MIR1197

Summary

MIR1197 (microRNA 1197, HGNC:35376) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302250 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35376
Approved symbol	MIR1197
Name	microRNA 1197
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1197
Ensembl gene	ENSG00000221745
Ensembl biotype	miRNA
Entrez	100302250
RNAcentral	URS000075B597 — miRNA, 88 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408818

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408818 — 1 exons

Exon	Start	End
ENSE00001565453	101025564	101025651

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 90.40.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	90.40	gold quality
kidney	UBERON:0002113	87.94	gold quality
stomach	UBERON:0000945	83.86	gold quality
intestine	UBERON:0000160	81.19	gold quality
lung	UBERON:0002048	80.41	gold quality
blood	UBERON:0000178	80.05	gold quality
colon	UBERON:0001155	78.84	gold quality
body of pancreas	UBERON:0001150	76.88	gold quality
heart	UBERON:0000948	74.30	gold quality
corpus callosum	UBERON:0002336	73.06	gold quality
monocyte	CL:0000576	73.05	gold quality
islet of Langerhans	UBERON:0000006	71.16	gold quality
amygdala	UBERON:0001876	70.43	gold quality
left adrenal gland cortex	UBERON:0035825	68.80	gold quality
left adrenal gland	UBERON:0001234	67.53	gold quality
heart left ventricle	UBERON:0002084	67.16	gold quality
transverse colon	UBERON:0001157	66.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.45	gold quality
Ammon’s horn	UBERON:0001954	65.91	gold quality
esophagus mucosa	UBERON:0002469	65.87	gold quality
right adrenal gland	UBERON:0001233	65.76	gold quality
left ovary	UBERON:0002119	65.40	gold quality
cerebellar hemisphere	UBERON:0002245	65.40	gold quality
putamen	UBERON:0001874	64.97	gold quality
omental fat pad	UBERON:0010414	64.79	gold quality
thoracic mammary gland	UBERON:0005200	64.77	gold quality
vagina	UBERON:0000996	64.08	gold quality
skin of leg	UBERON:0001511	63.97	gold quality
anterior cingulate cortex	UBERON:0009835	63.80	gold quality
nucleus accumbens	UBERON:0001882	62.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR-1197 was upregulated in non-small cell lung cancer (NSCLC) and its downregulation has tumor-suppressing effects in NSCLC, very likely through inverse regulation on downstream target gene of HOXC11. (PMID:31181445)
• Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells. (PMID:34515615)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.