MIR1185-2

Summary

MIR1185-2 (microRNA 1185-2, HGNC:35254) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302209 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35254
Approved symbol	MIR1185-2
Name	microRNA 1185-2
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1185-2
Ensembl gene	ENSG00000221614
Ensembl biotype	miRNA
Entrez	100302209
RNAcentral	URS000075B319 — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408687

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408687 — 1 exons

Exon	Start	End
ENSE00001806916	101044198	101044283

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 96.43.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.43	gold quality
stomach	UBERON:0000945	84.02	gold quality
monocyte	CL:0000576	82.01	gold quality
kidney	UBERON:0002113	81.16	gold quality
adult mammalian kidney	UBERON:0000082	81.04	gold quality
calcaneal tendon	UBERON:0003701	80.89	gold quality
prefrontal cortex	UBERON:0000451	74.93	gold quality
myometrium	UBERON:0001296	74.70	gold quality
placenta	UBERON:0001987	73.94	gold quality
lung	UBERON:0002048	73.62	gold quality
intestine	UBERON:0000160	72.92	gold quality
liver	UBERON:0002107	72.31	gold quality
body of pancreas	UBERON:0001150	72.13	gold quality
gastrocnemius	UBERON:0001388	71.37	gold quality
heart left ventricle	UBERON:0002084	71.22	gold quality
endometrium	UBERON:0001295	69.90	gold quality
left ovary	UBERON:0002119	68.91	gold quality
ovary	UBERON:0000992	68.85	gold quality
colon	UBERON:0001155	68.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.18	gold quality
right adrenal gland cortex	UBERON:0035827	67.83	gold quality
upper lobe of left lung	UBERON:0008952	67.66	gold quality
ascending aorta	UBERON:0001496	66.93	gold quality
Ammon’s horn	UBERON:0001954	66.66	gold quality
right adrenal gland	UBERON:0001233	66.55	gold quality
nucleus accumbens	UBERON:0001882	66.55	gold quality
transverse colon	UBERON:0001157	66.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.31	gold quality
left adrenal gland cortex	UBERON:0035825	66.20	gold quality
substantia nigra	UBERON:0002038	65.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The miR-1185 has pro-apoptosis effects on endothelial cells by directly targeting ultraviolet irradiation resistance-associated gene (UVRAG) and krev1 interaction trapped gene 1(KTIT1). (PMID:28441650)
• The miR-1185 modulated the expression of vascular cell adhesion molecule-1 and E-selectin to promote arterial stiffening, suggesting that miR-1185 plays a crucial role in the development of atherosclerosis. (PMID:28441665)
• Increased levels of Increased levels of miR-1185-2-3p in serum are associated with prostate cancer. (PMID:30808771)
• The miR-1185-2-3p-GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1. (PMID:33509226)

Cross-species orthologs

0 orthologs

Paralogs (16): MIR494 (ENSG00000194717), MIR377 (ENSG00000199015), MIR381 (ENSG00000199020), MIR369 (ENSG00000199025), MIR323A (ENSG00000199069), MIR410 (ENSG00000199092), MIR409 (ENSG00000199107), MIR539 (ENSG00000202560), MIR487A (ENSG00000207742), MIR487B (ENSG00000207754), MIR656 (ENSG00000207959), MIR496 (ENSG00000207961), MIR154 (ENSG00000207978), MIR323B (ENSG00000208004), MIR1185-1 (ENSG00000221525), MIR382 (ENSG00000283170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.