MIR1184-1

Summary

MIR1184-1 (microRNA 1184-1, HGNC:35265) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302111 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35265
Approved symbol	MIR1184-1
Name	microRNA 1184-1
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1184
Ensembl gene	ENSG00000221533
Ensembl biotype	miRNA
Entrez	100302111
RNAcentral	URS000075A55D — miRNA, 99 nt, 18 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408606

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408606 — 1 exons

Exon	Start	End
ENSE00001807744	154887360	154887458

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 84.74.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	84.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	81.19	gold quality
hypothalamus	UBERON:0001898	79.05	gold quality
cerebral cortex	UBERON:0000956	77.92	gold quality
blood	UBERON:0000178	75.68	gold quality
heart left ventricle	UBERON:0002084	71.75	gold quality
gastrocnemius	UBERON:0001388	71.53	gold quality
muscle of leg	UBERON:0001383	70.97	gold quality
vermiform appendix	UBERON:0001154	68.72	gold quality
left lobe of thyroid gland	UBERON:0001120	68.07	gold quality
small intestine	UBERON:0002108	66.80	gold quality
putamen	UBERON:0001874	64.80	gold quality
upper lobe of left lung	UBERON:0008952	64.08	gold quality
body of stomach	UBERON:0001161	64.01	gold quality
right lobe of thyroid gland	UBERON:0001119	63.29	gold quality
islet of Langerhans	UBERON:0000006	62.88	gold quality
lung	UBERON:0002048	62.47	gold quality
skin of leg	UBERON:0001511	61.81	gold quality
left ovary	UBERON:0002119	60.50	gold quality
tibial nerve	UBERON:0001323	59.61	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.25	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.72	gold quality
vagina	UBERON:0000996	58.36	gold quality
endometrium	UBERON:0001295	57.05	gold quality
right atrium auricular region	UBERON:0006631	57.04	gold quality
tibial artery	UBERON:0007610	55.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.64	gold quality
body of pancreas	UBERON:0001150	52.14	gold quality
saliva-secreting gland	UBERON:0001044	50.49	silver quality
esophagus mucosa	UBERON:0002469	47.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• In prostatic cancer, there is a significant increase in plasma hsa-miR-619-5p and hsa-miR-1184 microRNA expression. (PMID:27265125)
• miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1. (PMID:32619668)
• Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling. (PMID:32681581)
• ExosomalmiR1184 derived from mesenchymal stem cells alleviates cisplatinassociated acute kidney injury. (PMID:34515319)
• Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells. (PMID:34559381)
• Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis. (PMID:34626691)
• Estrogen receptor beta2 (ERbeta2)-mediated upregulation of hsa_circ_0000732 promotes tumor progression via sponging microRNA-1184 in triple-negative breast cancer (TNBC). (PMID:35064304)
• Hsa_circ_0010729 regulates H2O2-induced myocardial injury by regulating miR-1184/RIPK1 axis. (PMID:35772682)
• CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis. (PMID:36810972)
• Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis. (PMID:36958293)
• Hsa_circ_0000073 promotes lipid synthesis of osteosarcoma through hsa-miR-1184/ FADS2 pathway. (PMID:37506860)

Cross-species orthologs

0 orthologs

Paralogs (2): MIR1184-2 (ENSG00000221190), MIR1184-3 (ENSG00000221603)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.