108)
• Upregulation of miR-103 might contribute to gastric cancer progression by suppressing KLF4 expression and subsequently promoting the proliferation, migration, and invasion, and inhibiting apoptosis of gastric cancer cells. (PMID:28445396)
• In the present study, we showed that miR-103 expression was reduced in NSCLC tissues and cells. miR-103 expression was negatively correlated with tumor size and stage. (PMID:28734041)
• MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting BDNF. (PMID:29257320)
• Expression levels of six reference microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed in plasma from vulvar intraepithelial neoplasia lesion and vulvar squamous cell carcinoma. (PMID:29299981)
• The combination of miR-24, miR-103a, and let-7a was identified as one of the most stable sets of endogenous reference genes for normalization in formalin-fixed, paraffin-embedded (FFPE) lymph node. This study may provide a basis for miRNA expression analysis in FFPE lymph node tissue (PMID:29651113)
• miR-103 programs endothelial cells toward a maladapted phenotype through targeting of lncWDR59, which may promote atherosclerosis. (PMID:29980665)
• Study results demonstrated that serum miR-103 was overexpressed in colorectal cancer (CRC) subjects, could differentiate CRC cases from controls with relatively high accuracy, and significantly correlated with worse clinical factors, as well as poorer recurrence-free survival or overall survival. Taken together, serum miR-103 might be a promising biomarker for diagnosis and prognosis of CRC. (PMID:30058684)
• Clinical data indicates that a high expression of miR103 is associated with the progression of hepatocellular carcinoma (HCC). Further results suggest that miR103 promotes HCC metastasis and EMT by directly inhibiting LATS2. (PMID:30272278)
• Mechanistically, the rs884225 C allele enhanced EGFR expression by altering the miR-103a-3p binding site, thus impairing miR-103a-3p’s anti-tumourigenic function. As a tumour suppressor gene, miR-103a-3p expression correlated with overall and recurrence-free survival in Non small cell lung carcinoma patients. rs884225 may be a biomarker for NSCLC susceptibility, and miR-103a-3p may be a potential therapeutic target. (PMID:30470824)
• Mir-103a target SVCT1 3’-UTR and regulates SVCT1 expression in the intestinal epithelial cells. (PMID:30616065)
• miR-103a-2-5p/miR-30c-1-3p inhibits the progression of prostate cancer resistance to androgen ablation therapy via targeting androgen receptor variant 7. (PMID:30963631)
• Study in hypertensive nephropathy patients and angiotensin II (AngII)-infused mice revealed that AngII increases circulating miR-103a-3p levels, which reduces SNRK levels in glomerular endothelial cells, resulting in the over-activation of NF-kappaB/p65 and, consequently, renal inflammation and fibrosis. (PMID:31086184)
• Overexpression of the long noncoding RNA TRHDE-AS1 inhibits the progression of lung cancer via the miRNA-103/KLF4 axis. (PMID:31119790)
• miR-103/107 prolong Wnt/beta-catenin signaling and colorectal cancer stemness by targeting Axin2. (PMID:31273221)
• microRNA-103 promotes LPS-induced inflammatory injury by targeting c-Myc in HK-2 cells (PMID:31284776)
• An investigation of microRNA-103 and microRNA-107 as potential blood-based biomarkers for disease risk and progression of Alzheimer’s disease. (PMID:31420923)
• miR-103a and miR-103b had high complementarity and conservation, modulated reporter gene expression through seed sequences in the 3’UTRs of CAV-1 and SFRP4 mRNA, and negatively regulated their mRNA and protein levels (PMID:31583475)
• Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. (PMID:31613419)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-103	ENSDARG00000081583
danio_rerio	mir107b	ENSDARG00000081704
danio_rerio	dre-mir-107	ENSDARG00000083423
mus_musculus	Mir103-1	ENSMUSG00000065553
rattus_norvegicus	Mir103a1	ENSRNOG00000035503

Paralogs (2): MIR107 (ENSG00000198997), MIR103A2 (ENSG00000199024)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.