MIR103A2

Summary

MIR103A2 (microRNA 103a-2, HGNC:31491) is a microRNA gene on chromosome 20p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406896 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31491
Approved symbol	MIR103A2
Name	microRNA 103a-2
Location	20p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-103-2, hsa-mir-103a-2
Ensembl gene	ENSG00000199024
Ensembl biotype	miRNA
OMIM	613188
Entrez	406896
RNAcentral	URS0000302909 — miRNA, 78 nt, 32 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362154

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362154 — 1 exons

Exon	Start	End
ENSE00001436917	3917494	3917571

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 98.74.

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.74	gold quality
buccal mucosa cell	CL:0002336	97.80	gold quality
monocyte	CL:0000576	89.95	gold quality
leukocyte	CL:0000738	89.52	gold quality
granulocyte	CL:0000094	89.29	gold quality
tendon of biceps brachii	UBERON:0008188	83.24	silver quality
oviduct epithelium	UBERON:0004804	83.21	gold quality
tendon	UBERON:0000043	81.76	gold quality
right coronary artery	UBERON:0001625	81.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.52	gold quality
rectum	UBERON:0001052	81.50	gold quality
anterior cingulate cortex	UBERON:0009835	81.50	gold quality
bone marrow	UBERON:0002371	81.04	gold quality
calcaneal tendon	UBERON:0003701	80.49	gold quality
smooth muscle tissue	UBERON:0001135	80.33	gold quality
adrenal tissue	UBERON:0018303	80.14	gold quality
epithelial cell of pancreas	CL:0000083	79.78	gold quality
muscle of leg	UBERON:0001383	79.67	gold quality
right frontal lobe	UBERON:0002810	79.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.92	gold quality
gastrocnemius	UBERON:0001388	78.91	gold quality
endothelial cell	CL:0000115	78.67	gold quality
islet of Langerhans	UBERON:0000006	78.11	gold quality
descending thoracic aorta	UBERON:0002345	78.06	gold quality
left adrenal gland cortex	UBERON:0035825	77.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.59	gold quality
cartilage tissue	UBERON:0002418	77.43	silver quality
thoracic aorta	UBERON:0001515	77.25	gold quality
tibial artery	UBERON:0007610	77.19	gold quality
popliteal artery	UBERON:0002250	77.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• MiR-103 significantly promotes cancer cell proliferation, invasion and metastasis, and, thus, could be an important mediator in the pathogenesis of colorectal cancer Through regulation of colorectal cancer cell DICER and PTEN expression. (PMID:24828205)
• The interaction of miR-103a-3p with each of the two 5’ UTR targets reduces the expression levels of both GPRC5A mRNA and GPRC5A protein in one normal epithelial and two pancreatic cancer cell lines. (PMID:24984703)
• miR-103 is involved in insulin resistance and NAFLD, and may be a molecular link between insulin resistance and NAFLD (PMID:25593466)
• overexpression of miR-103a-3p, miR-30b-5p and miR-29a-3p in L-Dopa treated patients with Parkinson disease (PD) was observed; promising candidate target genes for these were revealed by in silico analysis; data provide a rationale for clarifying role of the miRNAs in the pathogenesis of PD (PMID:25596505)
• Results show differentially expressed miR34b and miR103a in Chinese patients with autism spectrum disorder (ASD) that may explain high incidence in males and the abnormal ubiquitin-mediated proteolysis in ASD patients respectively. (PMID:26061495)
• Upregulation of miR-103 might contribute to gastric cancer progression by suppressing KLF4 expression and subsequently promoting the proliferation, migration, and invasion, and inhibiting apoptosis of gastric cancer cells. (PMID:28445396)
• In the present study, we showed that miR-103 expression was reduced in NSCLC tissues and cells. miR-103 expression was negatively correlated with tumor size and stage. (PMID:28734041)
