MIR1178

Summary

MIR1178 (microRNA 1178, HGNC:35259) is a microRNA gene on chromosome 12q24.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302274 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35259
Approved symbol	MIR1178
Name	microRNA 1178
Location	12q24.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1178
Ensembl gene	ENSG00000283768
Ensembl biotype	miRNA
Entrez	100302274
RNAcentral	URS000075AF6E — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408396

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408396 — 1 exons

Exon	Start	End
ENSE00001565031	119713634	119713724

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 74.52.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
putamen	UBERON:0001874	74.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.82	gold quality
nucleus accumbens	UBERON:0001882	67.69	gold quality
omental fat pad	UBERON:0010414	66.80	gold quality
gastrocnemius	UBERON:0001388	66.54	gold quality
left coronary artery	UBERON:0001626	64.05	gold quality
hypothalamus	UBERON:0001898	63.70	gold quality
vagina	UBERON:0000996	62.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.76	gold quality
skin of abdomen	UBERON:0001416	60.10	gold quality
thyroid gland	UBERON:0002046	59.27	gold quality
skin of leg	UBERON:0001511	58.41	gold quality
spleen	UBERON:0002106	58.10	gold quality
right lobe of thyroid gland	UBERON:0001119	56.92	gold quality
pituitary gland	UBERON:0000007	55.33	gold quality
body of stomach	UBERON:0001161	52.77	gold quality
tibial nerve	UBERON:0001323	52.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	42.21	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• miR-1178 acts as an oncomiR in pancreatic cancer cells by inhibiting CHIP expression. (PMID:25635996)
• Overexpression of miR-1178 promoted mycobacteria survival and miR-1178 also modulated the immune response of Mycobacterium tuberculosis-infected macrophages partly via targeting TLR4. (PMID:29781535)
• miR-1178-3p acts as an onco-miRNA in nasopharyngeal carcinoma by suppressing STK4 expression (PMID:30972994)
• Gene-level analysis further revealed a significant genome-wide association of a microRNA-encoding gene MIR1178 in both the discovery and replication cohorts. Another gene poly(A)-binding protein nuclear 1 like, cytoplasmic (PABPN1L) showed suggestive significance in the discovery cohort (p < 1 x 10(-4)) and was replicated in the replication cohort (p = 0.009). (PMID:31363184)
• These results reveal that Circ-ZKSCAN1 acts as a tumor suppressor via a novel circ-ZKSCAN1/miR-1178-3p/p21 axis, which have the important role in the proliferation, migration and invasion ablitities of BCa cells and provide a novel perspective on circRNAs in BCa progression. (PMID:31481066)
• Mapping genetic variability in mature miRNAs and miRNA binding sites in prostate cancer. (PMID:34099864)
• MicroRNA-1178-3p suppresses the growth of hepatocellular carcinoma by regulating transducin (beta)-like 1 X-linked receptor 1. (PMID:34125401)
• Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer. (PMID:35902926)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.