MIR10A

Summary

MIR10A (microRNA 10a, HGNC:31497) is a microRNA gene on chromosome 17q21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406902 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31497
Approved symbol	MIR10A
Name	microRNA 10a
Location	17q21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-10a
Ensembl gene	ENSG00000284038
Ensembl biotype	miRNA
OMIM	610173
Entrez	406902
RNAcentral	URS000048795E — miRNA, 110 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385043

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385043 — 1 exons

Exon	Start	End
ENSE00001500050	48579838	48579947

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 69.56.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle layer of sigmoid colon	UBERON:0035805	69.56	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.72	gold quality
body of stomach	UBERON:0001161	68.10	gold quality
epididymis	UBERON:0001301	67.22	gold quality
ascending aorta	UBERON:0001496	66.99	gold quality
lung	UBERON:0002048	66.70	gold quality
skin of leg	UBERON:0001511	65.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.69	gold quality
stomach	UBERON:0000945	65.45	gold quality
skin of abdomen	UBERON:0001416	65.38	gold quality
spleen	UBERON:0002106	63.96	gold quality
renal glomerulus	UBERON:0000074	63.92	gold quality
omental fat pad	UBERON:0010414	63.78	gold quality
placenta	UBERON:0001987	63.77	gold quality
upper lobe of left lung	UBERON:0008952	63.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.55	gold quality
endometrium	UBERON:0001295	62.26	gold quality
uterus	UBERON:0000995	62.25	gold quality
tibial nerve	UBERON:0001323	61.27	gold quality
mucosa of stomach	UBERON:0001199	60.90	gold quality
esophagus	UBERON:0001043	60.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.33	gold quality
thoracic mammary gland	UBERON:0005200	60.17	gold quality
transverse colon	UBERON:0001157	60.16	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.62	gold quality
esophagus mucosa	UBERON:0002469	57.81	gold quality
prostate gland	UBERON:0002367	54.93	gold quality
left testis	UBERON:0004533	54.13	gold quality
testis	UBERON:0000473	54.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NFKB

Literature-anchored findings (GeneRIF, showing 40)

