MIR1185-1

Summary

MIR1185-1 (microRNA 1185-1, HGNC:35257) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302157 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35257
Approved symbol	MIR1185-1
Name	microRNA 1185-1
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1185-1
Ensembl gene	ENSG00000221525
Ensembl biotype	miRNA
Entrez	100302157
RNAcentral	URS000075CEFC — miRNA, 86 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408598

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408598 — 1 exons

Exon	Start	End
ENSE00001807614	101042977	101043062

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 94.75.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	94.75	gold quality
colon	UBERON:0001155	93.89	gold quality
cerebellar vermis	UBERON:0004720	93.80	gold quality
quadriceps femoris	UBERON:0001377	92.34	gold quality
kidney	UBERON:0002113	87.78	gold quality
calcaneal tendon	UBERON:0003701	85.89	gold quality
lung	UBERON:0002048	85.24	gold quality
intestine	UBERON:0000160	83.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.60	gold quality
skeletal muscle tissue	UBERON:0001134	82.30	silver quality
thymus	UBERON:0002370	81.08	silver quality
stomach	UBERON:0000945	80.92	gold quality
spinal cord	UBERON:0002240	79.66	silver quality
testis	UBERON:0000473	76.96	gold quality
right atrium auricular region	UBERON:0006631	75.58	gold quality
bone marrow	UBERON:0002371	75.08	silver quality
placenta	UBERON:0001987	74.90	gold quality
heart	UBERON:0000948	74.72	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.65	gold quality
blood	UBERON:0000178	73.80	gold quality
corpus callosum	UBERON:0002336	73.72	gold quality
gastrocnemius	UBERON:0001388	73.49	gold quality
liver	UBERON:0002107	72.06	silver quality
pancreas	UBERON:0001264	71.18	gold quality
body of pancreas	UBERON:0001150	70.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.78	gold quality
endometrium	UBERON:0001295	68.22	gold quality
left ovary	UBERON:0002119	67.71	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.75	gold quality
ascending aorta	UBERON:0001496	66.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• The miR-1185 has pro-apoptosis effects on endothelial cells by directly targeting ultraviolet irradiation resistance-associated gene (UVRAG) and krev1 interaction trapped gene 1(KTIT1). (PMID:28441650)
• The miR-1185 modulated the expression of vascular cell adhesion molecule-1 and E-selectin to promote arterial stiffening, suggesting that miR-1185 plays a crucial role in the development of atherosclerosis. (PMID:28441665)
• miR-548q and miR-1185-1 levels in WBCs are biomarkers of response to weight-loss diets and could be involved in the regulation of the proinflammatory gene GSK3B. (PMID:31801236)
• SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness. (PMID:33046442)
• MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism. (PMID:38674063)

Cross-species orthologs

0 orthologs

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-2 (ENSG00000221614), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.