MIR1179

Summary

MIR1179 (microRNA 1179, HGNC:35260) is a microRNA gene on chromosome 15q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302235 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35260
Approved symbol	MIR1179
Name	microRNA 1179
Location	15q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1179
Ensembl gene	ENSG00000221630
Ensembl biotype	miRNA
OMIM	620899
Entrez	100302235
RNAcentral	URS000075A3C1 — miRNA, 91 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408703

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408703 — 1 exons

Exon	Start	End
ENSE00001565338	88608107	88608197

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 84.99.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.99	gold quality
pituitary gland	UBERON:0000007	79.63	gold quality
adenohypophysis	UBERON:0002196	76.10	gold quality
adrenal gland	UBERON:0002369	75.87	gold quality
islet of Langerhans	UBERON:0000006	75.85	gold quality
Ammon’s horn	UBERON:0001954	74.21	gold quality
heart left ventricle	UBERON:0002084	73.92	gold quality
left adrenal gland cortex	UBERON:0035825	73.71	gold quality
stomach	UBERON:0000945	73.50	gold quality
right lobe of thyroid gland	UBERON:0001119	72.49	gold quality
blood	UBERON:0000178	72.33	gold quality
endometrium	UBERON:0001295	71.48	gold quality
gastrocnemius	UBERON:0001388	71.47	gold quality
left adrenal gland	UBERON:0001234	71.41	gold quality
monocyte	CL:0000576	71.17	gold quality
omental fat pad	UBERON:0010414	70.27	gold quality
hypothalamus	UBERON:0001898	69.44	gold quality
tibial artery	UBERON:0007610	68.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.22	gold quality
tonsil	UBERON:0002372	68.06	gold quality
ascending aorta	UBERON:0001496	67.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.84	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.63	gold quality
thoracic aorta	UBERON:0001515	67.40	gold quality
esophagus mucosa	UBERON:0002469	67.23	gold quality
intestine	UBERON:0000160	66.67	gold quality
right frontal lobe	UBERON:0002810	66.66	gold quality
putamen	UBERON:0001874	66.65	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.65	gold quality
body of stomach	UBERON:0001161	66.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• The expression of miR-1179 was significantly associated with familial breast cancer patients without BRCA1 mutations. (PMID:25273865)
• We found that miR-1179 was up-regulated in human esophageal squamous cell carcinoma tumor tissues (PMID:25755718)
• miR-1179 overexpression could also inhibit tumor growth in vivo by suppressing the expression of E2F5. (PMID:29859832)
• miR-1179 inhibits the growth and invasion of non-small cell lung cancer cells by targeting SPAG5 and inhibiting Akt (PMID:30180955)
• miR-1179 up-regulation inhibited the expression of Notch 1, Notch 4 and Hes1, indicating that miR-1179 could suppress the activation of the Notch signaling pathway and inhibit tumor cell proliferation, migration and invasion. (PMID:30556878)
• Circ_0000735 exerts oncogenic properties in non-small cell lung cancer cells which is partly dependent on its regulation on miR-1179 and miR-1182. (PMID:30737027)
• MiR-1179 is sponged by circular RNA circ_0003645 and TMEM14A is a target of miR-1179. (PMID:30853176)
• miR-1179/HMGB1 axis plays a role in the progression of gastric cancer. (PMID:30903594)
• The microRNApolymorphisms inmiR-150 and miR-1179 are associated with risk of idiopathic recurrent pregnancy loss. (PMID:31182356)
• Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways. (PMID:31270819)
• MiRNA-1179 suppresses the metastasis of hepatocellular carcinoma by interacting with ZEB2. (PMID:31298368)
• LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis. (PMID:32131767)
• Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis. (PMID:33926347)
• CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis. (PMID:34903799)
• CircRNA circ_0043533 facilitates cell growth in polycystic ovary syndrome by targeting miR-1179. (PMID:35338913)
• Long Non-Coding RNA LINC01929 Facilitates Cell Proliferation and Metastasis as a Competing Endogenous RNA Against MicroRNA miR-1179 in Non-Small Cell Lung Carcinoma. (PMID:35996496)
• MicroRNA-1179 targets Epiregulin (EREG) regulates the proliferation and metastasis of human multiple myeloma cells. (PMID:37329522)
• Hsa_circ_0007292 promotes chondrocyte injury in osteoarthritis via targeting the miR-1179/HMGB1 axis. (PMID:37516834)
• STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179. (PMID:38714869)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.