MIR1193

Summary

MIR1193 (microRNA 1193, HGNC:38247) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422837 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38247
Approved symbol	MIR1193
Name	microRNA 1193
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1193
Ensembl gene	ENSG00000221036
Ensembl biotype	miRNA
Entrez	100422837
RNAcentral	URS000075C2A9 — miRNA, 78 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408109

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408109 — 1 exons

Exon	Start	End
ENSE00001564744	101030052	101030129

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 97.06.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	97.06	gold quality
stomach	UBERON:0000945	85.52	gold quality
liver	UBERON:0002107	82.56	gold quality
kidney	UBERON:0002113	82.22	gold quality
lung	UBERON:0002048	78.06	gold quality
placenta	UBERON:0001987	77.84	gold quality
heart	UBERON:0000948	77.37	gold quality
muscle of leg	UBERON:0001383	77.07	gold quality
intestine	UBERON:0000160	75.73	gold quality
blood	UBERON:0000178	75.11	gold quality
calcaneal tendon	UBERON:0003701	74.62	gold quality
gastrocnemius	UBERON:0001388	74.61	gold quality
colon	UBERON:0001155	72.40	gold quality
islet of Langerhans	UBERON:0000006	72.08	gold quality
putamen	UBERON:0001874	68.81	gold quality
substantia nigra	UBERON:0002038	68.80	gold quality
Ammon’s horn	UBERON:0001954	68.35	gold quality
corpus callosum	UBERON:0002336	68.17	gold quality
heart left ventricle	UBERON:0002084	66.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.83	gold quality
body of pancreas	UBERON:0001150	66.06	gold quality
tibial artery	UBERON:0007610	66.03	gold quality
left ovary	UBERON:0002119	66.00	gold quality
endometrium	UBERON:0001295	64.49	gold quality
left adrenal gland	UBERON:0001234	63.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.74	gold quality
omental fat pad	UBERON:0010414	63.65	gold quality
tibial nerve	UBERON:0001323	63.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.40	gold quality
right ovary	UBERON:0002118	62.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Authors confirmed that TM9SF3 was a target gene of miR-1193 by luciferase reporter gene assay. Gene overexpression and knockdown experiments in Jurkat cells revealed that TM9SF3 positively regulated cell proliferation and invasion. (PMID:28390114)
• hsa-miR-1193 may be involved in sporadic colorectal cancer tumourigenesis at least in part by suppression of TGFBR2, and the A allele of rs11466537 disturbed the regulation of hsa-miR-1193 on TGFBR2. (PMID:28494187)
• Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs. (PMID:32732911)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.