MIR1183

Summary

MIR1183 (microRNA 1183, HGNC:35264) is a microRNA gene on chromosome 7p15.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302122 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35264
Approved symbol	MIR1183
Name	microRNA 1183
Location	7p15.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1183
Ensembl gene	ENSG00000221783
Ensembl biotype	miRNA
Entrez	100302122
RNAcentral	URS00006E1030 — miRNA, 89 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408856

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408856 — 1 exons

Exon	Start	End
ENSE00001565491	21471058	21471146

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 96.19.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.19	gold quality
bone marrow	UBERON:0002371	85.33	gold quality
blood	UBERON:0000178	80.58	gold quality
calcaneal tendon	UBERON:0003701	79.83	gold quality
kidney	UBERON:0002113	74.13	gold quality
gastrocnemius	UBERON:0001388	73.92	gold quality
adrenal tissue	UBERON:0018303	73.50	gold quality
stomach	UBERON:0000945	73.44	gold quality
monocyte	CL:0000576	73.15	gold quality
endometrium	UBERON:0001295	73.00	gold quality
heart	UBERON:0000948	71.76	gold quality
heart left ventricle	UBERON:0002084	71.63	gold quality
tibial artery	UBERON:0007610	70.42	gold quality
thoracic mammary gland	UBERON:0005200	70.34	gold quality
right atrium auricular region	UBERON:0006631	70.03	gold quality
ascending aorta	UBERON:0001496	69.20	gold quality
thoracic aorta	UBERON:0001515	68.95	gold quality
body of pancreas	UBERON:0001150	68.67	gold quality
body of stomach	UBERON:0001161	68.45	gold quality
intestine	UBERON:0000160	68.20	gold quality
lung	UBERON:0002048	68.03	gold quality
liver	UBERON:0002107	67.88	gold quality
colon	UBERON:0001155	67.83	gold quality
anterior cingulate cortex	UBERON:0009835	67.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.39	gold quality
putamen	UBERON:0001874	66.80	gold quality
esophagus mucosa	UBERON:0002469	66.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.32	gold quality
transverse colon	UBERON:0001157	66.29	gold quality
skin of abdomen	UBERON:0001416	65.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• miR-1183 and miR-1299 appear to play distinct roles in rheumatic heart disease pathogenesis accompanied by secondary PAH and could be used as potential biological markers for disease development. (PMID:26539505)
• the oncogenic effects of hsa_circ_0004015 was attributed to the regulation of miR-1183/PDPK1 axis. (PMID:30509491)
• miR-198 and miR-1183 were the two most significantly up-regulated microRNAs, and, miR-30e-5p and miR-144-3p were the two most significantly down-regulated microRNAs in Uyghur population with essential hypertension. (PMID:30975221)
• circ_0005273 promotes thyroid carcinoma progression by SOX2 expression. (PMID:31693489)
• CircCDK14 ameliorates interleukin-1beta-induced chondrocyte damage by the miR-1183/KLF5 pathway in osteoarthritis. (PMID:35723551)
• miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium. (PMID:35805966)
• Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer. (PMID:36241055)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.