MIR105-2

Summary

MIR105-2 (microRNA 105-2, HGNC:31493) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406898 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31493
Approved symbol	MIR105-2
Name	microRNA 105-2
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-105-2
Ensembl gene	ENSG00000207818
Ensembl biotype	miRNA
OMIM	300812
Entrez	406898
RNAcentral	URS0000638811 — miRNA, 81 nt, 33 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385083

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385083 — 1 exons

Exon	Start	End
ENSE00001808792	152394412	152394492

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 83.85.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.85	gold quality
right lobe of liver	UBERON:0001114	72.02	gold quality
gastrocnemius	UBERON:0001388	69.12	gold quality
body of stomach	UBERON:0001161	68.09	gold quality
esophagus mucosa	UBERON:0002469	64.99	gold quality
skin of abdomen	UBERON:0001416	61.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.17	gold quality
right uterine tube	UBERON:0001302	56.91	gold quality
testis	UBERON:0000473	41.87	gold quality
left testis	UBERON:0004533	39.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Data indicate CDK6 as a putative target of miR-105 which is likely a main contributor to the inhibition of tumour cell growth observed in our assays. (PMID:23950948)
• Data indicate that adult CD34(+) cells express endogenous miR-105 during megakaryocyte differentiation. (PMID:24446170)
• GABRA3 harbors a microRNA (miR-105), which has recently been identified as a promoter of cancer metastasis by its ability to weaken vascular endothelial barriers following exosomal secretion. (PMID:25089631)
• miR-105 promotes MYC-mediated metabolic reprogramming of breast cancer stromal cells, contributing to sustained tumour growth by conditioning the shared metabolic environment. (PMID:29662176)
• Up-regulation of miRNA-105 inhibits the progression of gastric carcinoma by directly targeting SOX9. (PMID:31115004)
• MiR-105 inhibits gastric cancer cells metastasis, epithelial-mesenchymal transition by targeting SOX9. (PMID:31364116)
• Higher level of miR-105-2 predicts poorer prognosis in esophageal cancer patients, and miR-105 can promote esophageal cancer cell proliferation, migration, and invasion. (PMID:31796663)
• Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis. (PMID:33345445)
• MiR-105-3p acts as an oncogene to promote the proliferation and metastasis of breast cancer cells by targeting GOLIM4. (PMID:33722196)
• MiR-105 enhances osteogenic differentiation of hADSCs via the targeted regulation of SOX9. (PMID:33838353)
• Role of hsamiR105 during the pathogenesis of paclitaxel resistance and its clinical implication in ovarian cancer. (PMID:33846814)
• Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1. (PMID:39103205)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir105	ENSMUSG00000077847

Paralogs (1): MIR105-1 (ENSG00000207957)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.