MIR107

Summary

MIR107 (microRNA 107, HGNC:31496) is a microRNA gene on chromosome 10q23.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406901 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31496
Approved symbol	MIR107
Name	microRNA 107
Location	10q23.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-107
Ensembl gene	ENSG00000198997
Ensembl biotype	miRNA
OMIM	613189
Entrez	406901
RNAcentral	URS000008F0CF — miRNA, 81 nt, 25 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362127

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362127 — 1 exons

Exon	Start	End
ENSE00001436890	89592747	89592827

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 78.99.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	78.99	gold quality
lung	UBERON:0002048	74.51	gold quality
right atrium auricular region	UBERON:0006631	73.76	gold quality
gastrocnemius	UBERON:0001388	72.54	gold quality
heart	UBERON:0000948	72.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.93	gold quality
right lobe of thyroid gland	UBERON:0001119	68.92	gold quality
heart left ventricle	UBERON:0002084	68.87	gold quality
liver	UBERON:0002107	68.74	gold quality
blood	UBERON:0000178	68.15	gold quality
stomach	UBERON:0000945	67.33	gold quality
transverse colon	UBERON:0001157	67.24	gold quality
body of stomach	UBERON:0001161	67.02	gold quality
right frontal lobe	UBERON:0002810	66.83	gold quality
frontal lobe	UBERON:0016525	66.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.43	gold quality
body of pancreas	UBERON:0001150	66.30	gold quality
intestine	UBERON:0000160	66.23	gold quality
endocervix	UBERON:0000458	65.93	gold quality
skin of abdomen	UBERON:0001416	65.88	gold quality
tibial artery	UBERON:0007610	65.84	gold quality
left coronary artery	UBERON:0001626	65.67	gold quality
esophagus mucosa	UBERON:0002469	65.40	gold quality
anterior cingulate cortex	UBERON:0009835	65.35	gold quality
left adrenal gland	UBERON:0001234	65.07	gold quality
vagina	UBERON:0000996	64.45	gold quality
tibial nerve	UBERON:0001323	64.18	gold quality
adult mammalian kidney	UBERON:0000082	63.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.66	gold quality
cerebellum	UBERON:0002037	63.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HNF1A

Literature-anchored findings (GeneRIF, showing 40)

