MIR1181

Summary

MIR1181 (microRNA 1181, HGNC:35262) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302213 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35262
Approved symbol	MIR1181
Name	microRNA 1181
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1181
Ensembl gene	ENSG00000284268
Ensembl biotype	miRNA
Entrez	100302213
RNAcentral	URS000075EF45 — miRNA, 81 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408639

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408639 — 1 exons

Exon	Start	End
ENSE00001565274	10403458	10403538

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 95.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 132.7402 / max 973.6987, expressed in 1828 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179128	132.7402	1828

Top tissues by expression

2 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	95.95	gold quality
sural nerve	UBERON:0015488	95.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Low miR-1181 expression was associated with pancreatic cancer. (PMID:25444909)
• ARK5 was upregulated in ovarian cancer tissues, promoted epithelialmesenchymal transition and inhibited miR-1181 expression in ovarian cancer cells (PMID:26151663)
• miR-1181 may be involved in pancreatic cancer cell invasion and proliferation by targeting STAT3 (PMID:28321160)
• Data suggest that serum levels of MIRN1181 and MIRN4314 are significantly up-regulated in women with ovarian cancer stages I-IV as compared to normal subjects. [PILOT PROJECT] (PMID:29353130)
• The miR-1181/STAT3 axis mediated PDGFBB-induced dysfunction in human PASMCs. (PMID:30211651)
• We found that miR-1181 expression was significantly down-regulated in both nasopharyngeal carcinoma tissues and cell lines and independently associated with the overall survival. (PMID:30779075)
• AXIN1 showed a negative correlation with that of miR-1181 in hepatocellular carcinoma. (PMID:31514071)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.