• Circulating levels of miR-103a-3p (previously associated with myocardial necrosis in humans models) were downregulated immediately after acute exercise and remained decreased at the 24-hour sampling point. (PMID:29776561)
• Study results demonstrated that serum miR-103 was overexpressed in colorectal cancer (CRC) subjects, could differentiate CRC cases from controls with relatively high accuracy, and significantly correlated with worse clinical factors, as well as poorer recurrence-free survival or overall survival. Taken together, serum miR-103 might be a promising biomarker for diagnosis and prognosis of CRC. (PMID:30058684)
• Clinical data indicates that a high expression of miR103 is associated with the progression of hepatocellular carcinoma (HCC). Further results suggest that miR103 promotes HCC metastasis and EMT by directly inhibiting LATS2. (PMID:30272278)
• Mir-103a target SVCT1 3’-UTR and regulates SVCT1 expression in the intestinal epithelial cells. (PMID:30616065)
• miR-103a-2-5p/miR-30c-1-3p inhibits the progression of prostate cancer resistance to androgen ablation therapy via targeting androgen receptor variant 7. (PMID:30963631)
• Study in hypertensive nephropathy patients and angiotensin II (AngII)-infused mice revealed that AngII increases circulating miR-103a-3p levels, which reduces SNRK levels in glomerular endothelial cells, resulting in the over-activation of NF-kappaB/p65 and, consequently, renal inflammation and fibrosis. (PMID:31086184)
• miR-103/107 prolong Wnt/beta-catenin signaling and colorectal cancer stemness by targeting Axin2. (PMID:31273221)
• microRNA-103 promotes LPS-induced inflammatory injury by targeting c-Myc in HK-2 cells (PMID:31284776)
• An investigation of microRNA-103 and microRNA-107 as potential blood-based biomarkers for disease risk and progression of Alzheimer’s disease. (PMID:31420923)
• Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12. (PMID:31613419)
• Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1. (PMID:31645082)
• Exosomal miR-103a-3p ameliorates lipopolysaccharide-induced immune response in BEAS-2B cells via NF-kappaB pathway by targeting transducin beta-like 1X related protein 1. (PMID:31876003)
• hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression. (PMID:31962276)
• Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells. (PMID:32061112)
• MicroRNA-103 Protects Coronary Artery Endothelial Cells against H2O2-Induced Oxidative Stress via BNIP3-Mediated End-Stage Autophagy and Antipyroptosis Pathways. (PMID:32190178)
• MicroRNA103a3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma. (PMID:32467999)
• Tumor-derived exosomal miR-103a-2-5p facilitates esophageal squamous cell carcinoma cell proliferation and migration. (PMID:32572925)
• LINC00662 modulates cervical cancer cell proliferation, invasion, and apoptosis via sponging miR-103a-3p and upregulating PDK4. (PMID:33819358)
• Cancer-associated fibroblasts secreted miR-103a-3p suppresses apoptosis and promotes cisplatin resistance in non-small cell lung cancer. (PMID:33999859)
• Roles of miR-10a-5p and miR-103a-3p, Regulators of BDNF Expression in Follicular Fluid, in the Outcomes of IVF-ET. (PMID:34054723)
• MicroRNA-103a-3p Promotes Cell Proliferation and Invasion in Non-Small-Cell Lung Cancer Cells through Akt Pathway by Targeting PTEN. (PMID:34307670)
• Down-regulation of EVA1A by miR-103a-3p promotes hepatocellular carcinoma cells proliferation and migration. (PMID:36273122)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-103	ENSDARG00000081583
danio_rerio	mir107b	ENSDARG00000081704
danio_rerio	dre-mir-107	ENSDARG00000083423
mus_musculus	Mir103-2	ENSMUSG00000065563
rattus_norvegicus	Mir103a2	ENSRNOG00000035496

Paralogs (2): MIR107 (ENSG00000198997), MIR103A1 (ENSG00000199035)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.