MIR1180

Summary

MIR1180 (microRNA 1180, HGNC:35261) is a microRNA gene on chromosome 17p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302256 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35261
Approved symbol	MIR1180
Name	microRNA 1180
Location	17p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1180
Ensembl gene	ENSG00000221540
Ensembl biotype	miRNA
Entrez	100302256
RNAcentral	URS0000657D34 — miRNA, 69 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408613

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408613 — 1 exons

Exon	Start	End
ENSE00001565248	19344506	19344574

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 92.48.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.48	gold quality
calcaneal tendon	UBERON:0003701	80.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.95	gold quality
right uterine tube	UBERON:0001302	78.43	gold quality
pituitary gland	UBERON:0000007	78.05	gold quality
prefrontal cortex	UBERON:0000451	76.51	gold quality
body of pancreas	UBERON:0001150	75.98	gold quality
right adrenal gland cortex	UBERON:0035827	75.65	gold quality
left uterine tube	UBERON:0001303	75.44	gold quality
muscle of leg	UBERON:0001383	75.25	gold quality
left lobe of thyroid gland	UBERON:0001120	75.17	gold quality
left adrenal gland cortex	UBERON:0035825	75.03	gold quality
metanephros cortex	UBERON:0010533	75.02	gold quality
body of uterus	UBERON:0009853	75.00	gold quality
left adrenal gland	UBERON:0001234	74.89	gold quality
right ovary	UBERON:0002118	74.87	gold quality
right coronary artery	UBERON:0001625	74.57	gold quality
right adrenal gland	UBERON:0001233	74.45	gold quality
adenohypophysis	UBERON:0002196	74.32	gold quality
endocervix	UBERON:0000458	74.11	gold quality
thyroid gland	UBERON:0002046	74.03	gold quality
mucosa of stomach	UBERON:0001199	73.79	gold quality
left ovary	UBERON:0002119	73.71	gold quality
gastrocnemius	UBERON:0001388	73.16	gold quality
fallopian tube	UBERON:0003889	73.01	gold quality
blood	UBERON:0000178	72.81	gold quality
myometrium	UBERON:0001296	72.72	gold quality
right lobe of thyroid gland	UBERON:0001119	72.60	gold quality
heart left ventricle	UBERON:0002084	72.36	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• this study shows that ectopic expression of miR-1180 has an anti-apoptotic effect in hepatocellular carcinoma through NF-kappaB pathway activation (PMID:26928365)
• miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. (PMID:27044843)
• our study provides evidence that up-regulation of p21 is mainly responsible for the suppressive effect of miR-1180-5p on human bladder cancer cells and miR-1180-5p can significantly inhibit tumorigenicity in vivo. (PMID:27112784)
• bone marrow-derived mesenchymal stem cells enhance the chemoresistance of ovarian cancer by releasing miR-1180 (PMID:30829010)
• DNA methylation-mediated F11-AS1 and F11-AS1/miR-1180-3p/C11of54 ceRNA regulatory axis has played an important role in the occurrence and development of hepatocellular carcinoma (PMID:32660176)
• Clinical significance of miR-1180-3p in hepatocellular carcinoma: a study based on bioinformatics analysis and RT-qPCR validation. (PMID:32665670)
• Clinical significance of microRNA-1180-3p for colorectal cancer and effect of its alteration on cell function. (PMID:34723759)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.