• miRNA 17-5p, 20a and 126 are constitutively expressed in Ph(-) MPN megakaryopoiesis while low or absent miRNA 10a appeared to correlate with strong megakaryocytic HOXA1 protein expression (PMID:18773208)
• down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of chronic myeloid leukemia implicating a miRNA in its abnormal behavior (PMID:19074828)
• miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts; in addition, members of the miR-10 family are de-regulated in several cancer forms (PMID:19461655)
• MiR-10a is associated with the process of HOXA 1-mediated transformation. (PMID:19462682)
• Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. (PMID:19747919)
• expressed altered in esophageal squamous cell carcinoma (PMID:20588024)
• changes in miR-10a and -10b expression levels may regulate SFRS1-dependent alternative splicing and translational functions. (PMID:21118818)
• The miR-10a has major roles in the process of neural cell differentiation through direct targeting of NCOR2, which in turn induces a cascade of primary and secondary transcriptional alterations. (PMID:21212796)
• miR-10a is specifically upregulated in nucleophosmin 1 (NPM1) mutant AML bone marrow. A robust negative relationship exists between miR-10a overexpression & MDM4 downregulation. (PMID:21784052)
• This study provides, for the first time, in vitro evidence of a pro-survival role of miR-10a in NPM1mut-AML, that it may contribute to the pathogenesis of NPM1 mutated (NPM1mut)-AML and identifies putative tumorogenic targets. (PMID:22348345)
• MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness. (PMID:22407312)
• miR-10a expression is upregulated in cervical cancer tissues, and miR-10a promotes cell growth, migration and invasion by targeting CHL1 in human cervical cancer cells. (PMID:22634495)
• Data show that the increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in umbilical venous endothelial cells inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling. (PMID:22955733)
• miR-10a expression is downregulated in hepatocellular carcinoma compared to non-tumor tissue. (PMID:22976466)
• TWIST-1 and miR10a/b expression are dysregulated in MDS. Expression of miRs10a/b is controlled by TWIST-1. (PMID:22983574)
• miR-10a can promote hepatocellular carcinoma (HCC) migration and invasion in vitro but suppresses the metastasis of HCC in vivo (PMID:22996586)
• microRNA-10a and microRNA-30d have roles in kidney injury (PMID:23272089)
• Data indicate that MiR-10a has a role in megakaryocyte differentiation of stem cells via HOXA1 transcription factor targeting. (PMID:23321646)
• MiR-375 and miR-10a were overexpressed in medullary thyroid carcinoma. (PMID:23685355)
• MiR-10a restores the differentiation capability of aged hMSCs through repression of KLF4. (PMID:23696417)
• In conclusion, our studies in multiple bladder cancer cell lines and primary non-malignant urothelial cells suggest that hypermethylation of miR-152, miR-10a and miR-200b regulative DNA sequences might serve as epigenetic bladder cancer biomarkers. (PMID:23867826)
• miR-126 and miR-10a are independent predictors for tumour relapse in early postmenopausal breast cancer patients treated with adjuvant tamoxifen. (PMID:23968733)
• TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN. (PMID:24100613)
• miR-10a was up-regulated during endodermal differentiation of PMSCs and involved in its differentiation partially via the suppression of the Hoxa1 gene (PMID:24103260)
• This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. (PMID:24412053)
• MicroRNA-10a has a role in controlling airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway (PMID:24522205)
• miR-10a inhibits TBX5 expression at the level of translation. Higher levels of miR-10a expression are associated with a higher risk of congenital heart defects. (PMID:24714979)
• miR-10a is overexpressed in cervical tumor tissues with lymph node metastasis, and miR-10a may significantly enhance the migration and invasion capacities of cervical cancer cells by inhibiting PTEN at the transcriptional level. (PMID:25018014)
• Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b (PMID:25266482)
• In heavy alcohol drinkers, MIR10A expression was upregulated in blood following psychological stress but not in moderate drinkers. (PMID:25421511)
• we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression (PMID:25554417)
• Human fetal hypoplastic congenital diaphragmatic hernia (CDH) lungs have a specific miR-200/miR-10a signature. (PMID:25563880)
• MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway (PMID:25586740)
• Therefore, the expression of ADAR1 and ADAR2 was analyzed in chordoma tissues. It was found that ADAR1 was significantly overexpressed, which was accompanied by enhanced pre-miR-10a and pri-miR-125a A-to-I editing (PMID:25673044)
• Human miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect glioma cell migration and invasion. (PMID:25683004)
• MIR10A plays a potential tumour suppressor role in human breast cancer. (PMID:25934412)
• MiRNA-10a is upregulated in non-small cell lung carcinoma and activates PTEN/AKT/ERK pathway. (PMID:26317552)
• miR-10 is specifically expressed in the developing human hindbrain and spinal cord, and regulates a large number of genes enriched for functions including transcription, actin cytoskeleton and ephrin receptor signaling. (PMID:26395143)
• MicroRNA assays are shown to have great potential to be accurate and noninvasive methods for ESCC screening. In this study, we selected 3 microRNAs, miR-10b, miR-29c, and miR-205, to assess their diagnostic value in ESCC screening. (PMID:26554762)
• MiRNA-10a down regulation is an important element in untreated juvenile dermatomyositis muscle pathology. (PMID:26628598)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir10c	ENSDARG00000081638
danio_rerio	mir10a	ENSDARG00000082315
mus_musculus	Mir10a	ENSMUSG00000065519
rattus_norvegicus	Mir10a	ENSRNOG00000035535
drosophila_melanogaster	mir-10	FBGN0262424

Paralogs (7): MIR99B (ENSG00000207550), MIR99A (ENSG00000207638), MIR10B (ENSG00000207744), MIR125B2 (ENSG00000207863), MIR125B1 (ENSG00000207971), MIR100 (ENSG00000207994), MIR125A (ENSG00000208008)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.