• miR-107 gene expression is involved in accelerated Alzeimer’s disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). BACE1. (PMID:18234899)
• We identified new cell cycle regulating miRNAs, miR-107 and miR-185, localized in frequently altered chromosomal regions in human lung cancers (PMID:19688090)
• a significant regulation of PLAG1 by miR-181a, miR-181b, miR-107, and miR-424. (PMID:19692702)
• show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). (PMID:20308559)
• miR-107 expression tends to be lower relative to other miRNAs as Alzheimer’s disease progresses. (PMID:20413881)
• These findings indicate that miR-107 contributes to granulin expression regulation with implications for brain disorders. (PMID:20489155)
• Findings indicate that the mitogen and growth factor GRN is dysregulated via the miR-15/107 gene group in multiple human cancers, which may provide a potential common therapeutic target. (PMID:20884628)
• miR-107, an oncogene miRNA promoting gastric cancer metastasis through down-regulation of DICER1. (PMID:21029372)
• microRNAs 103 and 107 repress translation of cofilin (PMID:21179570)
• Loss of MIRN107 is associated with gastric cancer invasion. (PMID:21264532)
• findings indicate that miR-103 and miR-107 regulate CDK5R1 expression, allowing us to hypothesize that a miRNA-mediated mechanism may influence CDK5 activity and the associated molecular pathways (PMID:21625387)
• a mechanism for LPS signaling which involves a decrease in miR-107 leading to an increase in CDK6 (PMID:21628465)
• Data demonstrate that miR-107 negatively regulates the tumor suppressor miRNA let-7 via a direct interaction. (PMID:21841313)
• protein kinase C-epsilon is directly regulated by miR-107 in squamous cell carcinoma of the head and neck. (PMID:22158047)
• Our data indicate that overexpression of miR-107 in gastric cancer tissues has prognostic value. In the present study, we examined the relationship between miR-107 and DICER1 mRNA levels, and demonstrated a significant inverse correlation. (PMID:22407237)
• Here, we found that high expression of miR-103 and miR-107 (miR-103/107) was associated with metastasis potential of CRC cell lines and poor prognosis in patients with CRC (PMID:22593189)
• The translation efficiency (protein/mRNA ratio) for CYP2C8 was inversely correlated with the expression of miR-103 and miR-107. (PMID:22723340)
• Data suggest that miR-107 is overexpressed in pituitary adenomas and acts as a tumor suppressor; pituitary tumor suppressor gene AIP (aryl hydrocarbon receptor-interacting protein) is a miR-107 target gene; both may have roles in tumorigenesis. (PMID:22811466)
• p53-induced miR-107 suppresses brain tumor cell growth and down-regulates CDK6 and Notch-2 expression, supporting its tumor suppressor role and utility as a target for glioma therapy. (PMID:23220650)
• this study indicated that miR-107 is involved in glioma cell migration and invasion, and support its utility as a potential target for glioma treatment. (PMID:23299462)
• miR-107 levels regulate CHRM1 expression in schizophrenia, differentially contributing to its pathophysiology. (PMID:23423139)
• miR-107 is involved in U87 glioma stem cell growth and invasion and may provide a potential therapeutic target for glioma treatment. (PMID:23572380)
• results document that the miR-107 levels may discriminate esophageal squamous cell carcinoma patients from healthy individuals emphasizing its diagnostic potential (PMID:23627613)
• Results demonstrate upregulation of miR-107 suppressed glioma cell growth through direct targeting of SALL4. (PMID:23811124)
• both miR-103 and miR-107 directly target and regulate RAD51 and RAD51D; findings demonstrate a role for miR-103 and -107 in regulating DNA damage repair, identifying new players in the progression of cancer and response to chemotherapy (PMID:24088786)
• miR-107 is an important regulator in gastric cancer (PMID:24374340)
• Hepatitis C virus-induced changes in miRNA-449a and miRNA-107 regulate CCL2 expression by activation of the IL-6-mediated signaling cascade by targeting components of the interleukin-6 receptor complex. (PMID:24429361)
• Our results suggest that increased levels of miR-107 are critical in promoting lipid accumulation in hepatocytes and this might form the basis of diverse etiologies encountered in a fatty liver (PMID:24560669)
• MicroRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway or apparently distinct targets. miR-107 is found to be implicated in the pathogenesis of some diseases. [review] (PMID:24597825)
• miR-107 has a role in GLT-1 expression regulation. (PMID:24943094)
• Low expression of miR-107 was significantly associated with tumor progression and decreased survival in patients with non-small cell lung cancer (PMID:25120851)
• MicroRNA-107 is upregulated in gastric cancer (GC)and affects the proliferation of GC cells, partially through the regulation of CDK8. (PMID:25163571)
• Results show that overexpression of miR-107 and miR-99a-3p were significantly associated with improved progression-free and/or overall survival. (PMID:25197016)
• The effect of miR107 on K562 and KCL22 cells was mediated through the downregulation of Cacna2d1, as rescued expression of Cacna2d1 reversed the effects of miR107. (PMID:25373460)
• miR-107 directly targeted MCL1 and activated ATR/Chk1 pathway to inhibit proliferation, migration and invasiveness of cervical cancer cells. (PMID:25386925)
• CHGA 3’-UTR C+87T disrupts an miR-107 motif (PMID:25392232)
• Suggest that miR-107 plays a key role in cisplatin resistance by targeting the CDK8 protein in non small cell lung cancer cells. (PMID:25400821)
• it is the first data to prove that expression level of miR-107 may be a novel and valuable prognostic factor in glioma. (PMID:25596705)
• microRNA family (miRs-103/107) preferentially expressed in the stem cell-enriched limbal epithelium regulates and integrates these stem cell characteristics. (PMID:25639731)
• miR-107 is dysregulated in gastric adenocarcinoma pathogenesis and the SNP rs2296616 may play a role in the process. (PMID:25771723)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-103	ENSDARG00000081583
danio_rerio	mir107b	ENSDARG00000081704
danio_rerio	dre-mir-107	ENSDARG00000083423

Paralogs (2): MIR103A2 (ENSG00000199024), MIR103A1 (ENSG00000199035)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.