MIR1182

Summary

MIR1182 (microRNA 1182, HGNC:35263) is a microRNA gene on chromosome 1q42.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302132 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35263
Approved symbol	MIR1182
Name	microRNA 1182
Location	1q42.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1182
Ensembl gene	ENSG00000283799
Ensembl biotype	miRNA
Entrez	100302132
RNAcentral	URS000075C9F5 — miRNA, 97 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408363

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408363 — 1 exons

Exon	Start	End
ENSE00001564998	231019828	231019924

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 84.66.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	84.66	gold quality
stomach	UBERON:0000945	75.88	gold quality
duodenum	UBERON:0002114	75.22	gold quality
blood	UBERON:0000178	72.79	gold quality
endometrium	UBERON:0001295	72.54	gold quality
body of pancreas	UBERON:0001150	70.95	gold quality
adrenal tissue	UBERON:0018303	70.95	gold quality
lung	UBERON:0002048	69.52	gold quality
islet of Langerhans	UBERON:0000006	69.21	gold quality
body of stomach	UBERON:0001161	69.21	gold quality
small intestine	UBERON:0002108	68.03	gold quality
upper lobe of left lung	UBERON:0008952	67.45	gold quality
muscle of leg	UBERON:0001383	66.87	gold quality
gastrocnemius	UBERON:0001388	65.63	gold quality
tibial artery	UBERON:0007610	63.68	gold quality
transverse colon	UBERON:0001157	63.41	gold quality
heart left ventricle	UBERON:0002084	63.30	gold quality
colon	UBERON:0001155	63.09	gold quality
heart	UBERON:0000948	62.99	gold quality
esophagus mucosa	UBERON:0002469	62.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.43	gold quality
adult mammalian kidney	UBERON:0000082	62.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.92	gold quality
body of uterus	UBERON:0009853	60.83	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.82	gold quality
minor salivary gland	UBERON:0001830	60.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.89	gold quality
prostate gland	UBERON:0002367	58.81	gold quality
right atrium auricular region	UBERON:0006631	55.45	gold quality
ascending aorta	UBERON:0001496	55.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Authors found a statistically significant inverse correlation between miR-1182 and hTERT protein levels in tissues from 42 gastric cancer patients. These data indicate that miR-1182 suppresses TERT. (PMID:25662441)
• In conclusion, these results demonstrate that miR-1182 acts as a tumor suppressor and may be a potential biomarker for bladder cancer diagnosis and treatment. (PMID:26772886)
• Circ_0000735 exerts oncogenic properties in non-small cell lung cancer cells which is partly dependent on its regulation on miR-1179 and miR-1182. (PMID:30737027)
• Circular RNA circABCC4 as the ceRNA of miR-1182 facilitates prostate cancer progression by promoting FOXP4 expression. (PMID:31270953)
• Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway. (PMID:32768951)
• The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1. (PMID:33289016)
• Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis. (PMID:33976535)
• Circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway. (PMID:34837947)
• CircCAMSAP1 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis by sponging miR-1182 and regulating BIRC5. (PMID:35132928)
• Circ_0002476 regulates cell growth, invasion, and mtDNA damage in non-small cell lung cancer by targeting miR-1182/TFAM axis. (PMID:36056804)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.